Mitogen Activated Protein Kinase Kinase 3 (MAP2K3)

MAPKK3; MEK3; MKK3; PRKMK3; SKK2; MAPK/ERK kinase 3; Stress-activated protein kinase kinase 2; Dual specificity mitogen-activated protein kinase kinase 3

SPN	T221
HGNC	6843
MGI	1346868
PubMed	21137025
RGD	1306620
UniProt	P46734
Wiki	MAP2K3

MAP2K3 is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene.

Reference

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