Profilin 2 (PFN2)

PFL

SPN	R728
HGNC	8882
MGI	97550
PubMed	22253883
RGD	621826
UniProt	P35080
Wiki	PFN2

Profilin-2 is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought to regulate actin polymerization in response to extracellular signals. There are two alternatively spliced transcript variants encoding different isoforms described for this gene.

Profilin is a 14-kDa protein responsible for keeping the cytoskeletal protein actin monomeric under ionic conditions that promote its polymerization into filaments. Two isoforms of profilin are known: profilin-1 (PFN1) and profilin-2 (PFN2). By expressing both isoforms in E. coli, Gieselmann et al. (1995) assessed the biochemical characteristics of the profilins and compared their interactions with poly(L-proline), phosphatidylinositol-4,5- bisphosphate, and actin.

Reference

"Cloning and expression of a novel human profilin variant, profilin II."
FEBS Lett. 330:151-155(1993) [PubMed] [Europe PMC] [Abstract]

"Profilin II is alternatively spliced, resulting in profilin isoforms that are differentially expressed and have distinct biochemical properties."
Mol. Cell. Biol. 20:8209-8219(2000) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]