Gamma-Aminobutyric Acid A Receptor Alpha 1 (gABRa1)
EJM5; GABRA1; GABAAR1; GABA-AR1
The receptor is an ionotropic receptor and ligand-gated ion channel. Its endogenous ligand is γ-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the central nervous system. Upon activation, the GABAA receptor selectively conducts Cl- through its pore, resulting in hyperpolarization of the neuron. This causes an inhibitory effect on neurotransmission by diminishing the chance of a successful action potential occurring.
The active site of the GABAA receptor is the binding site for GABA and several drugs such as muscimol, gaboxadol, and bicuculline. The protein also contains a number of different allosteric binding sites which modulate the activity of the receptor indirectly.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT700Hu01 | Recombinant Gamma-Aminobutyric Acid A Receptor Alpha 1 (gABRa1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT700Hu01 | Monoclonal Antibody to Gamma-Aminobutyric Acid A Receptor Alpha 1 (gABRa1) | WB; IHC; ICC; IP. |
| PAT700Hu01 | Polyclonal Antibody to Gamma-Aminobutyric Acid A Receptor Alpha 1 (gABRa1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT700Hu01 | CLIA Kit for Gamma-Aminobutyric Acid A Receptor Alpha 1 (gABRa1) | CLIA assay for Antigen Detection |
| ELT700Hu01 | ELISA Kit for Gamma-Aminobutyric Acid A Receptor Alpha 1 (gABRa1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT700Mu01 | Recombinant Gamma-Aminobutyric Acid A Receptor Alpha 1 (gABRa1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT700Mu01 | Monoclonal Antibody to Gamma-Aminobutyric Acid A Receptor Alpha 1 (gABRa1) | WB; IHC; ICC; IP. |
| PAT700Mu01 | Polyclonal Antibody to Gamma-Aminobutyric Acid A Receptor Alpha 1 (gABRa1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT700Mu01 | CLIA Kit for Gamma-Aminobutyric Acid A Receptor Alpha 1 (gABRa1) | CLIA assay for Antigen Detection |
| ELT700Mu01 | ELISA Kit for Gamma-Aminobutyric Acid A Receptor Alpha 1 (gABRa1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT700Ra01 | Recombinant Gamma-Aminobutyric Acid A Receptor Alpha 1 (gABRa1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT700Ra01 | Monoclonal Antibody to Gamma-Aminobutyric Acid A Receptor Alpha 1 (gABRa1) | WB; IHC; ICC; IP. |
| PAT700Ra01 | Polyclonal Antibody to Gamma-Aminobutyric Acid A Receptor Alpha 1 (gABRa1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT700Ra01 | CLIA Kit for Gamma-Aminobutyric Acid A Receptor Alpha 1 (gABRa1) | CLIA assay for Antigen Detection |
| ELT700Ra01 | ELISA Kit for Gamma-Aminobutyric Acid A Receptor Alpha 1 (gABRa1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT700Ca01 | Recombinant Gamma-Aminobutyric Acid A Receptor Alpha 1 (gABRa1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT700Ca01 | Monoclonal Antibody to Gamma-Aminobutyric Acid A Receptor Alpha 1 (gABRa1) | WB; IHC; ICC; IP. |
| PAT700Ca01 | Polyclonal Antibody to Gamma-Aminobutyric Acid A Receptor Alpha 1 (gABRa1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT700Ca01 | CLIA Kit for Gamma-Aminobutyric Acid A Receptor Alpha 1 (gABRa1) | CLIA assay for Antigen Detection |
| ELT700Ca01 | ELISA Kit for Gamma-Aminobutyric Acid A Receptor Alpha 1 (gABRa1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT700Po01 | Recombinant Gamma-Aminobutyric Acid A Receptor Alpha 1 (gABRa1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT700Po01 | Monoclonal Antibody to Gamma-Aminobutyric Acid A Receptor Alpha 1 (gABRa1) | WB; IHC; ICC; IP. |
| PAT700Po01 | Polyclonal Antibody to Gamma-Aminobutyric Acid A Receptor Alpha 1 (gABRa1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT700Po01 | CLIA Kit for Gamma-Aminobutyric Acid A Receptor Alpha 1 (gABRa1) | CLIA assay for Antigen Detection |
| ELT700Po01 | ELISA Kit for Gamma-Aminobutyric Acid A Receptor Alpha 1 (gABRa1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT700Bo01 | Recombinant Gamma-Aminobutyric Acid A Receptor Alpha 1 (gABRa1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT700Bo01 | Monoclonal Antibody to Gamma-Aminobutyric Acid A Receptor Alpha 1 (gABRa1) | WB; IHC; ICC; IP. |
| PAT700Bo01 | Polyclonal Antibody to Gamma-Aminobutyric Acid A Receptor Alpha 1 (gABRa1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT700Bo01 | CLIA Kit for Gamma-Aminobutyric Acid A Receptor Alpha 1 (gABRa1) | CLIA assay for Antigen Detection |
| ELT700Bo01 | ELISA Kit for Gamma-Aminobutyric Acid A Receptor Alpha 1 (gABRa1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT700Rb01 | Recombinant Gamma-Aminobutyric Acid A Receptor Alpha 1 (gABRa1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT700Rb01 | Monoclonal Antibody to Gamma-Aminobutyric Acid A Receptor Alpha 1 (gABRa1) | WB; IHC; ICC; IP. |
| PAT700Rb01 | Polyclonal Antibody to Gamma-Aminobutyric Acid A Receptor Alpha 1 (gABRa1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT700Rb01 | CLIA Kit for Gamma-Aminobutyric Acid A Receptor Alpha 1 (gABRa1) | CLIA assay for Antigen Detection |
| ELT700Rb01 | ELISA Kit for Gamma-Aminobutyric Acid A Receptor Alpha 1 (gABRa1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT700Mo01 | Recombinant Gamma-Aminobutyric Acid A Receptor Alpha 1 (gABRa1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT700Mo01 | Monoclonal Antibody to Gamma-Aminobutyric Acid A Receptor Alpha 1 (gABRa1) | WB; IHC; ICC; IP. |
| PAT700Mo01 | Polyclonal Antibody to Gamma-Aminobutyric Acid A Receptor Alpha 1 (gABRa1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT700Mo01 | CLIA Kit for Gamma-Aminobutyric Acid A Receptor Alpha 1 (gABRa1) | CLIA assay for Antigen Detection |
| ELT700Mo01 | ELISA Kit for Gamma-Aminobutyric Acid A Receptor Alpha 1 (gABRa1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Sequence and expression of human GABAA receptor alpha 1 and beta 1 subunits."
FEBS Lett. 244:361-364(1989) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Isolation of a cDNA clone for the alpha subunit of the human GABA-A receptor."
Biochem. Biophys. Res. Commun. 156:1039-1045(1988) [PubMed] [Europe PMC] [Abstract]
"Novel alpha1 and gamma2 GABAA receptor subunit mutations in families with idiopathic generalized epilepsy."
Eur. J. Neurosci. 34:237-249(2011) [PubMed] [Europe PMC] [Abstract]
"GABRA1 and STXBP1: novel genetic causes of Dravet syndrome."
Neurology 82:1245-1253(2014) [PubMed] [Europe PMC] [Abstract]
"Mutation of GABRA1 in an autosomal dominant form of juvenile myoclonic epilepsy."
Nat. Genet. 31:184-189(2002) [PubMed] [Europe PMC] [Abstract]
"A mutation in the GABA(A) receptor alpha(1)-subunit is associated with absence epilepsy."
Ann. Neurol. 59:983-987(2006) [PubMed] [Europe PMC] [Abstract]