Protein Inhibitor Of Activated STAT 3 (PIAS3)
ZMIZ5; Zinc Finger,MIZ-Type Containing 5; E3 SUMO-protein ligase PIAS3
E3 SUMO-protein ligase PIAS3 is a member of the PIAS family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It directly binds to several transcription factors and either blocks or enhances their activity.
Alternatively spliced transcript variants of this gene have been identified, but the full-length nature of some of these variants has not been determined.Gel-shift assays showed that PIAS3 can block MITF DNA-binding activity, and cotransfection of MITF and PIAS3 in NIH 3T3 cells inhibited MITF-driven transcription activity. Interaction between PIAS3 and MITF was independent of STAT3 binding.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS211Hu01 | Recombinant Protein Inhibitor Of Activated STAT 3 (PIAS3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS211Hu01 | Monoclonal Antibody to Protein Inhibitor Of Activated STAT 3 (PIAS3) | WB; IHC; ICC; IP. |
| PAS211Hu01 | Polyclonal Antibody to Protein Inhibitor Of Activated STAT 3 (PIAS3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS211Hu01 | CLIA Kit for Protein Inhibitor Of Activated STAT 3 (PIAS3) | CLIA assay for Antigen Detection |
| ELS211Hu01 | ELISA Kit for Protein Inhibitor Of Activated STAT 3 (PIAS3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS211Mu01 | Recombinant Protein Inhibitor Of Activated STAT 3 (PIAS3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS211Mu01 | Monoclonal Antibody to Protein Inhibitor Of Activated STAT 3 (PIAS3) | WB; IHC; ICC; IP. |
| PAS211Mu01 | Polyclonal Antibody to Protein Inhibitor Of Activated STAT 3 (PIAS3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS211Mu01 | CLIA Kit for Protein Inhibitor Of Activated STAT 3 (PIAS3) | CLIA assay for Antigen Detection |
| ELS211Mu01 | ELISA Kit for Protein Inhibitor Of Activated STAT 3 (PIAS3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS211Ra01 | Recombinant Protein Inhibitor Of Activated STAT 3 (PIAS3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS211Ra01 | Monoclonal Antibody to Protein Inhibitor Of Activated STAT 3 (PIAS3) | WB; IHC; ICC; IP. |
| PAS211Ra01 | Polyclonal Antibody to Protein Inhibitor Of Activated STAT 3 (PIAS3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS211Ra01 | CLIA Kit for Protein Inhibitor Of Activated STAT 3 (PIAS3) | CLIA assay for Antigen Detection |
| ELS211Ra01 | ELISA Kit for Protein Inhibitor Of Activated STAT 3 (PIAS3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS211Ca01 | Recombinant Protein Inhibitor Of Activated STAT 3 (PIAS3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS211Ca01 | Monoclonal Antibody to Protein Inhibitor Of Activated STAT 3 (PIAS3) | WB; IHC; ICC; IP. |
| PAS211Ca01 | Polyclonal Antibody to Protein Inhibitor Of Activated STAT 3 (PIAS3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS211Ca01 | CLIA Kit for Protein Inhibitor Of Activated STAT 3 (PIAS3) | CLIA assay for Antigen Detection |
| ELS211Ca01 | ELISA Kit for Protein Inhibitor Of Activated STAT 3 (PIAS3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS211Po01 | Recombinant Protein Inhibitor Of Activated STAT 3 (PIAS3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS211Po01 | Monoclonal Antibody to Protein Inhibitor Of Activated STAT 3 (PIAS3) | WB; IHC; ICC; IP. |
| PAS211Po01 | Polyclonal Antibody to Protein Inhibitor Of Activated STAT 3 (PIAS3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS211Po01 | CLIA Kit for Protein Inhibitor Of Activated STAT 3 (PIAS3) | CLIA assay for Antigen Detection |
| ELS211Po01 | ELISA Kit for Protein Inhibitor Of Activated STAT 3 (PIAS3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS211Bo01 | Recombinant Protein Inhibitor Of Activated STAT 3 (PIAS3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS211Bo01 | Monoclonal Antibody to Protein Inhibitor Of Activated STAT 3 (PIAS3) | WB; IHC; ICC; IP. |
| PAS211Bo01 | Polyclonal Antibody to Protein Inhibitor Of Activated STAT 3 (PIAS3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS211Bo01 | CLIA Kit for Protein Inhibitor Of Activated STAT 3 (PIAS3) | CLIA assay for Antigen Detection |
| ELS211Bo01 | ELISA Kit for Protein Inhibitor Of Activated STAT 3 (PIAS3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS211Rb01 | Recombinant Protein Inhibitor Of Activated STAT 3 (PIAS3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS211Rb01 | Monoclonal Antibody to Protein Inhibitor Of Activated STAT 3 (PIAS3) | WB; IHC; ICC; IP. |
| PAS211Rb01 | Polyclonal Antibody to Protein Inhibitor Of Activated STAT 3 (PIAS3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS211Rb01 | CLIA Kit for Protein Inhibitor Of Activated STAT 3 (PIAS3) | CLIA assay for Antigen Detection |
| ELS211Rb01 | ELISA Kit for Protein Inhibitor Of Activated STAT 3 (PIAS3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS211Mo01 | Recombinant Protein Inhibitor Of Activated STAT 3 (PIAS3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS211Mo01 | Monoclonal Antibody to Protein Inhibitor Of Activated STAT 3 (PIAS3) | WB; IHC; ICC; IP. |
| PAS211Mo01 | Polyclonal Antibody to Protein Inhibitor Of Activated STAT 3 (PIAS3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS211Mo01 | CLIA Kit for Protein Inhibitor Of Activated STAT 3 (PIAS3) | CLIA assay for Antigen Detection |
| ELS211Mo01 | ELISA Kit for Protein Inhibitor Of Activated STAT 3 (PIAS3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Isolation and chromosomal assignment of a human gene encoding protein inhibitor of activated STAT3 (PIAS3)."
J. Hum. Genet. 44:193-196(1999) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
"Specific inhibition of Stat3 signal transduction by PIAS3."
Science 278:1803-1805(1997) [PubMed] [Europe PMC] [Abstract]
"Protein inhibitor of activated STAT3 regulates androgen receptor signaling in prostate carcinoma cells."
Biochem. Biophys. Res. Commun. 278:9-13(2000) [PubMed] [Europe PMC] [Abstract]
"The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3."
EMBO J. 19:5845-5855(2000) [PubMed] [Europe PMC] [Abstract]
"ATBF1 enhances the suppression of STAT3 signaling by interaction with PIAS3."
Biochem. Biophys. Res. Commun. 314:97-103(2004) [PubMed] [Europe PMC] [Abstract]
"Repression of the transactivating capacity of the oncoprotein PLAG1 by SUMOylation."
J. Biol. Chem. 279:36121-36131(2004) [PubMed] [Europe PMC] [Abstract]
"SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor antigen 1 (MTA1) synergistically regulate its transcriptional repressor function."
J. Biol. Chem. 286:43793-43808(2011) [PubMed] [Europe PMC] [Abstract]