Phospholipase C Zeta 1 (PLCz1)

NYD-SP27; PLCzeta; Testis-development protein NYD-SP27; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1

SPN	S929
HGNC	19218
MGI	2150308
PubMed	17933795
RGD	1359567
UniProt	Q86YW0

PLCz1 Expressed specifically in testis. Weakly expressed in pancreatic-duct cells. Up-regulated in pancreatic-duct cells from patients with cystic fibrosis.The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca²⁺-dependent manner. Triggers intracellular Ca²⁺ oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion.

Reference

"Sperm phospholipase Czeta from humans and cynomolgus monkeys triggers Ca2+ oscillations, activation and development of mouse oocytes."
Reproduction 124:611-623(2002) [PubMed] [Europe PMC] [Abstract].

"Rescue of defective pancreatic secretion in cystic-fibrosis cells by suppression of a novel isoform of phospholipase C."
Lancet 362:2059-2065(2003) [PubMed] [Europe PMC] [Abstract].

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract].

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Phospholipase Czeta causes Ca2+ oscillations and parthenogenetic activation of human oocytes."
Reproduction 128:697-702(2004) [PubMed] [Europe PMC] [Abstract]