ATP Binding Cassette Transporter C4 (ABCC4)
ABC-C4; MRP4; MOATB; Canalicular Multispecific Organic Anion Transporter B; Multidrug Resistance-Associated Protein 4; Multi-specific organic anion transporter B
- ABCC4, also known as MRP4, belongs to a large family of transmembrane proteins involved in active transport of substrates out of cells. ABCC4 acts as an independent regulator of intracellular cyclic nucleotide levels and as a mediator of cAMP-dependent signal transduction to the nucleus.
- The insertion was attributed to 2 additional exons, designated 1a and 1b, that produced premature termination codons (PTCs). A comparison of human, monkey, and rodent ABCC4 genes revealed that these same PTC-producing exons were also highly conserved in evolution. In vitro inhibition of protein synthesis (using puromycin or anisomycin) selectively reduced nonsense-mediated mRNA decay of PTC-containing ABCC4 transcripts in all cell lines tested.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT160Hu01 | Recombinant ATP Binding Cassette Transporter C4 (ABCC4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT160Hu01 | Monoclonal Antibody to ATP Binding Cassette Transporter C4 (ABCC4) | WB; IHC; ICC; IP. |
| PAT160Hu01 | Polyclonal Antibody to ATP Binding Cassette Transporter C4 (ABCC4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT160Hu01 | CLIA Kit for ATP Binding Cassette Transporter C4 (ABCC4) | CLIA assay for Antigen Detection |
| ELT160Hu01 | ELISA Kit for ATP Binding Cassette Transporter C4 (ABCC4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT160Mu01 | Recombinant ATP Binding Cassette Transporter C4 (ABCC4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT160Mu01 | Monoclonal Antibody to ATP Binding Cassette Transporter C4 (ABCC4) | WB; IHC; ICC; IP. |
| PAT160Mu01 | Polyclonal Antibody to ATP Binding Cassette Transporter C4 (ABCC4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT160Mu01 | CLIA Kit for ATP Binding Cassette Transporter C4 (ABCC4) | CLIA assay for Antigen Detection |
| ELT160Mu01 | ELISA Kit for ATP Binding Cassette Transporter C4 (ABCC4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT160Ra01 | Recombinant ATP Binding Cassette Transporter C4 (ABCC4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT160Ra01 | Monoclonal Antibody to ATP Binding Cassette Transporter C4 (ABCC4) | WB; IHC; ICC; IP. |
| PAT160Ra01 | Polyclonal Antibody to ATP Binding Cassette Transporter C4 (ABCC4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT160Ra01 | CLIA Kit for ATP Binding Cassette Transporter C4 (ABCC4) | CLIA assay for Antigen Detection |
| ELT160Ra01 | ELISA Kit for ATP Binding Cassette Transporter C4 (ABCC4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT160Ca01 | Recombinant ATP Binding Cassette Transporter C4 (ABCC4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT160Ca01 | Monoclonal Antibody to ATP Binding Cassette Transporter C4 (ABCC4) | WB; IHC; ICC; IP. |
| PAT160Ca01 | Polyclonal Antibody to ATP Binding Cassette Transporter C4 (ABCC4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT160Ca01 | CLIA Kit for ATP Binding Cassette Transporter C4 (ABCC4) | CLIA assay for Antigen Detection |
| ELT160Ca01 | ELISA Kit for ATP Binding Cassette Transporter C4 (ABCC4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT160Po01 | Recombinant ATP Binding Cassette Transporter C4 (ABCC4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT160Po01 | Monoclonal Antibody to ATP Binding Cassette Transporter C4 (ABCC4) | WB; IHC; ICC; IP. |
| PAT160Po01 | Polyclonal Antibody to ATP Binding Cassette Transporter C4 (ABCC4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT160Po01 | CLIA Kit for ATP Binding Cassette Transporter C4 (ABCC4) | CLIA assay for Antigen Detection |
| ELT160Po01 | ELISA Kit for ATP Binding Cassette Transporter C4 (ABCC4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT160Bo01 | Recombinant ATP Binding Cassette Transporter C4 (ABCC4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT160Bo01 | Monoclonal Antibody to ATP Binding Cassette Transporter C4 (ABCC4) | WB; IHC; ICC; IP. |
| PAT160Bo01 | Polyclonal Antibody to ATP Binding Cassette Transporter C4 (ABCC4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT160Bo01 | CLIA Kit for ATP Binding Cassette Transporter C4 (ABCC4) | CLIA assay for Antigen Detection |
| ELT160Bo01 | ELISA Kit for ATP Binding Cassette Transporter C4 (ABCC4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT160Rb01 | Recombinant ATP Binding Cassette Transporter C4 (ABCC4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT160Rb01 | Monoclonal Antibody to ATP Binding Cassette Transporter C4 (ABCC4) | WB; IHC; ICC; IP. |
| PAT160Rb01 | Polyclonal Antibody to ATP Binding Cassette Transporter C4 (ABCC4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT160Rb01 | CLIA Kit for ATP Binding Cassette Transporter C4 (ABCC4) | CLIA assay for Antigen Detection |
| ELT160Rb01 | ELISA Kit for ATP Binding Cassette Transporter C4 (ABCC4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT160Mo01 | Recombinant ATP Binding Cassette Transporter C4 (ABCC4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT160Mo01 | Monoclonal Antibody to ATP Binding Cassette Transporter C4 (ABCC4) | WB; IHC; ICC; IP. |
| PAT160Mo01 | Polyclonal Antibody to ATP Binding Cassette Transporter C4 (ABCC4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT160Mo01 | CLIA Kit for ATP Binding Cassette Transporter C4 (ABCC4) | CLIA assay for Antigen Detection |
| ELT160Mo01 | ELISA Kit for ATP Binding Cassette Transporter C4 (ABCC4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Isolation of MOAT-B, a widely expressed multidrug resistance-associated protein/canalicular multispecific organic anion transporter-related transporter."
Cancer Res. 58:2741-2747(1998) [PubMed] [Europe PMC] [Abstract]
"Expression of MRP4 confers resistance to ganciclovir and compromises bystander cell killing."
J. Biol. Chem. 277:38998-39004(2002) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and analysis of human chromosome 13."
Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines."
Cancer Res. 57:3537-3547(1997) [PubMed] [Europe PMC] [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"Sorting nexin 27 interacts with multidrug resistance-associated protein 4 (MRP4) and mediates internalization of MRP4."
J. Biol. Chem. 287:15054-15065(2012) [PubMed] [Europe PMC] [Abstract]
"6-mercaptopurine and 9-(2-phosphonyl-methoxyethyl) adenine (PMEA) transport altered by two missense mutations in the drug transporter gene ABCC4."
Hum. Mutat. 29:659-669(2008) [PubMed] [Europe PMC] [Abstract]
"A Japanese-specific allele in the GALNT11 gene."
Leg. Med. 12:208-211(2010) [PubMed] [Europe PMC] [Abstract]