Protein Phosphatase 2A Activator, Regulatory Subunit 4 (PPP2R4)

PP2A; PR53; PTPA; Phosphotyrosyl Phosphatase Activator; PP2A Phosphatase Activator; PP2A, subunit B', PR53 isoform; Serine/threonine-protein phosphatase 2A activator

SPN	S755
HGNC	9308
MGI	1346006
PubMed	22892532
RGD	1308354
UniProt	Q15257
Wiki	PPP2R4

Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. PPP2R4 encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms.

Reference

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