Low Density Lipoprotein Receptor Related Protein Associated Protein 1 (LRPAP1)

A2MRAP; A2RAP; HBP44; MRAP; RAP; Alpha-2-Macroglobulin Receptor-Associated Protein 1

SPN	T686
HGNC	6701
MGI	96829
PubMed	14959998
RGD	620700
UniProt	P30533
Wiki	LRPAP1

LRPAP1 is involved with trafficking of certain members of the LDL receptor family including LRP1 and LRP2.The alpha-2-macroglobulin receptor complex, as purified by affinity chromatography, contains 3 polypeptides: a 515-kD heavy chain, an 85-kD light chain, and a 39-kD associated protein.The deduced amino acid sequence contains a putative signal sequence that precedes the 323-residue mature protein. The sequence showed 73% identity with a rat protein reported to be a pathogenic domain of the Heymann nephritis antigen gp330 and 77% identity to a 44-kD mouse heparin-binding protein termed HBP-44. There are also similarities between MRAP and apolipoprotein E. Studies indicated that the molecule is present on the cell surface, forming a complex with the heavy and light chains of the alpha-2-macroglobulin receptor.

Reference

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