FK506 Binding Protein 12 Rapamycin Associated Protein (FRAP)

FRAP1; MTOR; FRAP2; MTOR; RAFT1; RAPT1; Mammalian Target Of Rapamycin; FKBP12-Rapamycin Complex-Associated Protein 1; Rapamycin and FKBP12 target 1

SPN	T935
HGNC	3942
MGI	1928394
PubMed	11146621
RGD	68371
UniProt	P42345
Wiki	FRAP

The mammalian target of rapamycin (mTOR) also known as FK506 binding protein 12-rapamycin associated protein 1 (FRAP1) is a protein which in humans is encoded by the FRAP1 gene.mTOR is a serine/threonine protein kinase that regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis, and transcription.

Current research indicates that mTOR integrates the input from multiple upstream pathways, including insulin, growth factors (such as IGF-1 and IGF-2), and mitogens.mTOR also functions as a sensor of cellular nutrient and energy levels and redox status.The disregulation of the mTOR pathway is implicated as a contributing factor to various human disease processes, especially various types of cancer.

Reference

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