Mitogen Activated Protein Kinase Kinase 4 (MAP2K4)

JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4; SEK1; SERK1; SKK1; c-Jun N-terminal kinase kinase 1; JNK-activating kinase 1; Stress-activated protein kinase kinase 1

SPN	T220
HGNC	6844
MGI	1346869
PubMed	11754110
RGD	1307040
UniProt	P45985
Wiki	MAP2K4

Dual specificity mitogen-activated protein kinase kinase 4 is a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK1.

This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver.Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.

Reference

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