Aurora Kinase B (AURKB)

AIM1; AIK2; ARK2; AurB; IPL1; STK1; STK12; STK5; Serine/Threonine Kinase 12; Aurora-1; Aurora-and IPL1-like midbody-associated protein 1; Aurora/IPL1-related kinase 2

SPN	R587
HGNC	11390
MGI	107168
PubMed	11413462
RGD	621625
UniProt	Q96GD4
Wiki	AURKB

Aurora B kinase is a protein that functions in the attachment of the mitotic spindle to the centromere. Chromosomal segregation during mitosis as well as meiosis is regulated by kinases and phosphatases. The Aurora kinases associate with microtubules during chromosome movement and segregation. Aurora kinase B localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers, and Aurora kinase A localizes to centrosomes. In cancerous cells, over-expression of these enzymes causes unequal distribution of genetic information, creating aneuploid cells, a hallmark of cancer.High level expression seen in the thymus. It is also expressed in the spleen, lung, testis, colon, placenta and fetal liver.

Reference

"cDNA cloning, expression, subcellular localization, and chromosomal assignment of mammalian aurora homologues, aurora-related kinase (ARK) 1 and 2."
Biochem. Biophys. Res. Commun. 244:285-292(1998) [PubMed] [Europe PMC] [Abstract]

"Multinuclearity and increased ploidy caused by overexpression of the aurora- and Ipl1-like midbody-associated protein mitotic kinase in human cancer cells."
Cancer Res. 58:4811-4816(1998) [PubMed] [Europe PMC] [Abstract]

"Identification and characterization of STK12/Aik2: a human gene related to aurora of Drosophila and yeast IPL1."
Cytogenet. Cell Genet. 82:147-152(1998) [PubMed] [Europe PMC] [Abstract]

"In silico cloning of a new protein kinase, Aik2, related to Drosophila aurora using the new tool: EST Blast."
In Silico Biol. 1:123-128(1999) [PubMed] [Europe PMC] [Abstract]

"Expression of Aurora B and alternative variant forms in hepatocellular carcinoma and adjacent tissue."
Cancer Sci. 100:472-480(2009) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis."
Curr. Biol. 11:886-890(2001) [PubMed] [Europe PMC] [Abstract]

"CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis."
J. Cell Biol. 155:1147-1157(2001) [PubMed] [Europe PMC] [Abstract]

"Mitotic kinases as regulators of cell division and its checkpoints."
Nat. Rev. Mol. Cell Biol. 2:21-32(2001) [PubMed] [Europe PMC] [Abstract]

"Aurora-B phosphorylates Histone H3 at serine28 with regard to the mitotic chromosome condensation."
Genes Cells 7:11-17(2002) [PubMed] [Europe PMC] [Abstract]

"Mitotic phosphorylation of histone H3: spatio-temporal regulation by mammalian Aurora kinases."
Mol. Cell. Biol. 22:874-885(2002) [PubMed] [Europe PMC] [Abstract]

"Phosphorylation by aurora B converts MgcRacGAP to a RhoGAP during cytokinesis."
Dev. Cell 4:549-560(2003) [PubMed] [Europe PMC] [Abstract]

"Aurora-B regulates the cleavage furrow-specific vimentin phosphorylation in the cytokinetic process."
J. Biol. Chem. 278:8526-8530(2003) [PubMed] [Europe PMC] [Abstract]

"Functional significance of the specific sites phosphorylated in desmin at cleavage furrow: Aurora-B may phosphorylate and regulate type III intermediate filaments during cytokinesis coordinatedly with Rho-kinase."
Mol. Biol. Cell 14:1489-1500(2003) [PubMed] [Europe PMC] [Abstract]

"Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis."
Mol. Biol. Cell 14:3325-3341(2003) [PubMed] [Europe PMC] [Abstract]

"Human Aurora-B binds to a proteasome alpha-subunit HC8 and undergoes degradation in a proteasome-dependent manner."
Mol. Cell. Biochem. 254:157-162(2003) [PubMed] [Europe PMC] [Abstract]

"Aurora-B phosphorylation in vitro identifies a residue of survivin that is essential for its localization and binding to inner centromere protein (INCENP) in vivo."
J. Biol. Chem. 279:5655-5660(2004) [PubMed] [Europe PMC] [Abstract]

"Autophosphorylation of a newly identified site of Aurora-B is indispensable for cytokinesis."
J. Biol. Chem. 279:12997-13003(2004) [PubMed] [Europe PMC] [Abstract]

"Bub1 is required for kinetochore localization of BubR1, Cenp-E, Cenp-F and Mad2, and chromosome congression."
J. Cell Sci. 117:1577-1589(2004) [PubMed] [Europe PMC] [Abstract]

"Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle."
J. Cell Biol. 166:179-191(2004) [PubMed] [Europe PMC] [Abstract]

"Identification of the substrates and interaction proteins of aurora kinases from a protein-protein interaction model."
Mol. Cell. Proteomics 3:93-104(2004) [PubMed] [Europe PMC] [Abstract]

"Aurora B -TACC1 protein complex in cytokinesis."
Oncogene 23:4516-4522(2004) [PubMed] [Europe PMC] [Abstract]

"Septin1, a new interaction partner for human serine/threonine kinase aurora-B."
Biochem. Biophys. Res. Commun. 336:994-1000(2005) [PubMed] [Europe PMC] [Abstract]

"An ECT2-centralspindlin complex regulates the localization and function of RhoA."
J. Cell Biol. 170:571-582(2005) [PubMed] [Europe PMC] [Abstract]

"EVI5 protein associates with the INCENP-aurora B kinase-survivin chromosomal passenger complex and is involved in the completion of cytokinesis."
Exp. Cell Res. 312:2325-2335(2006) [PubMed] [Europe PMC] [Abstract]

"Shugoshin 1 plays a central role in kinetochore assembly and is required for kinetochore targeting of Plk1."
Cell Cycle 6:1579-1585(2007) [PubMed] [Europe PMC] [Abstract]

"A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cells."
Dev. Cell 12:887-900(2007) [PubMed] [Europe PMC] [Abstract]

"Interphase nucleo-cytoplasmic shuttling and localization of SIRT2 during mitosis."
PLoS ONE 2:E784-E784(2007) [PubMed] [Europe PMC] [Abstract]

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

"A survivin-ran complex regulates spindle formation in tumor cells."
Mol. Cell. Biol. 28:5299-5311(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis."
J. Cell Biol. 187:791-800(2009) [PubMed] [Europe PMC] [Abstract]

"Large-scale proteomics analysis of the human kinome."
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

"RINGO C is required to sustain the spindle-assembly checkpoint."
J. Cell Sci. 123:2586-2595(2010) [PubMed] [Europe PMC] [Abstract]

"Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation."
Nat. Cell Biol. 12:719-727(2010) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"A positive feedback loop involving Haspin and Aurora B promotes CPC accumulation at centromeres in mitosis."
Curr. Biol. 21:1061-1069(2011) [PubMed] [Europe PMC] [Abstract]

"Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression."
J. Biol. Chem. 286:2236-2244(2011) [PubMed] [Europe PMC] [Abstract]

"PAR, a protein involved in the cell cycle, is functionally related to chromosomal passenger proteins."
Int. J. Oncol. 38:777-785(2011) [PubMed] [Europe PMC] [Abstract]

"A novel big protein TPRBK possessing 25 units of TPR motif is essential for the progress of mitosis and cytokinesis."
Gene 511:202-217(2012) [PubMed] [Europe PMC] [Abstract]

"ESCRT-III governs the Aurora B-mediated abscission checkpoint through CHMP4C."
Science 336:220-225(2012) [PubMed] [Europe PMC] [Abstract]

"ANCHR mediates Aurora-B-dependent abscission checkpoint control through retention of VPS4."
Nat. Cell Biol. 16:550-560(2014) [PubMed] [Europe PMC] [Abstract]

"Aurora kinases A and B and familial breast cancer risk."
Cancer Lett. 247:266-272(2007) [PubMed] [Europe PMC] [Abstract]

"Patterns of somatic mutation in human cancer genomes."
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]