Claudin 16 (CLDN16)

PCLN1; HOMG3; Paracellin-1; Hypomagnesemia 3,With Hypercalciuria And Nephrocalcinosis

SPN	R502
HGNC	2037
MGI	2148742
PubMed	22422540
RGD	620322
UniProt	Q9Y5I7
Wiki	CLDN16

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are composed of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet.

CLDN16, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is found primarily in the kidneys, specifically in the thick ascending limb of Henle, where it acts as either an intercellular pore or ion concentration sensor to regulate the paracellular resorption of magnesium ions.

Reference

"Paracellin-1, a renal tight junction protein required for paracellular Mg2+ resorption."
Science 285:103-106(1999) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Familial hypomagnesaemia with hypercalciuria and nephrocalcinosis maps to chromosome 3q27 and is associated with mutations in the PCLN-1 gene."
Eur. J. Hum. Genet. 8:414-422(2000) [PubMed] [Europe PMC] [Abstract]

"Novel paracellin-1 mutations in 25 families with familial hypomagnesemia with hypercalciuria and nephrocalcinosis."
J. Am. Soc. Nephrol. 12:1872-1881(2001) [PubMed] [Europe PMC] [Abstract]