Protein Tyrosine Phosphatase, Non Receptor Type 2 (PTPN2)

PTPT; TC-PTP; TCELLPTP; TCPTP; T-cell protein-tyrosine phosphatase

SPN	T199
HGNC	9650
MGI	97806
PubMed	22377701
RGD	620710
UniProt	P17706
Wiki	PTPN2

Tyrosine-protein phosphatase non-receptor type 2 is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Three alternatively spliced variants of this gene, which encode isoforms differing at their extreme C-termini, have been described. The different C-termini are thought to determine the substrate specificity, as well as the cellular localization of the isoforms.

Reference

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