Sjogren Syndrome Antigen B (SSB)

LARP3; Lupus La Protein; Autoantigen La; La Ribonucleoprotein Domain Family,Member 3; Autoantigen SSB/La

SPN	T583
HGNC	11316
MGI	98423
PubMed	23129761
RGD	620804
UniProt	P05455
Wiki	SSB

Sjogren syndrome antigen B (autoantigen La), also known as SSB,La is involved in diverse aspects of RNA metabolism, including binding and protecting 3-prime UUU(OH) elements of newly RNA polymerase III-transcribed RNA, processing 5-prime and 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. La protein was originally defined by its reactivity with autoantibodies from patients with Sjogren syndrome and systemic lupus erythematosus (SLE) (Teplova et al., 2006).Grolz and Bachmann (1997) stated that there are 3 La pseudogenes. They also found that alternative splicing gives rise to 3 different mRNAs, all of which were expressed in all tissues tested, and all of which were translated into nuclear La protein in transfected mouse cells.

Reference

"Ribonucleoprotein SS-B/La belongs to a protein family with consensus sequences for RNA-binding."
Nucleic Acids Res. 17:2233-2244(1989) [PubMed] [Europe PMC] [Abstract]

"Genomic structure and amino acid sequence domains of the human La autoantigen."
J. Biol. Chem. 263:18043-18051(1988) [PubMed] [Europe PMC] [Abstract]

"Human protein factory for converting the transcriptome into an in vitro-expressed proteome."
Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Characteristics and epitope mapping of a cloned human autoantigen La."
J. Immunol. 140:3212-3218(1988) [PubMed] [Europe PMC] [Abstract]

"Isolation and analysis of cDNA clones expressing human lupus La antigen."
Proc. Natl. Acad. Sci. U.S.A. 82:2115-2119(1985) [PubMed] [Europe PMC] [Abstract]

"Function of the mammalian La protein: evidence for its action in transcription termination by RNA polymerase III."
EMBO J. 8:851-861(1989) [PubMed] [Europe PMC] [Abstract]

"Phosphorylation of the human La antigen on serine 366 can regulate recycling of RNA polymerase III transcription complexes."
Cell 88:707-715(1997) [PubMed] [Europe PMC] [Abstract]

"The human La (SS-B) autoantigen interacts with DDX15/hPrp43, a putative DEAH-box RNA helicase."
RNA 8:1428-1443(2002) [PubMed] [Europe PMC] [Abstract]

"Rabip4' is an effector of rab5 and rab4 and regulates transport through early endosomes."
Mol. Biol. Cell 15:611-624(2004) [PubMed] [Europe PMC] [Abstract]

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."
Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Structure of the C-terminal domain of human La protein reveals a novel RNA recognition motif coupled to a helical nuclear retention element."
Structure 11:833-843(2003) [PubMed] [Europe PMC] [Abstract]

"Structural analysis of cooperative RNA binding by the La motif and central RRM domain of human La protein."
Nat. Struct. Mol. Biol. 11:323-329(2004) [PubMed] [Europe PMC] [Abstract]

"Structural basis for recognition and sequestration of UUU(OH) 3' termini of nascent RNA polymerase III transcripts by La, a rheumatic disease autoantigen."
Mol. Cell 21:75-85(2006) [PubMed] [Europe PMC] [Abstract]

"Structural analysis reveals conformational plasticity in the recognition of RNA 3' ends by the human La protein."
Structure 16:852-862(2008) [PubMed] [Europe PMC] [Abstract]