Hemopoietic Cell Kinase (HCK)
JTK9; Hematopoietic cell kinase; p59-HCK/p60-HCK
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU327Hu01 | Recombinant Hemopoietic Cell Kinase (HCK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU327Hu01 | Monoclonal Antibody to Hemopoietic Cell Kinase (HCK) | WB; IHC; ICC; IP. |
| PAU327Hu01 | Polyclonal Antibody to Hemopoietic Cell Kinase (HCK) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU327Hu01 | CLIA Kit for Hemopoietic Cell Kinase (HCK) | CLIA assay for Antigen Detection |
| ELU327Hu01 | ELISA Kit for Hemopoietic Cell Kinase (HCK) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU327Mu01 | Recombinant Hemopoietic Cell Kinase (HCK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU327Mu01 | Monoclonal Antibody to Hemopoietic Cell Kinase (HCK) | WB; IHC; ICC; IP. |
| PAU327Mu01 | Polyclonal Antibody to Hemopoietic Cell Kinase (HCK) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU327Mu01 | CLIA Kit for Hemopoietic Cell Kinase (HCK) | CLIA assay for Antigen Detection |
| ELU327Mu01 | ELISA Kit for Hemopoietic Cell Kinase (HCK) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU327Ra01 | Recombinant Hemopoietic Cell Kinase (HCK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU327Ra01 | Monoclonal Antibody to Hemopoietic Cell Kinase (HCK) | WB; IHC; ICC; IP. |
| PAU327Ra01 | Polyclonal Antibody to Hemopoietic Cell Kinase (HCK) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU327Ra01 | CLIA Kit for Hemopoietic Cell Kinase (HCK) | CLIA assay for Antigen Detection |
| ELU327Ra01 | ELISA Kit for Hemopoietic Cell Kinase (HCK) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU327Ca01 | Recombinant Hemopoietic Cell Kinase (HCK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU327Ca01 | Monoclonal Antibody to Hemopoietic Cell Kinase (HCK) | WB; IHC; ICC; IP. |
| PAU327Ca01 | Polyclonal Antibody to Hemopoietic Cell Kinase (HCK) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU327Ca01 | CLIA Kit for Hemopoietic Cell Kinase (HCK) | CLIA assay for Antigen Detection |
| ELU327Ca01 | ELISA Kit for Hemopoietic Cell Kinase (HCK) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU327Po01 | Recombinant Hemopoietic Cell Kinase (HCK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU327Po01 | Monoclonal Antibody to Hemopoietic Cell Kinase (HCK) | WB; IHC; ICC; IP. |
| PAU327Po01 | Polyclonal Antibody to Hemopoietic Cell Kinase (HCK) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU327Po01 | CLIA Kit for Hemopoietic Cell Kinase (HCK) | CLIA assay for Antigen Detection |
| ELU327Po01 | ELISA Kit for Hemopoietic Cell Kinase (HCK) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU327Bo01 | Recombinant Hemopoietic Cell Kinase (HCK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU327Bo01 | Monoclonal Antibody to Hemopoietic Cell Kinase (HCK) | WB; IHC; ICC; IP. |
| PAU327Bo01 | Polyclonal Antibody to Hemopoietic Cell Kinase (HCK) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU327Bo01 | CLIA Kit for Hemopoietic Cell Kinase (HCK) | CLIA assay for Antigen Detection |
| ELU327Bo01 | ELISA Kit for Hemopoietic Cell Kinase (HCK) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU327Rb01 | Recombinant Hemopoietic Cell Kinase (HCK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU327Rb01 | Monoclonal Antibody to Hemopoietic Cell Kinase (HCK) | WB; IHC; ICC; IP. |
| PAU327Rb01 | Polyclonal Antibody to Hemopoietic Cell Kinase (HCK) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU327Rb01 | CLIA Kit for Hemopoietic Cell Kinase (HCK) | CLIA assay for Antigen Detection |
| ELU327Rb01 | ELISA Kit for Hemopoietic Cell Kinase (HCK) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU327Mo01 | Recombinant Hemopoietic Cell Kinase (HCK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU327Mo01 | Monoclonal Antibody to Hemopoietic Cell Kinase (HCK) | WB; IHC; ICC; IP. |
| PAU327Mo01 | Polyclonal Antibody to Hemopoietic Cell Kinase (HCK) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU327Mo01 | CLIA Kit for Hemopoietic Cell Kinase (HCK) | CLIA assay for Antigen Detection |
| ELU327Mo01 | ELISA Kit for Hemopoietic Cell Kinase (HCK) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Identification of a human gene (HCK) that encodes a protein-tyrosine kinase and is expressed in hemopoietic cells."
Mol. Cell. Biol. 7:2267-2275(1987) [PubMed] [Europe PMC] [Abstract]
"Novel protein-tyrosine kinase gene (hck) preferentially expressed in cells of hematopoietic origin."
Mol. Cell. Biol. 7:2276-2285(1987) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and comparative analysis of human chromosome 20."
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Two isoforms of murine hck, generated by utilization of alternative translational initiation codons, exhibit different patterns of subcellular localization."
Mol. Cell. Biol. 11:4363-4370(1991) [PubMed] [Europe PMC] [Abstract]
"The genomic locus of the human hemopoietic-specific cell protein tyrosine kinase (PTK)-encoding gene (HCK) confirms conservation of exon-intron structure among human PTKs of the src family."
Gene 113:275-280(1992) [PubMed] [Europe PMC] [Abstract]
"Physical and functional association of Src-related protein tyrosine kinases with Fc gamma RII in monocytic THP-1 cells."
J. Biol. Chem. 269:8878-8884(1994) [PubMed] [Europe PMC] [Abstract]
"Physical and functional association of the high affinity immunoglobulin G receptor (Fc gamma RI) with the kinases Hck and Lyn."
J. Exp. Med. 180:1165-1170(1994) [PubMed] [Europe PMC] [Abstract]
"The Fc gamma RI receptor signals through the activation of hck and MAP kinase."
J. Immunol. 154:4039-4047(1995) [PubMed] [Europe PMC] [Abstract]
"Myristoylation and differential palmitoylation of the HCK protein-tyrosine kinases govern their attachment to membranes and association with caveolae."
Mol. Cell. Biol. 15:3507-3515(1995) [PubMed] [Europe PMC] [Abstract]
"Signal transduction of interleukin-6 involves tyrosine phosphorylation of multiple cytosolic proteins and activation of Src-family kinases Fyn, Hck, and Lyn in multiple myeloma cell lines."
Exp. Hematol. 25:1367-1377(1997) [PubMed] [Europe PMC] [Abstract]
"Hck is activated by opsonized zymosan and A23187 in distinct subcellular fractions of human granulocytes."
J. Biol. Chem. 272:102-109(1997) [PubMed] [Europe PMC] [Abstract]
"SH3-mediated Hck tyrosine kinase activation and fibroblast transformation by the Nef protein of HIV-1."
J. Biol. Chem. 272:17899-17902(1997) [PubMed] [Europe PMC] [Abstract]
"The Src family kinase Hck interacts with Bcr-Abl by a kinase-independent mechanism and phosphorylates the Grb2-binding site of Bcr."
J. Biol. Chem. 272:33260-33270(1997) [PubMed] [Europe PMC] [Abstract]
"The proto-oncogene p120(Cbl) is a downstream substrate of the Hck protein-tyrosine kinase."
Biochem. Biophys. Res. Commun. 257:129-138(1999) [PubMed] [Europe PMC] [Abstract]
"IL-2 signaling in human monocytes involves the phosphorylation and activation of p59hck."
J. Immunol. 164:4575-4585(2000) [PubMed] [Europe PMC] [Abstract]
"Reciprocal regulation of Hck activity by phosphorylation of Tyr(527) and Tyr(416). Effect of introducing a high affinity intramolecular SH2 ligand."
J. Biol. Chem. 275:2721-2726(2000) [PubMed] [Europe PMC] [Abstract]
"Regulation of tyrosine kinase activation and granule release through beta-arrestin by CXCRI."
Nat. Immunol. 1:227-233(2000) [PubMed] [Europe PMC] [Abstract]
"The tyrosine kinase Hck is an inhibitor of HIV-1 replication counteracted by the viral vif protein."
J. Biol. Chem. 276:16885-16893(2001) [PubMed] [Europe PMC] [Abstract]
"The ORF3 protein of hepatitis E virus binds to Src homology 3 domains and activates MAPK."
J. Biol. Chem. 276:42389-42400(2001) [PubMed] [Europe PMC] [Abstract]
"The Src family kinase Hck couples BCR/ABL to STAT5 activation in myeloid leukemia cells."
EMBO J. 21:5766-5774(2002) [PubMed] [Europe PMC] [Abstract]
"Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases."
J. Biol. Chem. 277:4999-5007(2002) [PubMed] [Europe PMC] [Abstract]
"p59Hck isoform induces F-actin reorganization to form protrusions of the plasma membrane in a Cdc42- and Rac-dependent manner."
J. Biol. Chem. 277:21007-21016(2002) [PubMed] [Europe PMC] [Abstract]
"Membrane-anchored Cbl suppresses Hck protein-tyrosine kinase mediated cellular transformation."
Oncogene 21:1707-1716(2002) [PubMed] [Europe PMC] [Abstract]
"Critical role for hematopoietic cell kinase (Hck)-mediated phosphorylation of Gab1 and Gab2 docking proteins in interleukin 6-induced proliferation and survival of multiple myeloma cells."
J. Biol. Chem. 279:21658-21665(2004) [PubMed] [Europe PMC] [Abstract]
"Identification of tyrosine residues on ELMO1 that are phosphorylated by the Src-family kinase Hck."
Biochemistry 44:8841-8849(2005) [PubMed] [Europe PMC] [Abstract]
"Activation of the lysosome-associated p61Hck isoform triggers the biogenesis of podosomes."
Traffic 6:682-694(2005) [PubMed] [Europe PMC] [Abstract]
"HIV-1 Nef selectively activates Src family kinases Hck, Lyn, and c-Src through direct SH3 domain interaction."
J. Biol. Chem. 281:27029-27038(2006) [PubMed] [Europe PMC] [Abstract]
"Regulation of p73 by Hck through kinase-dependent and independent mechanisms."
BMC Mol. Biol. 8:45-45(2007) [PubMed] [Europe PMC] [Abstract]
"Inhibition of IL-6-dependent growth of myeloma cells by an acidic peptide repressing the gp130-mediated activation of Src family kinases."
Oncogene 26:4987-4998(2007) [PubMed] [Europe PMC] [Abstract]
"Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening."
BMC Immunol. 10:53-53(2009) [PubMed] [Europe PMC] [Abstract]
"The oncogenic activity of the Src family kinase Hck requires the cooperative action of the plasma membrane- and lysosome-associated isoforms."
Eur. J. Cancer 45:321-327(2009) [PubMed] [Europe PMC] [Abstract]
"Alternative splicing of ADAM15 regulates its interactions with cellular SH3 proteins."
J. Cell. Biochem. 108:877-885(2009) [PubMed] [Europe PMC] [Abstract]
"Large-scale proteomics analysis of the human kinome."
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
"c-Abl and Src-family kinases cross-talk in regulation of myeloid cell migration."
FEBS Lett. 584:15-21(2010) [PubMed] [Europe PMC] [Abstract]
"Expression of a Src family kinase in chronic myelogenous leukemia cells induces resistance to imatinib in a kinase-dependent manner."
J. Biol. Chem. 285:21446-21457(2010) [PubMed] [Europe PMC] [Abstract]
"Hematopoietic cell kinase (Hck) isoforms and phagocyte duties - from signaling and actin reorganization to migration and phagocytosis."
Eur. J. Cell Biol. 87:527-542(2008) [PubMed] [Europe PMC] [Abstract]
"Protein tyrosine kinases in neutrophil activation and recruitment."
Arch. Biochem. Biophys. 510:112-119(2011) [PubMed] [Europe PMC] [Abstract]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
"Molecular characterization of WDCP, a novel fusion partner for the anaplastic lymphoma tyrosine kinase ALK."
Biomed. Rep. 3:9-13(2015) [PubMed] [Europe PMC] [Abstract]
"Sequential assignment and secondary structure determination for the Src homology 2 domain of hematopoietic cellular kinase."
FEBS Lett. 406:131-135(1997) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of the Src family tyrosine kinase Hck."
Nature 385:602-609(1997) [PubMed] [Europe PMC] [Abstract]
"RT loop flexibility enhances the specificity of Src family SH3 domains for HIV-1 Nef."
Biochemistry 37:14683-14691(1998) [PubMed] [Europe PMC] [Abstract]
"Solution structure of the human Hck SH3 domain and identification of its ligand binding site."
J. Mol. Biol. 278:253-265(1998) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor."
Mol. Cell 3:639-648(1999) [PubMed] [Europe PMC] [Abstract]
"Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection."
Bioorg. Med. Chem. Lett. 16:118-122(2006) [PubMed] [Europe PMC] [Abstract]
"The development of 2-benzimidazole substituted pyrimidine based inhibitors of lymphocyte specific kinase (Lck)."
Bioorg. Med. Chem. Lett. 16:5973-5977(2006) [PubMed] [Europe PMC] [Abstract]
"Solution structure of a Hck SH3 domain ligand complex reveals novel interaction modes."
J. Mol. Biol. 365:1517-1532(2007) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of the Src family kinase Hck SH3-SH2 linker regulatory region supports an SH3-dominant activation mechanism."
J. Biol. Chem. 285:35455-35461(2010) [PubMed] [Europe PMC] [Abstract]
"Molecular design, functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor Nef."
PLoS ONE 6:E20033-E20033(2011) [PubMed] [Europe PMC] [Abstract]
"Conformation of the dileucine-based sorting motif in HIV-1 Nef revealed by intermolecular domain assembly."
Traffic 12:867-877(2011) [PubMed] [Europe PMC] [Abstract]
"Patterns of somatic mutation in human cancer genomes."
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]