Glutamate Receptor, Metabotropic 1 (GRM1)
GPRC1A; GRM1A; MGLUR1; MGLUR1A; mGluR1
The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternative splice variants of the GRM1 gene have been described but their full-length nature has not been determined. Mice lacking functional glutamate receptor 1 were reported in 1994. By homologous recombination mediated gene targeting those mice became deficient in mGlu receptor 1 protein.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR991Hu01 | Recombinant Glutamate Receptor, Metabotropic 1 (GRM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR991Hu01 | Monoclonal Antibody to Glutamate Receptor, Metabotropic 1 (GRM1) | WB; IHC; ICC; IP. |
| PAR991Hu01 | Polyclonal Antibody to Glutamate Receptor, Metabotropic 1 (GRM1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR991Hu01 | CLIA Kit for Glutamate Receptor, Metabotropic 1 (GRM1) | CLIA assay for Antigen Detection |
| ELR991Hu01 | ELISA Kit for Glutamate Receptor, Metabotropic 1 (GRM1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR991Mu01 | Recombinant Glutamate Receptor, Metabotropic 1 (GRM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR991Mu01 | Monoclonal Antibody to Glutamate Receptor, Metabotropic 1 (GRM1) | WB; IHC; ICC; IP. |
| PAR991Mu01 | Polyclonal Antibody to Glutamate Receptor, Metabotropic 1 (GRM1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR991Mu01 | CLIA Kit for Glutamate Receptor, Metabotropic 1 (GRM1) | CLIA assay for Antigen Detection |
| ELR991Mu01 | ELISA Kit for Glutamate Receptor, Metabotropic 1 (GRM1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR991Ra01 | Recombinant Glutamate Receptor, Metabotropic 1 (GRM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR991Ra01 | Monoclonal Antibody to Glutamate Receptor, Metabotropic 1 (GRM1) | WB; IHC; ICC; IP. |
| PAR991Ra01 | Polyclonal Antibody to Glutamate Receptor, Metabotropic 1 (GRM1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR991Ra01 | CLIA Kit for Glutamate Receptor, Metabotropic 1 (GRM1) | CLIA assay for Antigen Detection |
| ELR991Ra01 | ELISA Kit for Glutamate Receptor, Metabotropic 1 (GRM1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR991Ca01 | Recombinant Glutamate Receptor, Metabotropic 1 (GRM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR991Ca01 | Monoclonal Antibody to Glutamate Receptor, Metabotropic 1 (GRM1) | WB; IHC; ICC; IP. |
| PAR991Ca01 | Polyclonal Antibody to Glutamate Receptor, Metabotropic 1 (GRM1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR991Ca01 | CLIA Kit for Glutamate Receptor, Metabotropic 1 (GRM1) | CLIA assay for Antigen Detection |
| ELR991Ca01 | ELISA Kit for Glutamate Receptor, Metabotropic 1 (GRM1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR991Po01 | Recombinant Glutamate Receptor, Metabotropic 1 (GRM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR991Po01 | Monoclonal Antibody to Glutamate Receptor, Metabotropic 1 (GRM1) | WB; IHC; ICC; IP. |
| PAR991Po01 | Polyclonal Antibody to Glutamate Receptor, Metabotropic 1 (GRM1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR991Po01 | CLIA Kit for Glutamate Receptor, Metabotropic 1 (GRM1) | CLIA assay for Antigen Detection |
| ELR991Po01 | ELISA Kit for Glutamate Receptor, Metabotropic 1 (GRM1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR991Bo01 | Recombinant Glutamate Receptor, Metabotropic 1 (GRM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR991Bo01 | Monoclonal Antibody to Glutamate Receptor, Metabotropic 1 (GRM1) | WB; IHC; ICC; IP. |
| PAR991Bo01 | Polyclonal Antibody to Glutamate Receptor, Metabotropic 1 (GRM1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR991Bo01 | CLIA Kit for Glutamate Receptor, Metabotropic 1 (GRM1) | CLIA assay for Antigen Detection |
| ELR991Bo01 | ELISA Kit for Glutamate Receptor, Metabotropic 1 (GRM1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR991Rb01 | Recombinant Glutamate Receptor, Metabotropic 1 (GRM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR991Rb01 | Monoclonal Antibody to Glutamate Receptor, Metabotropic 1 (GRM1) | WB; IHC; ICC; IP. |
| PAR991Rb01 | Polyclonal Antibody to Glutamate Receptor, Metabotropic 1 (GRM1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR991Rb01 | CLIA Kit for Glutamate Receptor, Metabotropic 1 (GRM1) | CLIA assay for Antigen Detection |
| ELR991Rb01 | ELISA Kit for Glutamate Receptor, Metabotropic 1 (GRM1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR991Mo01 | Recombinant Glutamate Receptor, Metabotropic 1 (GRM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR991Mo01 | Monoclonal Antibody to Glutamate Receptor, Metabotropic 1 (GRM1) | WB; IHC; ICC; IP. |
| PAR991Mo01 | Polyclonal Antibody to Glutamate Receptor, Metabotropic 1 (GRM1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR991Mo01 | CLIA Kit for Glutamate Receptor, Metabotropic 1 (GRM1) | CLIA assay for Antigen Detection |
| ELR991Mo01 | ELISA Kit for Glutamate Receptor, Metabotropic 1 (GRM1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Cloning and expression of a human metabotropic glutamate receptor 1 alpha: enhanced coupling on co-transfection with a glutamate transporter."
Mol. Pharmacol. 48:648-657(1995) [PubMed] [Europe PMC] [Abstract]
"Human metabotropic glutamate receptor 1: mRNA distribution, chromosome localization and functional expression of two splice variants."
Neuropharmacology 35:1649-1660(1996) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and analysis of human chromosome 6."
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Autosomal-recessive congenital cerebellar ataxia is caused by mutations in metabotropic glutamate receptor 1."
Am. J. Hum. Genet. 91:553-564(2012) [PubMed] [Europe PMC] [Abstract]
"Metabotropic glutamate receptor mGluR1 complexed with LY341495 antagonist."
Submitted (JUL-2011) to the PDB data bank
"Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator."
Science 344:58-64(2014) [PubMed] [Europe PMC] [Abstract]
"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]