Kisspeptin 1 (KISS1)

Metastin; KiSS-1 Metastasis-Suppressor

SPN	U290
HGNC	6341
MGI	2663985
PubMed	16932310
RGD	727850
UniProt	Q15726
Wiki	Kisspeptin

Kisspeptin is a G-protein coupled receptor ligand for GPR54. Kiss1 was originally identified as a human metastasis suppressor gene that has the ability to suppress melanoma and breast cancer metastasis. It is recently become clear that kisspeptin-GPR54 signaling has an important role in initiating GnRH secretion at puberty, the extent of which is an area of ongoing research.Kisspeptin is a metastasis suppressor of melanomas and breast cancers without affecting tumorigenicity. The encoded protein may function to inhibit chemotaxis and invasion, attenuating metastasis in malignant melanomas. Studies suggest a putative role in the regulation of events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. A polymorphism in the terminal exon of this mRNA results in two protein isoforms.

Reference

"KiSS-1, a novel human malignant melanoma metastasis-suppressor gene."
J. Natl. Cancer Inst. 88:1731-1737(1996) [PubMed] [Europe PMC] [Abstract]

Erratum
J. Natl. Cancer Inst. 89:1549-1549(1997)

"Chromosome localization and genomic structure of the KiSS-1 metastasis suppressor gene (KISS1)."
Genomics 54:145-148(1998) [PubMed] [Europe PMC] [Abstract]

"Large-scale cDNA transfection screening for genes related to cancer development and progression."
Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor."
Nature 411:613-617(2001) [PubMed] [Europe PMC] [Abstract]

"Suppression of metastasis in human breast carcinoma MDA-MB-435 cells after transfection with the metastasis suppressor gene, KiSS-1."
Cancer Res. 57:2384-2387(1997) [PubMed] [Europe PMC] [Abstract]

"Identification of highly expressed genes in metastasis-suppressed chromosome 6/human malignant melanoma hybrid cells using subtractive hybridization and differential display."
Int. J. Cancer 71:1035-1044(1997) [PubMed] [Europe PMC] [Abstract]

"The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54."
J. Biol. Chem. 276:34631-34636(2001) [PubMed] [Europe PMC] [Abstract]

"Metastin suppresses the motility and growth of CHO cells transfected with its receptor."
Biochem. Biophys. Res. Commun. 286:958-963(2001) [PubMed] [Europe PMC] [Abstract]

"KiSS-1 represses 92-kDa type IV collagenase expression by down-regulating NF-kappa B binding to the promoter as a consequence of IkappaBalpha-induced block of p65/p50 nuclear translocation."
J. Biol. Chem. 276:1164-1172(2001) [PubMed] [Europe PMC] [Abstract]

"Loss of expression of the metastasis suppressor gene KiSS1 during melanoma progression and its association with LOH of chromosome 6q16.3-q23."
Cancer Res. 61:7422-7425(2001) [PubMed] [Europe PMC] [Abstract]

"Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cells."
J. Clin. Endocrinol. Metab. 87:5336-5339(2002) [PubMed] [Europe PMC] [Abstract]

"Metastin receptor is overexpressed in papillary thyroid cancer and activates MAP kinase in thyroid cancer cells."
J. Clin. Endocrinol. Metab. 87:2399-2399(2002) [PubMed] [Europe PMC] [Abstract]

"Tumor suppressor role of KiSS-1 in bladder cancer: loss of KiSS-1 expression is associated with bladder cancer progression and clinical outcome."
Am. J. Pathol. 162:609-617(2003) [PubMed] [Europe PMC] [Abstract]

"Dramatic elevation of plasma metastin concentrations in human pregnancy: metastin as a novel placenta-derived hormone in humans."
J. Clin. Endocrinol. Metab. 88:914-919(2003) [PubMed] [Europe PMC] [Abstract]

"Cleavage of metastasis suppressor gene product KiSS-1 protein/metastin by matrix metalloproteinases."
Oncogene 22:4617-4626(2003) [PubMed] [Europe PMC] [Abstract]

"Quantitative reverse transcriptase polymerase chain reaction analysis for KiSS-1 and orphan G-protein-coupled receptor (hOT7T175) gene expression in hepatocellular carcinoma."
J. Cancer Res. Clin. Oncol. 129:531-535(2003) [PubMed] [Europe PMC] [Abstract]

"Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."
Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]

"Clinical significance of the loss of KiSS-1 and orphan G-protein-coupled receptor (hOT7T175) gene expression in esophageal squamous cell carcinoma."
Clin. Cancer Res. 10:1379-1383(2004) [PubMed] [Europe PMC] [Abstract]

"Kisspeptin-10, a KiSS-1/metastin-derived decapeptide, is a physiological invasion inhibitor of primary human trophoblasts."
J. Cell Sci. 117:1319-1328(2004) [PubMed] [Europe PMC] [Abstract]

"Downregulation of KiSS-1 expression is responsible for tumor invasion and worse prognosis in gastric carcinoma."
Int. J. Cancer 111:868-872(2004) [PubMed] [Europe PMC] [Abstract]

"Peripheral administration of metastin induces marked gonadotropin release and ovulation in the rat."
Biochem. Biophys. Res. Commun. 320:383-388(2004) [PubMed] [Europe PMC] [Abstract]

"Central and peripheral administration of kisspeptin-10 stimulates the hypothalamic-pituitary-gonadal axis."
J. Neuroendocrinol. 16:850-858(2004) [PubMed] [Europe PMC] [Abstract]

"Activation of GPR54 promotes cell cycle arrest and apoptosis of human tumor cells through a specific transcriptional program not shared by other G(q)-coupled receptors."
Biochem. Biophys. Res. Commun. 326:677-686(2005) [PubMed] [Europe PMC] [Abstract]

"Two novel missense mutations in G protein-coupled receptor 54 in a patient with hypogonadotropic hypogonadism."
J. Clin. Endocrinol. Metab. 90:1849-1855(2005) [PubMed] [Europe PMC] [Abstract]

"Inactivating KISS1 mutation and hypogonadotropic hypogonadism."
N. Engl. J. Med. 366:629-635(2012) [PubMed] [Europe PMC] [Abstract]