Prostacyclin Receptor (PTGIR)
PTGI-R; IP1; PRIPR; Prostaglandin I2 Receptor; Prostanoid IP receptor
Prostacyclin receptor is a member of the G-protein coupled receptor family. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and inhibition of platelet aggregation through binding to this receptor.
When binding a prostacyclin-molecule, the receptor changes conformation and activates Gs, with its activation of cAMP and increase in protein kinase A (PKA) activity.In vasodilation, the PKA activity causes phosphorylation of MLCK, decreasing its activity, resulting in dephosphorylation of MLC of myosin. The smooth muscle relaxation leads to vasodilation.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT898Hu01 | Recombinant Prostacyclin Receptor (PTGIR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT898Hu01 | Monoclonal Antibody to Prostacyclin Receptor (PTGIR) | WB; IHC; ICC; IP. |
| PAT898Hu01 | Polyclonal Antibody to Prostacyclin Receptor (PTGIR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT898Hu01 | CLIA Kit for Prostacyclin Receptor (PTGIR) | CLIA assay for Antigen Detection |
| ELT898Hu01 | ELISA Kit for Prostacyclin Receptor (PTGIR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT898Mu01 | Recombinant Prostacyclin Receptor (PTGIR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT898Mu01 | Monoclonal Antibody to Prostacyclin Receptor (PTGIR) | WB; IHC; ICC; IP. |
| PAT898Mu01 | Polyclonal Antibody to Prostacyclin Receptor (PTGIR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT898Mu01 | CLIA Kit for Prostacyclin Receptor (PTGIR) | CLIA assay for Antigen Detection |
| ELT898Mu01 | ELISA Kit for Prostacyclin Receptor (PTGIR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT898Ra01 | Recombinant Prostacyclin Receptor (PTGIR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT898Ra01 | Monoclonal Antibody to Prostacyclin Receptor (PTGIR) | WB; IHC; ICC; IP. |
| PAT898Ra01 | Polyclonal Antibody to Prostacyclin Receptor (PTGIR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT898Ra01 | CLIA Kit for Prostacyclin Receptor (PTGIR) | CLIA assay for Antigen Detection |
| ELT898Ra01 | ELISA Kit for Prostacyclin Receptor (PTGIR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT898Ca01 | Recombinant Prostacyclin Receptor (PTGIR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT898Ca01 | Monoclonal Antibody to Prostacyclin Receptor (PTGIR) | WB; IHC; ICC; IP. |
| PAT898Ca01 | Polyclonal Antibody to Prostacyclin Receptor (PTGIR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT898Ca01 | CLIA Kit for Prostacyclin Receptor (PTGIR) | CLIA assay for Antigen Detection |
| ELT898Ca01 | ELISA Kit for Prostacyclin Receptor (PTGIR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT898Po01 | Recombinant Prostacyclin Receptor (PTGIR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT898Po01 | Monoclonal Antibody to Prostacyclin Receptor (PTGIR) | WB; IHC; ICC; IP. |
| PAT898Po01 | Polyclonal Antibody to Prostacyclin Receptor (PTGIR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT898Po01 | CLIA Kit for Prostacyclin Receptor (PTGIR) | CLIA assay for Antigen Detection |
| ELT898Po01 | ELISA Kit for Prostacyclin Receptor (PTGIR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT898Bo01 | Recombinant Prostacyclin Receptor (PTGIR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT898Bo01 | Monoclonal Antibody to Prostacyclin Receptor (PTGIR) | WB; IHC; ICC; IP. |
| PAT898Bo01 | Polyclonal Antibody to Prostacyclin Receptor (PTGIR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT898Bo01 | CLIA Kit for Prostacyclin Receptor (PTGIR) | CLIA assay for Antigen Detection |
| ELT898Bo01 | ELISA Kit for Prostacyclin Receptor (PTGIR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT898Rb01 | Recombinant Prostacyclin Receptor (PTGIR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT898Rb01 | Monoclonal Antibody to Prostacyclin Receptor (PTGIR) | WB; IHC; ICC; IP. |
| PAT898Rb01 | Polyclonal Antibody to Prostacyclin Receptor (PTGIR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT898Rb01 | CLIA Kit for Prostacyclin Receptor (PTGIR) | CLIA assay for Antigen Detection |
| ELT898Rb01 | ELISA Kit for Prostacyclin Receptor (PTGIR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT898Mo01 | Recombinant Prostacyclin Receptor (PTGIR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT898Mo01 | Monoclonal Antibody to Prostacyclin Receptor (PTGIR) | WB; IHC; ICC; IP. |
| PAT898Mo01 | Polyclonal Antibody to Prostacyclin Receptor (PTGIR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT898Mo01 | CLIA Kit for Prostacyclin Receptor (PTGIR) | CLIA assay for Antigen Detection |
| ELT898Mo01 | ELISA Kit for Prostacyclin Receptor (PTGIR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Cloning and expression of a cDNA for the human prostanoid IP receptor."
J. Biol. Chem. 269:12173-12178(1994) [PubMed] [Europe PMC] [Abstract]
"Cloning and expression of a cDNA for the human prostacyclin receptor."
FEBS Lett. 344:74-78(1994) [PubMed] [Europe PMC] [Abstract]
"Molecular cloning of human prostacyclin receptor cDNA and its gene expression in the cardiovascular system."
Circulation 90:1643-1647(1994) [PubMed] [Europe PMC] [Abstract]
"Structural organization and chromosomal assignment of the human prostacyclin receptor gene."
Genomics 27:142-148(1995) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Investigation of a functional requirement for isoprenylation by the human prostacyclin receptor."
Eur. J. Biochem. 269:1714-1725(2002) [PubMed] [Europe PMC] [Abstract]
"Palmitoylation of the human prostacyclin receptor. Functional implications of palmitoylation and isoprenylation."
J. Biol. Chem. 278:6947-6958(2003) [PubMed] [Europe PMC] [Abstract]
"Role of extracellular cysteine residues in dimerization/oligomerization of the human prostacyclin receptor."
Eur. J. Pharmacol. 494:11-22(2004) [PubMed] [Europe PMC] [Abstract]