Follicle Stimulating Hormone Receptor (FSHR)

FSHRO; LGR1; ODG1; FSH-Receptor; Follitropin receptor

SPN	T882
HGNC	3969
MGI	95583
PubMed	19017414
RGD	2632
UniProt	P23945
Wiki	FSH-receptor

The follicle stimulating hormone receptor is a transmembrane receptor that interacts with the follicle stimulating hormone (FSH) and represents a G protein-coupled receptor (GPCR). Its activation is necessary for the hormonal functioning of FSH. FSHRs are found in the ovary, testis, and uterus.The FSHR consists of 695 amino acids and has a molecular mass of about 76 kDa. Like other GPCRs, the FSH-receptor possess seven membrane-spanning domains or transmembrane helices.Upon binding FSH externally to the membrane, a transduction of the signal takes place that activates the G protein that is bound to the receptor internally. With FSH attached, the receptor shifts conformation and thus mechanically activates the G protein, which detaches from the receptor and activates the cAMP system.

Reference

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"The cloning of the human follicle stimulating hormone receptor and its expression in COS-7, CHO, and Y-1 cells."
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Mol. Cell. Endocrinol. 102:93-102(1994) [PubMed] [Europe PMC] [Abstract]

"Localization of the human FSH receptor to chromosome 2p21 using a genomic probe comprising exon 10."
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Nature 433:269-277(2005) [PubMed] [Europe PMC] [Abstract]

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Cell 82:959-968(1995) [PubMed] [Europe PMC] [Abstract]

"A mutation in the follicle-stimulating hormone receptor occurs frequently in human ovarian sex cord tumors."
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"An activating mutation of the follicle-stimulating hormone receptor autonomously sustains spermatogenesis in a hypophysectomized man."
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"The frequency of an inactivating point mutation (566C-->T) of the human follicle-stimulating hormone receptor gene in four populations using allele-specific hybridization and time-resolved fluorometry."
J. Clin. Endocrinol. Metab. 83:4338-4343(1998) [PubMed] [Europe PMC] [Abstract]

"A novel phenotype related to partial loss of function mutations of the follicle stimulating hormone receptor."
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Erratum
Nat. Genet. 23:373-373(1999)

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"A chorionic gonadotropin-sensitive mutation in the follicle-stimulating hormone receptor as a cause of familial gestational spontaneous ovarian hyperstimulation syndrome."
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"Presence and absence of follicle-stimulating hormone receptor mutations provide some insights into spontaneous ovarian hyperstimulation syndrome physiopathology."
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"Identification of the first germline mutation in the extracellular domain of the follitropin receptor responsible for spontaneous ovarian hyperstimulation syndrome."
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