Cyclin Dependent Kinase 16 (CDK16)

PCTK1; PCTAIRE; PCTAIRE1; PCTGAIRE; Serine/Threonine-Protein Kinase PCTAIRE-1; PCTAIRE-motif protein kinase 1; Cell division protein kinase 16

SPN	S151
HGNC	8749
MGI	97516
PubMed	22184064
RGD	620584
UniProt	Q00536

CDK16 belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a role in signal transduction cascades in terminally differentiated cells. This gene is thought to escape X inactivation. Two transcript variants encoding the same protein have been found for this gene.

The 3 PCTAIRE kinases are 65% identical to one another (80% within the catalytic domain). PCTAIRE1 is ubiquitously expressed with the highest levels detected in the brain and testis. Human PCTAIRE cDNAs do not complement yeast cdc28 mutants and show other differences, suggesting that PCTAIRE kinases have different cellular functions from those described for CDC2.

Reference

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EMBO J. 11:2909-2917(1992) [PubMed] [Europe PMC] [Abstract]

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Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

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Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]

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"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"Large-scale proteomics analysis of the human kinome."
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"Analysis of substrate specificity and cyclin Y binding of PCTAIRE-1 kinase."
Cell. Signal. 24:2085-2094(2012) [PubMed] [Europe PMC] [Abstract]

"Brain-selective kinase 2 (BRSK2) phosphorylation on PCTAIRE1 negatively regulates glucose-stimulated insulin secretion in pancreatic beta-cells."
J. Biol. Chem. 287:30368-30375(2012) [PubMed] [Europe PMC] [Abstract]

"Cyclin-dependent kinase 16/PCTAIRE kinase 1 is activated by cyclin Y and is essential for spermatogenesis."
Mol. Cell. Biol. 32:868-879(2012) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of the PCTAIRE1 kinase in complex with indirubin e804."
Submitted (JUN-2010) to the PDB data bank