Serum/Glucocorticoid Regulated Kinase 3 (SGK3)

CISK; SGKL; Cytokine-independent survival kinase; Serum/glucocorticoid-regulated kinase-like; Serine/threonine-protein kinase Sgk3

SPN	S224
HGNC	10812
MGI	2182368
PubMed	21084382
RGD	620242
UniProt	Q96BR1
Wiki	SGK3

Sgk3 is a member of the Ser/Thr protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain. The protein phosphorylates several target proteins and has a role in neutral amino acid transport and activation of potassium and chloride channels. SGKL contains the highly conserved catalytic structure ala262-pro263-glu264 in motif 8 and the conserved leu126 in motif 2, which transfers the phosphoryl group during phosphorylation. SGKL shares about 66% amino acid identity with human and rat SGK1. Northern blot analysis revealed a 4.4-kb transcript in all tissues examined. Expression was highest in lung, intermediate in liver, peripheral blood leukocytes, placenta, thymus, brain, kidney, pancreas, and colon, and low in heart, ovary, testis, prostate, small intestine, spleen, and skeletal muscle.

Reference

"Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase."
Biochem. J. 344:189-197(1999) [PubMed] [Europe PMC] [Abstract]

"Cloning and mapping of a novel human Serum/Glucocorticoid regulated kinase-like gene, SGKL, to chromosome 8q12.3-q13.1."
Genomics 62:95-97(1999) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Human serum and glucocorticoid-inducible kinase-like kinase (SGKL) phosphorylates glycogen syntheses kinase 3 beta (GSK-3beta) at serine-9 through direct interaction."
Biochem. Biophys. Res. Commun. 293:1191-1196(2002) [PubMed] [Europe PMC] [Abstract]

"Activation of Na+/K+-ATPase by the serum and glucocorticoid-dependent kinase isoforms."
Kidney Blood Press. Res. 25:370-374(2002) [PubMed] [Europe PMC] [Abstract]

"K(+) channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK."
Pflugers Arch. 445:60-66(2002) [PubMed] [Europe PMC] [Abstract]

"Serum and glucocorticoid inducible kinases in the regulation of the cardiac sodium channel SCN5A."
Cardiovasc. Res. 57:1079-1084(2003) [PubMed] [Europe PMC] [Abstract]

"Regulation of the glutamate transporter EAAT1 by the ubiquitin ligase Nedd4-2 and the serum and glucocorticoid-inducible kinase isoforms SGK1/3 and protein kinase B."
J. Neurochem. 86:1181-1188(2003) [PubMed] [Europe PMC] [Abstract]

"Regulation of KCNE1-dependent K(+) current by the serum and glucocorticoid-inducible kinase (SGK) isoforms."
Pflugers Arch. 445:601-606(2003) [PubMed] [Europe PMC] [Abstract]

"The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel alpha,beta,gamma-ENaC."
Pflugers Arch. 445:693-696(2003) [PubMed] [Europe PMC] [Abstract]

"Regulation of intestinal phosphate cotransporter NaPi IIb by ubiquitin ligase Nedd4-2 and by serum- and glucocorticoid-dependent kinase 1."
Am. J. Physiol. 287:G143-G150(2004) [PubMed] [Europe PMC] [Abstract]

"Stimulation of renal Na+ dicarboxylate cotransporter 1 by Na+/H+ exchanger regulating factor 2, serum and glucocorticoid inducible kinase isoforms, and protein kinase B."
Biochem. Biophys. Res. Commun. 313:998-1003(2004) [PubMed] [Europe PMC] [Abstract]

"Regulation of the epithelial Ca2+ channel TRPV5 by the NHE regulating factor NHERF2 and the serum and glucocorticoid inducible kinase isoforms SGK1 and SGK3 expressed in Xenopus oocytes."
Cell. Physiol. Biochem. 14:203-212(2004) [PubMed] [Europe PMC] [Abstract]

"Peroxisomal targeting as a tool for assaying protein-protein interactions in the living cell: cytokine-independent survival kinase (CISK) binds PDK-1 in vivo in a phosphorylation-dependent manner."
J. Biol. Chem. 279:4794-4801(2004) [PubMed] [Europe PMC] [Abstract]

"Regulation of the voltage gated K+ channel Kv1.3 by the ubiquitin ligase Nedd4-2 and the serum and glucocorticoid inducible kinase SGK1."
J. Cell. Physiol. 199:194-199(2004) [PubMed] [Europe PMC] [Abstract]

"Regulation of CLC-Ka/barttin by the ubiquitin ligase Nedd4-2 and the serum- and glucocorticoid-dependent kinases."
Kidney Int. 66:1918-1925(2004) [PubMed] [Europe PMC] [Abstract]

"The serine/threonine kinases SGK1, 3 and PKB stimulate the amino acid transporter ASCT2."
Biochem. Biophys. Res. Commun. 331:272-277(2005) [PubMed] [Europe PMC] [Abstract]

"Regulation of the excitatory amino acid transporter EAAT5 by the serum and glucocorticoid dependent kinases SGK1 and SGK3."
Biochem. Biophys. Res. Commun. 329:738-742(2005) [PubMed] [Europe PMC] [Abstract]

"Stimulation of the creatine transporter SLC6A8 by the protein kinases SGK1 and SGK3."
Biochem. Biophys. Res. Commun. 334:742-746(2005) [PubMed] [Europe PMC] [Abstract]

"Upregulation of HERG channels by the serum and glucocorticoid inducible kinase isoform SGK3."
Cell. Physiol. Biochem. 18:177-186(2006) [PubMed] [Europe PMC] [Abstract]

"CISK attenuates degradation of the chemokine receptor CXCR4 via the ubiquitin ligase AIP4."
EMBO J. 25:3738-3749(2006) [PubMed] [Europe PMC] [Abstract]

"Role of the Phox homology domain and phosphorylation in activation of serum and glucocorticoid-regulated kinase-3."
J. Biol. Chem. 281:23978-23989(2006) [PubMed] [Europe PMC] [Abstract]

"Regulation of the epithelial calcium channel TRPV6 by the serum and glucocorticoid-inducible kinase isoforms SGK1 and SGK3."
FEBS Lett. 581:5586-5590(2007) [PubMed] [Europe PMC] [Abstract]

"Identification of Flightless-I as a substrate of the cytokine-independent survival kinase CISK."
J. Biol. Chem. 284:14377-14385(2009) [PubMed] [Europe PMC] [Abstract]

"The serum and glucocorticoid inducible kinases SGK1-3 stimulate the neutral amino acid transporter SLC6A19."
Cell. Physiol. Biochem. 25:723-732(2010) [PubMed] [Europe PMC] [Abstract]

"Serum- and glucocorticoid-induced kinase 3 in recycling endosomes mediates acute activation of Na+/H+ exchanger NHE3 by glucocorticoids."
Mol. Biol. Cell 22:3812-3825(2011) [PubMed] [Europe PMC] [Abstract]

"SGK3 is an estrogen-inducible kinase promoting estrogen-mediated survival of breast cancer cells."
Mol. Endocrinol. 25:72-82(2011) [PubMed] [Europe PMC] [Abstract]

"Sgk kinases and their role in epithelial transport."
Annu. Rev. Physiol. 68:461-490(2006) [PubMed] [Europe PMC] [Abstract]

"Second AKT: the rise of SGK in cancer signalling."
Growth Factors 28:394-408(2010) [PubMed] [Europe PMC] [Abstract]

"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]

"Patterns of somatic mutation in human cancer genomes."
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]