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S-Phase Kinase Associated Protein 1 (SKP1)

SKP1A; EMC19; OCP-II; OCP2; TCEB1L; p19A; Cyclin-A/CDK2-associated p19; RNA polymerase II elongation factor-like protein; Transcription elongation factor B polypeptide 1-like

S-phase kinase-associated protein 1 is a member of the SCF ubiquitin ligase protein complex. It binds to proteins containing an F-box motif, such as cyclin F, S-phase kinase-associated protein 2, and other regulatory proteins involved in ubiquitin dependent proteolysis.
The encoded protein also collaborates with a network of proteins to control beta-catenin levels and affects the activity level of beta-catenin dependent TCF transcription factors. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ923Hu01 Recombinant S-Phase Kinase Associated Protein 1 (SKP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ923Hu01 Monoclonal Antibody to S-Phase Kinase Associated Protein 1 (SKP1) WB; IHC; ICC; IP.
PAQ923Hu01 Polyclonal Antibody to S-Phase Kinase Associated Protein 1 (SKP1) WB; IHC; ICC; IF.
Assay Kits CLQ923Hu01 CLIA Kit for S-Phase Kinase Associated Protein 1 (SKP1) CLIA assay for Antigen Detection
ELQ923Hu01 ELISA Kit for S-Phase Kinase Associated Protein 1 (SKP1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ923Mu01 Recombinant S-Phase Kinase Associated Protein 1 (SKP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ923Mu01 Monoclonal Antibody to S-Phase Kinase Associated Protein 1 (SKP1) WB; IHC; ICC; IP.
PAQ923Mu01 Polyclonal Antibody to S-Phase Kinase Associated Protein 1 (SKP1) WB; IHC; ICC; IF.
Assay Kits CLQ923Mu01 CLIA Kit for S-Phase Kinase Associated Protein 1 (SKP1) CLIA assay for Antigen Detection
ELQ923Mu01 ELISA Kit for S-Phase Kinase Associated Protein 1 (SKP1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ923Ra01 Recombinant S-Phase Kinase Associated Protein 1 (SKP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ923Ra01 Monoclonal Antibody to S-Phase Kinase Associated Protein 1 (SKP1) WB; IHC; ICC; IP.
PAQ923Ra01 Polyclonal Antibody to S-Phase Kinase Associated Protein 1 (SKP1) WB; IHC; ICC; IF.
Assay Kits CLQ923Ra01 CLIA Kit for S-Phase Kinase Associated Protein 1 (SKP1) CLIA assay for Antigen Detection
ELQ923Ra01 ELISA Kit for S-Phase Kinase Associated Protein 1 (SKP1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ923Ca01 Recombinant S-Phase Kinase Associated Protein 1 (SKP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ923Ca01 Monoclonal Antibody to S-Phase Kinase Associated Protein 1 (SKP1) WB; IHC; ICC; IP.
PAQ923Ca01 Polyclonal Antibody to S-Phase Kinase Associated Protein 1 (SKP1) WB; IHC; ICC; IF.
Assay Kits CLQ923Ca01 CLIA Kit for S-Phase Kinase Associated Protein 1 (SKP1) CLIA assay for Antigen Detection
ELQ923Ca01 ELISA Kit for S-Phase Kinase Associated Protein 1 (SKP1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ923Po01 Recombinant S-Phase Kinase Associated Protein 1 (SKP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ923Po01 Monoclonal Antibody to S-Phase Kinase Associated Protein 1 (SKP1) WB; IHC; ICC; IP.
PAQ923Po01 Polyclonal Antibody to S-Phase Kinase Associated Protein 1 (SKP1) WB; IHC; ICC; IF.
Assay Kits CLQ923Po01 CLIA Kit for S-Phase Kinase Associated Protein 1 (SKP1) CLIA assay for Antigen Detection
ELQ923Po01 ELISA Kit for S-Phase Kinase Associated Protein 1 (SKP1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ923Bo01 Recombinant S-Phase Kinase Associated Protein 1 (SKP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ923Bo01 Monoclonal Antibody to S-Phase Kinase Associated Protein 1 (SKP1) WB; IHC; ICC; IP.
PAQ923Bo01 Polyclonal Antibody to S-Phase Kinase Associated Protein 1 (SKP1) WB; IHC; ICC; IF.
Assay Kits CLQ923Bo01 CLIA Kit for S-Phase Kinase Associated Protein 1 (SKP1) CLIA assay for Antigen Detection
ELQ923Bo01 ELISA Kit for S-Phase Kinase Associated Protein 1 (SKP1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ923Rb01 Recombinant S-Phase Kinase Associated Protein 1 (SKP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ923Rb01 Monoclonal Antibody to S-Phase Kinase Associated Protein 1 (SKP1) WB; IHC; ICC; IP.
PAQ923Rb01 Polyclonal Antibody to S-Phase Kinase Associated Protein 1 (SKP1) WB; IHC; ICC; IF.
Assay Kits CLQ923Rb01 CLIA Kit for S-Phase Kinase Associated Protein 1 (SKP1) CLIA assay for Antigen Detection
ELQ923Rb01 ELISA Kit for S-Phase Kinase Associated Protein 1 (SKP1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ923Mo01 Recombinant S-Phase Kinase Associated Protein 1 (SKP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ923Mo01 Monoclonal Antibody to S-Phase Kinase Associated Protein 1 (SKP1) WB; IHC; ICC; IP.
PAQ923Mo01 Polyclonal Antibody to S-Phase Kinase Associated Protein 1 (SKP1) WB; IHC; ICC; IF.
Assay Kits CLQ923Mo01 CLIA Kit for S-Phase Kinase Associated Protein 1 (SKP1) CLIA assay for Antigen Detection
ELQ923Mo01 ELISA Kit for S-Phase Kinase Associated Protein 1 (SKP1) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

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"A novel cDNA with homology to an RNA polymerase II elongation factors maps to human chromosome 5q31 (TCEB1L) and to mouse chromosome 11 (Tceb1l)."
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"Human inner ear OCP2 cDNA maps to 5q22-5q35.2 with related sequences on chromosomes 4p16.2-4p14, 5p13-5q22, 7pter-q22, 10 and 12p13-12qter."
Gene 184:163-167(1997) [PubMed] [Europe PMC] [Abstract]

"CUL7: a DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex."
Proc. Natl. Acad. Sci. U.S.A. 99:16601-16606(2002) [PubMed] [Europe PMC] [Abstract]

"Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses."
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"SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation."
Nature 466:138-142(2010) [PubMed] [Europe PMC] [Abstract]

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Nature 481:90-93(2012) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

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Nature 408:381-386(2000) [PubMed] [Europe PMC] [Abstract]

"Structure of the Cul1-Rbx1-Skp1-F box Skp2 SCF ubiquitin ligase complex."
Nature 416:703-709(2002) [PubMed] [Europe PMC] [Abstract]

"Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase."
Mol. Cell 11:1445-1456(2003) [PubMed] [Europe PMC] [Abstract]

"Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase."
Mol. Cell 20:9-19(2005) [PubMed] [Europe PMC] [Abstract]

"Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases."
Mol. Cell 26:131-143(2007) [PubMed] [Europe PMC] [Abstract]

"Structural basis for the selection of glycosylated substrates by SCF(Fbs1) ubiquitin ligase."
Proc. Natl. Acad. Sci. U.S.A. 104:5777-5781(2007) [PubMed] [Europe PMC] [Abstract]

"Structural basis of dimerization-dependent ubiquitination by the SCF(Fbx4) ubiquitin ligase."
J. Biol. Chem. 285:13896-13906(2010) [PubMed] [Europe PMC] [Abstract]