Structural Maintenance Of Chromosomes Protein 3 (SMC3)

BMH; BAM; CSPG6; HCAP; SMC3L1; Chondroitin Sulfate Proteoglycan 6; Bamacan; Basement membrane-associated chondroitin proteoglycan; Chromosome-associated peptide

SPN	R933
HGNC	2468
MGI	1339795
PubMed	20832721
RGD	62006
UniProt	Q9UQE7
Wiki	SMC3

Structural maintenance of chromosomes 3 belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenance of chromosomes 3, is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis, enabling proper chromosome segregation.

Post-translational modification of the encoded protein by the addition of chondroitin sulfate chains gives rise to the secreted proteoglycan bamacan, an abundant basement membrane protein.

Reference

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