Protein C Inhibitor (PCI)

SERPINA5; PAI3; PLANH3; PROCI; Serpin Peptidase Inhibitor Clade A 5; Plasma Serine Protease Inhibitor; Plasminogen Activator Inhibitor 3; Acrosomal serine protease inhibitor

SPN	T388
HGNC	8723
MGI	107817
PubMed	24388360
RGD	619817
UniProt	P05154
Wiki	SERPINA5

Protein C inhibitor (PCI, SERPINA5) is a serine protease inhibitor (serpin) which limits the expression of protein C.Suzuki et al. (1987) determined the sequence of cDNA for human protein C inhibitor (PCI). A high degree of homology of the deduced amino acid sequence to that of other known inhibitors clearly demonstrated that protein C inhibitor is a member of the superfamily of serine protease inhibitors including alpha-1-antichymotrypsin (AACT), alpha-1-antitrypsin (AAT; PI), antithrombin III (AT3), and angiotensinogen (AGT). Protein C inhibitor is sometimes referred to as plasminogen activator inhibitor-3 (PAI3) because it also inhibits plasminogen activators (Meijers and Chung, 1991). Plasminogen activator inhibitor-1 (PAI1) has structural similarities to PCI.

Reference

"Characterization of a cDNA for human protein C inhibitor. A new member of the plasma serine protease inhibitor superfamily."
J. Biol. Chem. 262:611-616(1987) [PubMed] [Europe PMC] [Abstract]

"Evidence for a glycine residue at position 316 in human protein C inhibitor."
Thromb. Res. 59:389-393(1990) [PubMed] [Europe PMC] [Abstract]

"Organization of the gene coding for human protein C inhibitor (plasminogen activator inhibitor-3). Assignment of the gene to chromosome 14."
J. Biol. Chem. 266:15028-15034(1991) [PubMed] [Europe PMC] [Abstract]

"Gene organization of human protein C inhibitor, a member of SERPIN family proteins encoded in five exons."
Int. J. Hematol. 58:213-224(1993) [PubMed] [Europe PMC] [Abstract]

"A two-allele polymorphism in protein C inhibitor with varying frequencies in different ethnic populations."
Thromb. Haemost. 75:62-69(1996) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and analysis of human chromosome 14."
Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Human sperm-egg binding is inhibited by peptides corresponding to core region of an acrosomal serine protease inhibitor."
Mol. Reprod. Dev. 34:280-291(1993) [PubMed] [Europe PMC] [Abstract]

"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

"Protein C inhibitor from human plasma: characterization of native and cleaved inhibitor and demonstration of inhibitor complexes with plasma kallikrein."
Thromb. Haemost. 62:885-891(1989) [PubMed] [Europe PMC] [Abstract]

"Mechanism of inhibition of activated protein C by protein C inhibitor."
J. Biochem. 95:187-195(1984) [PubMed] [Europe PMC] [Abstract]

"Inhibition of urokinase by protein C-inhibitor (PCI). Evidence for identity of PCI and plasminogen activator inhibitor 3."
Biol. Chem. Hoppe-Seyler 368:1427-1433(1987) [PubMed] [Europe PMC] [Abstract]

"Inactivation of human plasma kallikrein and factor XIa by protein C inhibitor."
Biochemistry 27:4231-4237(1988) [PubMed] [Europe PMC] [Abstract]

"Functionally active protein C inhibitor/plasminogen activator inhibitor-3 (PCI/PAI-3) is secreted in seminal vesicles, occurs at high concentrations in human seminal plasma and complexes with prostate-specific antigen."
Thromb. Res. 64:309-320(1991) [PubMed] [Europe PMC] [Abstract]

"Protein C inhibitor in human body fluids. Seminal plasma is rich in inhibitor antigen deriving from cells throughout the male reproductive system."
J. Clin. Invest. 89:1094-1101(1992) [PubMed] [Europe PMC] [Abstract]

"Inhibition of acrosin by protein C inhibitor and localization of protein C inhibitor to spermatozoa."
Am. J. Physiol. 267:C466-C472(1994) [PubMed] [Europe PMC] [Abstract]

"Intermolecular interactions between protein C inhibitor and coagulation proteases."
Biochemistry 34:12991-12997(1995) [PubMed] [Europe PMC] [Abstract]

"Complexes of tissue kallikrein with protein C inhibitor in human semen and urine."
Eur. J. Biochem. 234:641-649(1995) [PubMed] [Europe PMC] [Abstract]

"Characterization of semenogelin II and its molecular interaction with prostate-specific antigen and protein C inhibitor."
Eur. J. Biochem. 238:88-96(1996) [PubMed] [Europe PMC] [Abstract]

"Protein C inhibitor acts as a procoagulant by inhibiting the thrombomodulin-induced activation of protein C in human plasma."
Blood 91:1542-1547(1998) [PubMed] [Europe PMC] [Abstract]

"Protein C inhibitor may modulate human sperm-oocyte interactions."
Biol. Reprod. 58:670-677(1998) [PubMed] [Europe PMC] [Abstract]

"Protein C inhibitor secreted from activated platelets efficiently inhibits activated protein C on phosphatidylethanolamine of platelet membrane and microvesicles."
J. Biol. Chem. 273:11281-11287(1998) [PubMed] [Europe PMC] [Abstract]

"Functionally inactive protein C inhibitor in seminal plasma may be associated with infertility."
Mol. Hum. Reprod. 5:513-519(1999) [PubMed] [Europe PMC] [Abstract]

"Binding of retinoic acid by the inhibitory serpin protein C inhibitor."
Eur. J. Biochem. 268:5989-5996(2001) [PubMed] [Europe PMC] [Abstract]

"Regulation of carcinoma cell invasion by protein C inhibitor whose expression is decreased in renal cell carcinoma."
Int. J. Cancer 108:516-523(2004) [PubMed] [Europe PMC] [Abstract]

"Mouse DESC1 is located within a cluster of seven DESC1-like genes and encodes a type II transmembrane serine protease that forms serpin inhibitory complexes."
J. Biol. Chem. 279:46981-46994(2004) [PubMed] [Europe PMC] [Abstract]

"Characterization of a novel human protein C inhibitor (PCI) gene transgenic mouse useful for studying the role of PCI in physiological and pathological conditions."
J. Thromb. Haemost. 2:949-961(2004) [PubMed] [Europe PMC] [Abstract]

"Screening for N-glycosylated proteins by liquid chromatography mass spectrometry."
Proteomics 4:454-465(2004) [PubMed] [Europe PMC] [Abstract]

"Matriptase-3 is a novel phylogenetically preserved membrane-anchored serine protease with broad serpin reactivity."
Biochem. J. 390:231-242(2005) [PubMed] [Europe PMC] [Abstract]

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

"Immunolocalization of protein C inhibitor in differentiation of human epidermal keratinocytes."
Acta Histochem. 109:461-467(2007) [PubMed] [Europe PMC] [Abstract]

"N-glycans and the N terminus of protein C inhibitor affect the cofactor-enhanced rates of thrombin inhibition."
J. Biol. Chem. 283:18601-18611(2008) [PubMed] [Europe PMC] [Abstract]

"Molecular basis of thrombin recognition by protein C inhibitor revealed by the 1.6-A structure of the heparin-bridged complex."
Proc. Natl. Acad. Sci. U.S.A. 105:4661-4666(2008) [PubMed] [Europe PMC] [Abstract]

"Further insight into the roles of the glycans attached to human blood protein C inhibitor."
Biochem. Biophys. Res. Commun. 403:198-202(2010) [PubMed] [Europe PMC] [Abstract]

"Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."
Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]

"Elucidating the structural chemistry of glycosaminoglycan recognition by protein C inhibitor."
Proc. Natl. Acad. Sci. U.S.A. 87:8506-8510(1990) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of protein C inhibitor provides insights into hormone binding and heparin activation."
Structure 11:205-215(2003) [PubMed] [Europe PMC] [Abstract]

"Structure of native protein C inhibitor provides insight into its multiple functions."
J. Biol. Chem. 282:13759-13768(2007) [PubMed] [Europe PMC] [Abstract]

"The heparin binding site of protein C inhibitor is protease-dependent."
J. Biol. Chem. 283:36039-36045(2008) [PubMed] [Europe PMC] [Abstract]

"Characterization of single-nucleotide polymorphisms in coding regions of human genes."
Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract]

Erratum
Nat. Genet. 23:373-373(1999)