Catenin Beta Interacting Protein 1 (CTNNbIP1)
ICAT; Beta-Catenin-Interacting Protein ICAT; Inhibitor Of beta-Catenin And Tcf-4
CTNNBIP1 binds CTNNB1 and prevents interaction between CTNNB1 and TCF (T-cell transcription factor) family members. The encoded protein is a negative regulator of the Wnt signaling pathway.
The deduced mouse and human proteins are identical except for 2 amino acid changes. Northern blot analysis of mouse tissues detected a 2.6-kb transcript expressed at high levels in heart, brain, liver, and skeletal muscle, at low levels in kidney, testis, and lung, and at undetectable levels in spleen. Icat was also expressed at fairly constant levels during embryonic mouse development.ICAT contains a 3-helix bundle that binds armadillo repeats 10 to 12 and a C-terminal tail that, like TCF and E-cadherin, binds in the groove formed by armadillo repeats 5 to 9 of CTNNB1.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR901Hu01 | Recombinant Catenin Beta Interacting Protein 1 (CTNNbIP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR901Hu01 | Monoclonal Antibody to Catenin Beta Interacting Protein 1 (CTNNbIP1) | WB; IHC; ICC; IP. |
| PAR901Hu01 | Polyclonal Antibody to Catenin Beta Interacting Protein 1 (CTNNbIP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR901Hu01 | CLIA Kit for Catenin Beta Interacting Protein 1 (CTNNbIP1) | CLIA assay for Antigen Detection |
| ELR901Hu01 | ELISA Kit for Catenin Beta Interacting Protein 1 (CTNNbIP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR901Mu01 | Recombinant Catenin Beta Interacting Protein 1 (CTNNbIP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR901Mu01 | Monoclonal Antibody to Catenin Beta Interacting Protein 1 (CTNNbIP1) | WB; IHC; ICC; IP. |
| PAR901Mu01 | Polyclonal Antibody to Catenin Beta Interacting Protein 1 (CTNNbIP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR901Mu01 | CLIA Kit for Catenin Beta Interacting Protein 1 (CTNNbIP1) | CLIA assay for Antigen Detection |
| ELR901Mu01 | ELISA Kit for Catenin Beta Interacting Protein 1 (CTNNbIP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR901Ra01 | Recombinant Catenin Beta Interacting Protein 1 (CTNNbIP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR901Ra01 | Monoclonal Antibody to Catenin Beta Interacting Protein 1 (CTNNbIP1) | WB; IHC; ICC; IP. |
| PAR901Ra01 | Polyclonal Antibody to Catenin Beta Interacting Protein 1 (CTNNbIP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR901Ra01 | CLIA Kit for Catenin Beta Interacting Protein 1 (CTNNbIP1) | CLIA assay for Antigen Detection |
| ELR901Ra01 | ELISA Kit for Catenin Beta Interacting Protein 1 (CTNNbIP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR901Ca01 | Recombinant Catenin Beta Interacting Protein 1 (CTNNbIP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR901Ca01 | Monoclonal Antibody to Catenin Beta Interacting Protein 1 (CTNNbIP1) | WB; IHC; ICC; IP. |
| PAR901Ca01 | Polyclonal Antibody to Catenin Beta Interacting Protein 1 (CTNNbIP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR901Ca01 | CLIA Kit for Catenin Beta Interacting Protein 1 (CTNNbIP1) | CLIA assay for Antigen Detection |
| ELR901Ca01 | ELISA Kit for Catenin Beta Interacting Protein 1 (CTNNbIP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR901Po01 | Recombinant Catenin Beta Interacting Protein 1 (CTNNbIP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR901Po01 | Monoclonal Antibody to Catenin Beta Interacting Protein 1 (CTNNbIP1) | WB; IHC; ICC; IP. |
| PAR901Po01 | Polyclonal Antibody to Catenin Beta Interacting Protein 1 (CTNNbIP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR901Po01 | CLIA Kit for Catenin Beta Interacting Protein 1 (CTNNbIP1) | CLIA assay for Antigen Detection |
| ELR901Po01 | ELISA Kit for Catenin Beta Interacting Protein 1 (CTNNbIP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR901Bo01 | Recombinant Catenin Beta Interacting Protein 1 (CTNNbIP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR901Bo01 | Monoclonal Antibody to Catenin Beta Interacting Protein 1 (CTNNbIP1) | WB; IHC; ICC; IP. |
| PAR901Bo01 | Polyclonal Antibody to Catenin Beta Interacting Protein 1 (CTNNbIP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR901Bo01 | CLIA Kit for Catenin Beta Interacting Protein 1 (CTNNbIP1) | CLIA assay for Antigen Detection |
| ELR901Bo01 | ELISA Kit for Catenin Beta Interacting Protein 1 (CTNNbIP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR901Rb01 | Recombinant Catenin Beta Interacting Protein 1 (CTNNbIP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR901Rb01 | Monoclonal Antibody to Catenin Beta Interacting Protein 1 (CTNNbIP1) | WB; IHC; ICC; IP. |
| PAR901Rb01 | Polyclonal Antibody to Catenin Beta Interacting Protein 1 (CTNNbIP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR901Rb01 | CLIA Kit for Catenin Beta Interacting Protein 1 (CTNNbIP1) | CLIA assay for Antigen Detection |
| ELR901Rb01 | ELISA Kit for Catenin Beta Interacting Protein 1 (CTNNbIP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR901Mo01 | Recombinant Catenin Beta Interacting Protein 1 (CTNNbIP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR901Mo01 | Monoclonal Antibody to Catenin Beta Interacting Protein 1 (CTNNbIP1) | WB; IHC; ICC; IP. |
| PAR901Mo01 | Polyclonal Antibody to Catenin Beta Interacting Protein 1 (CTNNbIP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR901Mo01 | CLIA Kit for Catenin Beta Interacting Protein 1 (CTNNbIP1) | CLIA assay for Antigen Detection |
| ELR901Mo01 | ELISA Kit for Catenin Beta Interacting Protein 1 (CTNNbIP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein."
Genes Dev. 14:1741-1749(2000) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"The crystal structure of the beta-catenin/ICAT complex reveals the inhibitory mechanism of ICAT."
Mol. Cell 10:563-571(2002) [PubMed] [Europe PMC] [Abstract]
"ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules."
Mol. Cell 10:573-584(2002) [PubMed] [Europe PMC] [Abstract]