Myosin IC (MYO1C)

MMI-beta; MMIb; NMI; myr2

SPN	T350
HGNC	7597
MGI	106612
PubMed	19046570
RGD	620443
UniProt	O00159
Wiki	MYO1C

Myosin-Ic is a member of the unconventional myosin protein family, which are actin-based molecular motors. The protein is found in the cytoplasm, and one isoform with a unique N-terminus is also found in the nucleus. The nuclear isoform associates with RNA polymerase I and II and functions in transcription initiation.

The mouse ortholog of this protein also functions in intracellular vesicle transport to the plasma membrane. Multiple transcript variants encoding different isoforms have been found for this gene. The related gene myosin IE has been referred to as myosin IC in the literature, but it is a distinct locus on chromosome 19.

Reference

"Cloning of the genes encoding two murine and human cochlear unconventional type I myosins."
Genomics 40:332-341(1997) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

, Submitted (FEB-2008) to UniProtKB

"Nuclear distribution of actin and myosin I depends on transcriptional activity of the cell."
Histochem. Cell Biol. 124:347-358(2005) [PubMed] [Europe PMC] [Abstract]

"Small ribosomal subunits associate with nuclear myosin and actin in transit to the nuclear pores."
FASEB J. 20:1901-1903(2006) [PubMed] [Europe PMC] [Abstract]

"The WSTF-SNF2h chromatin remodeling complex interacts with several nuclear proteins in transcription."
J. Biol. Chem. 281:16264-16271(2006) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Identification and characterization of a novel myosin Ic isoform that localizes to the nucleus."
Cytoskeleton 69:555-565(2012) [PubMed] [Europe PMC] [Abstract]

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of human myosin 1c - the motor in GLUT4 exocytosis: implications for Ca(2+)-regulation and 14-3-3 binding."
J. Mol. Biol. 426:2070-2081(2014) [PubMed] [Europe PMC] [Abstract]