Ubiquitin A 52 Residue Ribosomal Protein Fusion Product 1 (UBA52)

CEP52; HUBCEP52; RPL40; 60S Ribosomal Protein L40; Ubiquitin Carboxyl Extension Protein 52

SPN	S209
HGNC	12458
MGI	98887
PubMed	1850507
RGD	68344
UniProt	P62987
Wiki	UBA52

Ubiquitin is a highly conserved nuclear and cytoplasmic protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein.

UBA52 encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein L40 at the C terminus, a C-terminal extension protein (CEP). Multiple processed pseudogenes derived from this gene are present in the genome.

Reference

"The human ubiquitin-52 amino acid fusion protein gene shares several structural features with mammalian ribosomal protein genes."
Nucleic Acids Res. 19:1035-1040(1991) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

"Molecular conservation of 74 amino acid sequence of ubiquitin between cattle and man."
Nature 255:423-424(1975) [PubMed] [Europe PMC] [Abstract]