Tumor Necrosis Factor Alpha Induced Protein 3 (TNFaIP3)

A20; OTUD7C; TNFA1P2; OTU domain-containing protein 7C; Putative DNA-binding protein A20; Zinc finger protein A20

SPN	U061
HGNC	11896
MGI	1196377
PubMed	19165918
UniProt	P21580
Wiki	TNFAIP3

Tumor necrosis factor, alpha-induced protein 3 is a zinc finger protein, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. Knockout studies of a similar gene in mice suggested that this gene is critical for limiting inflammation by terminating TNF-induced NF-kappa B responses.

Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteosomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B.

Reference

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Submitted (OCT-2007) to the PDB data bank

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