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Ephrin B1 (EFNB1)

CFND; CFNS; EFL3; EPLG2; Elk-L; LERK2; EPH-related receptor tyrosine kinase ligand 2; Craniofrontonasal Syndrome(Craniofrontonasal Dysplasia)

Ephrin-B1 is a member of the ephrin family. The encoded protein is a type I membrane protein and a ligand of Eph-related receptor tyrosine kinases. It may play a role in cell adhesion and function in the development or maintenance of the nervous system.Disruption of EphB2 and EphB3 genes revealed that their gene products restrict cell intermingling and allocate cell populations within the intestinal epithelium. In EphB2/EphB3 null mice, the proliferative and differentiated populations intermingled. In adult EphB3 -/- mice, Paneth cells did not follow their downward migratory path, but scattered along crypt and villus. The authors concluded that, in the intestinal epithelium, beta-catenin and TCF couple proliferation and differentiation to the sorting of cell populations through the EphB/ephrin B system.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS667Hu01 Recombinant Ephrin B1 (EFNB1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS667Hu01 Monoclonal Antibody to Ephrin B1 (EFNB1) WB; IHC; ICC; IP.
PAS667Hu01 Polyclonal Antibody to Ephrin B1 (EFNB1) WB; IHC; ICC; IF.
Assay Kits CLS667Hu01 CLIA Kit for Ephrin B1 (EFNB1) CLIA assay for Antigen Detection
ELS667Hu01 ELISA Kit for Ephrin B1 (EFNB1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS667Mu01 Recombinant Ephrin B1 (EFNB1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS667Mu01 Monoclonal Antibody to Ephrin B1 (EFNB1) WB; IHC; ICC; IP.
PAS667Mu01 Polyclonal Antibody to Ephrin B1 (EFNB1) WB; IHC; ICC; IF.
Assay Kits CLS667Mu01 CLIA Kit for Ephrin B1 (EFNB1) CLIA assay for Antigen Detection
ELS667Mu01 ELISA Kit for Ephrin B1 (EFNB1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS667Ra01 Recombinant Ephrin B1 (EFNB1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS667Ra01 Monoclonal Antibody to Ephrin B1 (EFNB1) WB; IHC; ICC; IP.
PAS667Ra01 Polyclonal Antibody to Ephrin B1 (EFNB1) WB; IHC; ICC; IF.
Assay Kits CLS667Ra01 CLIA Kit for Ephrin B1 (EFNB1) CLIA assay for Antigen Detection
ELS667Ra01 ELISA Kit for Ephrin B1 (EFNB1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS667Ca01 Recombinant Ephrin B1 (EFNB1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS667Ca01 Monoclonal Antibody to Ephrin B1 (EFNB1) WB; IHC; ICC; IP.
PAS667Ca01 Polyclonal Antibody to Ephrin B1 (EFNB1) WB; IHC; ICC; IF.
Assay Kits CLS667Ca01 CLIA Kit for Ephrin B1 (EFNB1) CLIA assay for Antigen Detection
ELS667Ca01 ELISA Kit for Ephrin B1 (EFNB1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS667Po01 Recombinant Ephrin B1 (EFNB1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS667Po01 Monoclonal Antibody to Ephrin B1 (EFNB1) WB; IHC; ICC; IP.
PAS667Po01 Polyclonal Antibody to Ephrin B1 (EFNB1) WB; IHC; ICC; IF.
Assay Kits CLS667Po01 CLIA Kit for Ephrin B1 (EFNB1) CLIA assay for Antigen Detection
ELS667Po01 ELISA Kit for Ephrin B1 (EFNB1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS667Bo01 Recombinant Ephrin B1 (EFNB1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS667Bo01 Monoclonal Antibody to Ephrin B1 (EFNB1) WB; IHC; ICC; IP.
PAS667Bo01 Polyclonal Antibody to Ephrin B1 (EFNB1) WB; IHC; ICC; IF.
Assay Kits CLS667Bo01 CLIA Kit for Ephrin B1 (EFNB1) CLIA assay for Antigen Detection
ELS667Bo01 ELISA Kit for Ephrin B1 (EFNB1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS667Rb01 Recombinant Ephrin B1 (EFNB1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS667Rb01 Monoclonal Antibody to Ephrin B1 (EFNB1) WB; IHC; ICC; IP.
PAS667Rb01 Polyclonal Antibody to Ephrin B1 (EFNB1) WB; IHC; ICC; IF.
Assay Kits CLS667Rb01 CLIA Kit for Ephrin B1 (EFNB1) CLIA assay for Antigen Detection
ELS667Rb01 ELISA Kit for Ephrin B1 (EFNB1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS667Mo01 Recombinant Ephrin B1 (EFNB1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS667Mo01 Monoclonal Antibody to Ephrin B1 (EFNB1) WB; IHC; ICC; IP.
PAS667Mo01 Polyclonal Antibody to Ephrin B1 (EFNB1) WB; IHC; ICC; IF.
Assay Kits CLS667Mo01 CLIA Kit for Ephrin B1 (EFNB1) CLIA assay for Antigen Detection
ELS667Mo01 ELISA Kit for Ephrin B1 (EFNB1) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Molecular characterization of a family of ligands for eph-related tyrosine kinase receptors."
EMBO J. 13:3757-3762(1994) [PubMed] [Europe PMC] [Abstract]

"Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity."
Science 266:816-819(1994) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of the human X chromosome."
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]

"EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains."
Neuron 22:511-524(1999) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"EphrinB1 interacts with the transcriptional co-repressor Groucho/xTLE4."
BMB Rep. 44:199-204(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Mutations of the ephrin-B1 gene cause craniofrontonasal syndrome."
Am. J. Hum. Genet. 74:1209-1215(2004) [PubMed] [Europe PMC] [Abstract]

"Mutations of ephrin-B1 (EFNB1), a marker of tissue boundary formation, cause craniofrontonasal syndrome."
Proc. Natl. Acad. Sci. U.S.A. 101:8652-8657(2004) [PubMed] [Europe PMC] [Abstract]

"Twenty-six novel EFNB1 mutations in familial and sporadic craniofrontonasal syndrome (CFNS)."
Hum. Mutat. 26:113-118(2005) [PubMed] [Europe PMC] [Abstract]