YY1 Transcription Factor (YY1)

NF-E1; DELTA; UCRBP; YIN-YANG-1; INO80S; INO80 Complex Subunit S; Yin and Yang 1 Protein; Delta transcription factor; INO80 complex subunit S

SPN	R222
HGNC	12856
MGI	99150
PubMed	24821761
RGD	3982
UniProt	P25490
Wiki	YY1

YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1.

Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. May play an important role in development and differentiation. The function of YY1 as an activator or a repressor is specified by the presence of other proteins.

Reference

"Transcriptional repression by YY1, a human GLI-Kruppel-related protein, and relief of repression by adenovirus E1A protein."
Cell 67:377-388(1991) [PubMed] [Europe PMC] [Abstract]

"Isolation of a candidate repressor/activator, NF-E1 (YY-1, delta), that binds to the immunoglobulin kappa 3' enhancer and the immunoglobulin heavy-chain mu E1 site."
Proc. Natl. Acad. Sci. U.S.A. 88:9804-9808(1991) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Targeting of the YY1 transcription factor to the nucleolus and the nuclear matrix in situ: the C-terminus is a principal determinant for nuclear trafficking."
J. Cell. Biochem. 68:500-510(1998) [PubMed] [Europe PMC] [Abstract]

"Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1."
Nucleic Acids Res. 25:843-849(1997) [PubMed] [Europe PMC] [Abstract]

"Poly(ADP-ribosyl)ation of transcription factor Yin Yang 1 under conditions of DNA damage."
Biochem. Biophys. Res. Commun. 285:27-31(2001) [PubMed] [Europe PMC] [Abstract]

"The polycomb group protein EED interacts with YY1, and both proteins induce neural tissue in Xenopus embryos."
Mol. Cell. Biol. 21:1360-1369(2001) [PubMed] [Europe PMC] [Abstract]

"SMAD-mediated modulation of YY1 activity regulates the BMP response and cardiac-specific expression of a GATA4/5/6-dependent chick Nkx2.5 enhancer."
Development 131:4709-4723(2004) [PubMed] [Europe PMC] [Abstract]

"Transcription factor YY1: structure, function, and therapeutic implications in cancer biology."
Oncogene 25:1125-1142(2006) [PubMed] [Europe PMC] [Abstract]

"YY1 functions with INO80 to activate transcription."
Nat. Struct. Mol. Biol. 14:872-874(2007) [PubMed] [Europe PMC] [Abstract]

"A YY1-INO80 complex regulates genomic stability through homologous recombination-based repair."
Nat. Struct. Mol. Biol. 14:1165-1172(2007) [PubMed] [Europe PMC] [Abstract]

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

"Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex."
Mol. Cell 31:909-917(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"YY1's longer DNA-binding motifs."
Genomics 93:152-158(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Development and validation of a method for profiling post-translational modification activities using protein microarrays."
PLoS ONE 5:E11332-E11332(2010) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Subunit organization of the human INO80 chromatin remodeling complex: An evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling."
J. Biol. Chem. 286:11283-11289(2011) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"Regulation of DU145 prostate cancer cell growth by Scm-like with four mbt domains 2."
J. Biosci. 38:105-112(2013) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Cocrystal structure of YY1 bound to the adeno-associated virus P5 initiator."
Proc. Natl. Acad. Sci. U.S.A. 93:13577-13582(1996) [PubMed] [Europe PMC] [Abstract]

"Design, synthesis and structure of a zinc finger with an artificial beta-turn."
J. Mol. Biol. 279:973-986(1998) [PubMed] [Europe PMC] [Abstract]

"A de novo paradigm for mental retardation."
Nat. Genet. 42:1109-1112(2010) [PubMed] [Europe PMC] [Abstract]