Protein Tyrosine Phosphatase, Non Receptor Type 6 (PTPN6)

HCP; HCPH; HPTP1C; SH-PTP1; SHP-1L; SHP1; Hematopoietic cell protein-tyrosine phosphatase; Protein-tyrosine phosphatase 1C; Protein-tyrosine phosphatase SHP-1

SPN	T195
HGNC	9658
MGI	96055
PubMed	24327268
RGD	620660
UniProt	P29350
Wiki	PTPN6

is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported.

Reference

"Protein tyrosine phosphatase containing SH2 domains: characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12-p13."
Mol. Cell. Biol. 12:836-846(1992) [PubMed] [Europe PMC] [Abstract]

"A protein-tyrosine phosphatase with sequence similarity to the SH2 domain of the protein-tyrosine kinases."
Nature 352:736-739(1991) [PubMed] [Europe PMC] [Abstract]

Erratum
Nature 353:868-868(1991)

"Isolation of a src homology 2-containing tyrosine phosphatase."
Proc. Natl. Acad. Sci. U.S.A. 89:1123-1127(1992) [PubMed] [Europe PMC] [Abstract]

"Human protein tyrosine phosphatase 1C (PTPN6) gene structure: alternate promoter usage and exon skipping generate multiple transcripts."
Genomics 27:165-173(1995) [PubMed] [Europe PMC] [Abstract]

"Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination."
Genome Res. 7:268-280(1997) [PubMed] [Europe PMC] [Abstract]

"Human 70-kDa SHP-1L differs from 68-kDa SHP-1 in its C-terminal structure and catalytic activity."
J. Biol. Chem. 274:28301-28307(1999) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The finished DNA sequence of human chromosome 12."
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Tyrosine phosphorylation of an SH2-containing protein tyrosine phosphatase is coupled to platelet thrombin receptor via a pertussis toxin-sensitive heterotrimeric G-protein."
EMBO J. 14:2519-2526(1995) [PubMed] [Europe PMC] [Abstract]

"A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules."
Immunity 7:273-282(1997) [PubMed] [Europe PMC] [Abstract]

"The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes."
Eur. J. Immunol. 28:3423-3434(1998) [PubMed] [Europe PMC] [Abstract]

"High expression of inhibitory receptor SHPS-1 and its association with protein tyrosine phosphatase SHP-1 in macrophages."
J. Biol. Chem. 273:22719-22728(1998) [PubMed] [Europe PMC] [Abstract]

"Functional interaction between SHPTP1 and the Lyn tyrosine kinase in the apoptotic response to DNA damage."
J. Biol. Chem. 274:34663-34668(1999) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning and characterization of SPAP1, an inhibitory receptor."
Biochem. Biophys. Res. Commun. 280:768-775(2001) [PubMed] [Europe PMC] [Abstract]

"Distinct interactions of the X-linked lymphoproliferative syndrome gene product SAP with cytoplasmic domains of members of the CD2 receptor family."
Clin. Immunol. 100:15-23(2001) [PubMed] [Europe PMC] [Abstract]

"Negative regulation of Ros receptor tyrosine kinase signaling. An epithelial function of the SH2 domain protein tyrosine phosphatase SHP-1."
J. Cell Biol. 152:325-334(2001) [PubMed] [Europe PMC] [Abstract]

"The inhibitory potential of Fc receptor homolog 4 on memory B cells."
Proc. Natl. Acad. Sci. U.S.A. 100:13489-13494(2003) [PubMed] [Europe PMC] [Abstract]

"IgSF13, a novel human inhibitory receptor of the immunoglobulin superfamily, is preferentially expressed in dendritic cells and monocytes."
Biochem. Biophys. Res. Commun. 319:920-928(2004) [PubMed] [Europe PMC] [Abstract]

"Signal transduction via the stem cell factor receptor/c-Kit."
Cell. Mol. Life Sci. 61:2535-2548(2004) [PubMed] [Europe PMC] [Abstract]

"Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor."
Biochem. Biophys. Res. Commun. 337:1-13(2005) [PubMed] [Europe PMC] [Abstract]

"An essential function for beta-arrestin 2 in the inhibitory signaling of natural killer cells."
Nat. Immunol. 9:898-907(2008) [PubMed] [Europe PMC] [Abstract]

"The nuclear localization of 3'-phosphoinositide-dependent kinase-1 is dependent on its association with the protein tyrosine phosphatase SHP-1."
Cell. Signal. 21:1634-1644(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Compartmentalized CDK2 is connected with SHP-1 and beta-catenin and regulates insulin internalization."
Cell. Signal. 23:911-919(2011) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of the catalytic domain of protein-tyrosine phosphatase SHP-1."
J. Biol. Chem. 273:28199-28207(1998) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of human protein-tyrosine phosphatase SHP-1."
J. Biol. Chem. 278:6516-6520(2003) [PubMed] [Europe PMC] [Abstract]

"Solution structures of the SH2 domain of human protein-tyrosine phosphatase SHP-1."
Submitted (NOV-2005) to the PDB data bank

"Crystal structure of human protein tyrosine phosphatase SHP-1 in the open conformation."
J. Cell. Biochem. 112:2062-2071(2011) [PubMed] [Europe PMC] [Abstract]