Casein Kinase 1 Alpha 1 (CSNK1a1)

CSNK1-A1; CK1; HLCDGP1

SPN	T928
HGNC	2451
MGI	1934950
PubMed	24616378
RGD	71098
UniProt	P48729
Wiki	CSNK1A1

Casein kinase activity was found to be present in most cell types and to be associated with multiple enzymes. The type 1 casein kinase family of related gene products are now given designations such as "casein kinase 1 alpha" and "casein kinase 1 epsilon". Casein kinase 1 alpha has been suggested to play a role in phosphorylation of Disheveled in the Wnt signaling pathway .Jia et al. (2004) showed that protein kinase A (PKA) and casein kinase I (CKI) regulate Smo cell surface accumulation and activity in response to hedgehog (Hh). Blocking PKA or CKI activity in the Drosophila wing disc prevented Hh-induced Smo accumulation and attenuated pathway activity, whereas increasing PKA activity promoted Smo accumulation and pathway activation.

Reference

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