Dystrophin Associated Glycoprotein 1 (DAG1)

Dystroglycan 1; 156DAG; A3a; AGRNR; DAG; Alpha-Dystroglycan; Beta-Dystroglycan

SPN	U400
HGNC	2666
MGI	101864
PubMed	12230980
RGD	621890
UniProt	Q14118
Wiki	Dystroglycan

Dystroglycan is one of the dystrophin-associated glycoproteins, which is encoded by a 5.5 kb transcript in Homo sapiens by chromosome 3. There are two exons that are separated by a large intron. The spliced exons codes for a protein product is finally cleaved into two non-covalently associated subunits, [alpha] (N-terminal) and [beta] (C-terminal).

Dystroglycan is widely distributed in non-muscle tissues as well as in muscle tissues. During epithelial morphogenesis of kidney, the dystroglycan complex is shown to act as a receptor for the basement membrane. Dystroglycan expression in Mus musculus brain and neural retina has also been reported. However, the physiological role of dystroglycan in non-muscle tissues has remained unclear

Reference

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