Crystallin Alpha B (CRYaB)

CRY-AB; CRYA-B; CRYA2; CTPP2; HSPB5; Heat shock protein beta-5; Renal carcinoma antigen NY-REN-27; Rosenthal fiber component

SPN	T878
HGNC	2389
MGI	88516
PubMed	22158051
RGD	2414
UniProt	P02511
Wiki	CRYAB

Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens.

These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy.

Reference

"The primary structure of the B2 chain of human alpha-crystallin."
FEBS Lett. 74:82-84(1977) [PubMed] [Europe PMC] [Abstract]

"Human alpha B-crystallin gene and preferential promoter function in lens."
Genomics 7:594-601(1990) [PubMed] [Europe PMC] [Abstract]

"Accumulation of alpha B-crystallin in brains of patients with Alexander's disease is not due to an abnormality of the 5'-flanking and coding sequence of the genomic DNA."
Neurosci. Lett. 140:89-92(1992) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Copurification of small heat shock protein with alpha B crystallin from human skeletal muscle."
J. Biol. Chem. 267:7718-7725(1992) [PubMed] [Europe PMC] [Abstract]

"Sequence analysis of betaA3, betaB3, and betaA4 crystallins completes the identification of the major proteins in young human lens."
J. Biol. Chem. 272:2268-2275(1997) [PubMed] [Europe PMC] [Abstract]

"The major protein expression profile and two-dimensional protein database of human heart."
Electrophoresis 16:1160-1169(1995) [PubMed] [Europe PMC] [Abstract]

"Alpha B-crystallin is expressed in non-lenticular tissues and accumulates in Alexander's disease brain."
Cell 57:71-78(1989) [PubMed] [Europe PMC] [Abstract]

"Simultaneous racemization and isomerization at specific aspartic acid residues in alpha B-crystallin from the aged human lens."
Biochim. Biophys. Acta 1204:157-163(1994) [PubMed] [Europe PMC] [Abstract]

"Post-translational modifications of water-soluble human lens crystallins from young adults."
J. Biol. Chem. 269:12494-12502(1994) [PubMed] [Europe PMC] [Abstract]

"Antigens recognized by autologous antibody in patients with renal-cell carcinoma."
Int. J. Cancer 83:456-464(1999) [PubMed] [Europe PMC] [Abstract]

"The major in vivo modifications of the human water-insoluble lens crystallins are disulfide bonds, deamidation, methionine oxidation and backbone cleavage."
Exp. Eye Res. 71:195-207(2000) [PubMed] [Europe PMC] [Abstract]

"Identification and characterization of a novel protein from Sertoli cells, PASS1, that associates with mammalian small stress protein hsp27."
J. Biol. Chem. 275:18724-18731(2000) [PubMed] [Europe PMC] [Abstract]

"Alpha-B crystallin gene (CRYAB) mutation causes dominant congenital posterior polar cataract in humans."
Am. J. Hum. Genet. 69:1141-1145(2001) [PubMed] [Europe PMC] [Abstract]

"Ser-59 is the major phosphorylation site in alphaB-crystallin accumulated in the brains of patients with Alexander's disease."
J. Neurochem. 76:730-736(2001) [PubMed] [Europe PMC] [Abstract]

"In vivo carbamylation and acetylation of water-soluble human lens alphaB-crystallin lysine 92."
Protein Sci. 10:1130-1136(2001) [PubMed] [Europe PMC] [Abstract]

"Myofibrillar myopathy caused by novel dominant negative alpha B-crystallin mutations."
Ann. Neurol. 54:804-810(2003) [PubMed] [Europe PMC] [Abstract]

"Association of the chaperone alphaB-crystallin with titin in heart muscle."
J. Biol. Chem. 279:7917-7924(2004) [PubMed] [Europe PMC] [Abstract]

"HSPB7 is a SC35 speckle resident small heat shock protein."
Biochim. Biophys. Acta 1793:1343-1353(2009) [PubMed] [Europe PMC] [Abstract]

"Importance of eye lens alpha-crystallin heteropolymer with 3:1 alphaA to alphaB ratio: stability, aggregation, and modifications."
IUBMB Life 62:693-702(2010) [PubMed] [Europe PMC] [Abstract]

"Infantile muscular dystrophy in Canadian aboriginals is an alphaB-crystallinopathy."
Ann. Neurol. 69:866-871(2011) [PubMed] [Europe PMC] [Abstract]

"Acetylation of alphaA-crystallin in the human lens: effects on structure and chaperone function."
Biochim. Biophys. Acta 1822:120-129(2012) [PubMed] [Europe PMC] [Abstract]

"Identification of histidine residues involved in Zn(2+) binding to alphaA- and alphaB-Crystallin by chemical modification and MALDI TOF mass spectrometry."
Protein J. 31:623-640(2012) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"A missense mutation in the alphaB-crystallin chaperone gene causes a desmin-related myopathy."
Nat. Genet. 20:92-95(1998) [PubMed] [Europe PMC] [Abstract]

"Alteration of protein-protein interactions of congenital cataract crystallin mutants."
Invest. Ophthalmol. Vis. Sci. 44:1155-1159(2003) [PubMed] [Europe PMC] [Abstract]

"Crystal structures of alpha-crystallin domain dimers of alphaB-crystallin and Hsp20."
J. Mol. Biol. 392:1242-1252(2009) [PubMed] [Europe PMC] [Abstract]

"Alpha B-crystallin mutation in dilated cardiomyopathy."
Biochem. Biophys. Res. Commun. 342:379-386(2006) [PubMed] [Europe PMC] [Abstract]

"alphaB-crystallin mutation in dilated cardiomyopathies: low prevalence in a consecutive series of 200 unrelated probands."
Biochem. Biophys. Res. Commun. 346:1115-1117(2006) [PubMed] [Europe PMC] [Abstract]

"A novel CRYAB mutation resulting in multisystemic disease."
Neuromuscul. Disord. 22:66-72(2012) [PubMed] [Europe PMC] [Abstract]