Eukaryotic Translation Initiation Factor 3M (EIF3M)

PCID1; HFLB5; GA17; eIF3m; hfl-B5; PCI Domain Containing 1; Herpesvirus Entry Mediator; Fetal lung protein B5; PCI domain-containing protein 1

SPN	R806
HGNC	24460
MGI	1351744
PubMed	19483676
RGD	1565840
UniProt	Q7L2H7
Wiki	EIF3M

HFLB5 encodes a broadly expressed protein containing putative membrane fusion domains that acts as a receptor or coreceptor for entry of herpes simplex virus (HSV) The predicted 374-amino acid type II membrane protein contains 2 N-glycosylation sites and a C-terminal heptad repeat that forms a coiled-coil structure. HFLB5 lacks a signal peptide. Microscopic, immunoprecipitation, Western blot, and FACS analyses demonstrated that the HFLB5 C terminus is exposed extracellularly on the cell surface. Northern blot and RT-PCR analyses of human tissues and cell lines revealed broad expression of a 1.3-kb HFLB5 transcript. Entry of HSV into HFLB5-expressing porcine and human cells could be blocked by a 30-mer peptide identical to the HFLB5 C-terminal coiled-coil region.

Reference

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, Submitted (MAR-2008) to UniProtKB

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