Tumor Protein P63 (TP63)

P63; TP73L; CUSP; EEC3; KET; LMS; OFC8; RHS; SHFM4; TP53CP; Tumor Protein p53-Competing Protein; Chronic ulcerative stomatitis protein; Keratinocyte transcription factor

SPN	U052
HGNC	15979
MGI	1330810
PubMed	15324320
RGD	620863
UniProt	Q9H3D4
Wiki	TP63

TP63 also known as the p63 gene was discovered 20 years after the the discovery of the p53 tumor suppressor gene and along with p73 constitutes the p53 gene family based on their structural similarity.Tumor protein p63 is a member of the p53 family of transcription factors. p63 mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium.p63 immunostaining has utility for differentiating prostatic adenocarcinoma (the most common type of prostate cancer) and benign prostatic tissue; normal prostatic glands stain with p63 (as they have basal cells), while the malignant glands in prostatic adenocarcinoma (which lacks these cells) do not.

Reference

"A second p53-related protein, p73L, with high homology to p73."
Biochem. Biophys. Res. Commun. 248:603-607(1998) [PubMed] [Europe PMC] [Abstract]

"Cloning and chromosomal mapping of the human p53-related KET gene to chromosome 3q27 and its murine homolog Ket to mouse chromosome 16."
Mamm. Genome 9:899-902(1998) [PubMed] [Europe PMC] [Abstract]

"p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities."
Mol. Cell 2:305-316(1998) [PubMed] [Europe PMC] [Abstract]

"Cloning and functional analysis of human p51, which structurally and functionally resembles p53."
Nat. Med. 4:839-843(1998) [PubMed] [Europe PMC] [Abstract]

"Mutational analysis of the p63/p73L/p51/p40/CUSP/KET gene in human cancer cell lines using intronic primers."
Cancer Res. 59:4165-4169(1999) [PubMed] [Europe PMC] [Abstract]

"Characterization of an autoantigen associated with chronic ulcerative stomatitis: the CUSP autoantigen is a member of the p53 family."
J. Invest. Dermatol. 113:146-151(1999) [PubMed] [Europe PMC] [Abstract]

"Mutation and expression of the p51 gene in human lung cancer."
Neoplasia 1:71-79(1999) [PubMed] [Europe PMC] [Abstract]

"Transcriptional dysregulation of the p73L/p63/p51/p40/KET gene in human squamous cell carcinomas: expression of Delta Np73L, a novel dominant-negative isoform, and loss of expression of the potential tumour suppressor p51."
Br. J. Cancer 84:1235-1241(2001) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"A new human p53 homologue."
Nat. Med. 4:747-748(1998) [PubMed] [Europe PMC] [Abstract]

"High thermostability and lack of cooperative DNA binding distinguish the p63 core domain from the homologous tumor suppressor p53."
J. Biol. Chem. 276:37390-37401(2001) [PubMed] [Europe PMC] [Abstract]

"p73 and p63 are homotetramers capable of weak heterotypic interactions with each other but not with p53."
J. Biol. Chem. 274:18709-18714(1999) [PubMed] [Europe PMC] [Abstract]

"p63 identifies keratinocyte stem cells."
Proc. Natl. Acad. Sci. U.S.A. 98:3156-3161(2001) [PubMed] [Europe PMC] [Abstract]

"The p53 family member genes are involved in the Notch signal pathway."
J. Biol. Chem. 277:719-724(2002) [PubMed] [Europe PMC] [Abstract]

"Identification and characterization of HIPK2 interacting with p73 and modulating functions of the p53 family in vivo."
J. Biol. Chem. 277:32020-32028(2002) [PubMed] [Europe PMC] [Abstract]

"A C-terminal inhibitory domain controls the activity of p63 by an intramolecular mechanism."
Mol. Cell. Biol. 22:8601-8611(2002) [PubMed] [Europe PMC] [Abstract]

"Complex transcriptional effects of p63 isoforms: identification of novel activation and repression domains."
Mol. Cell. Biol. 22:8659-8668(2002) [PubMed] [Europe PMC] [Abstract]

"SSRP1 functions as a co-activator of the transcriptional activator p63."
EMBO J. 21:5487-5497(2002) [PubMed] [Europe PMC] [Abstract]

Erratum
EMBO J. 23:1679-1679(2004)

"WW domain-containing E3 ubiquitin protein ligase 1 targets p63 transcription factor for ubiquitin-mediated proteasomal degradation and regulates apoptosis."
Cell Death Differ. 15:1941-1951(2008) [PubMed] [Europe PMC] [Abstract]

"SCC-112 gene is involved in tumor progression and promotes the cell proliferation in G2/M phase."
J. Cancer Res. Clin. Oncol. 134:453-462(2008) [PubMed] [Europe PMC] [Abstract]

"NIR, an inhibitor of histone acetyltransferases, regulates transcription factor TAp63 and is controlled by the cell cycle."
Nucleic Acids Res. 38:3159-3171(2010) [PubMed] [Europe PMC] [Abstract]

"Exome sequence identifies RIPK4 as the Bartsocas-Papas syndrome locus."
Am. J. Hum. Genet. 90:69-75(2012) [PubMed] [Europe PMC] [Abstract]

"Solution structure of the C-terminal domain of p63."
Submitted (NOV-2004) to the PDB data bank

"Heterozygous germline mutations in the p53 homolog p63 are the cause of EEC syndrome."
Cell 99:143-153(1999) [PubMed] [Europe PMC] [Abstract]

"Split-hand/split-foot malformation is caused by mutations in the p63 gene on 3q27."
Am. J. Hum. Genet. 67:59-66(2000) [PubMed] [Europe PMC] [Abstract]

"TP63 gene mutation in ADULT syndrome."
Eur. J. Hum. Genet. 9:642-645(2001) [PubMed] [Europe PMC] [Abstract]

"Hay-Wells syndrome is caused by heterozygous missense mutations in the SAM domain of p63."
Hum. Mol. Genet. 10:221-229(2001) [PubMed] [Europe PMC] [Abstract]

"p63 gene mutations in EEC syndrome, limb-mammary syndrome, and isolated split hand-split foot malformation suggest a genotype-phenotype correlation."
Am. J. Hum. Genet. 69:481-492(2001) [PubMed] [Europe PMC] [Abstract]

"Gain-of-function mutation in ADULT syndrome reveals the presence of a second transactivation domain in p63."
Hum. Mol. Genet. 11:799-804(2002) [PubMed] [Europe PMC] [Abstract]

"EEC syndrome type 3 with a heterozygous germline mutation in the P63 gene and B cell lymphoma."
Am. J. Med. Genet. A 120:370-373(2003) [PubMed] [Europe PMC] [Abstract]

"The Rapp-Hodgkin syndrome results from mutations of the TP63 gene."
Eur. J. Hum. Genet. 11:700-704(2003) [PubMed] [Europe PMC] [Abstract]

"Heterozygous mutation in the SAM domain of p63 underlies Rapp-Hodgkin ectodermal dysplasia."
J. Dent. Res. 82:433-437(2003) [PubMed] [Europe PMC] [Abstract]

"Molecular evidence that AEC syndrome and Rapp-Hodgkin syndrome are variable expression of a single genetic disorder."
Clin. Genet. 66:79-80(2004) [PubMed] [Europe PMC] [Abstract]

"A mutation of the p63 gene in non-syndromic cleft lip."
J. Med. Genet. 43:E28-E28(2006) [PubMed] [Europe PMC] [Abstract]