Proteasome 26S Subunit, Non ATPase 2 (PSMD2)

P97; S2; TRAP2; Rpn1; Tumor necrosis factor type 1 receptor-associated protein 2; 26S proteasome regulatory subunit RPN1; 26S proteasome subunit p97

SPN	Q535
HGNC	9559
MGI	1096584
PubMed	17949559
RGD	1305752
UniProt	Q13200
Wiki	PSMD2

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits.

PSMD2 encodes one of the non-ATPase subunits of the 19S regulator lid. In addition to participation in proteasome function, this subunit may also participate in the TNF signalling pathway since it interacts with the tumor necrosis factor type 1 receptor. A pseudogene has been identified on chromosome 1.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ535Hu01	Recombinant Proteasome 26S Subunit, Non ATPase 2 (PSMD2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ535Hu01	Monoclonal Antibody to Proteasome 26S Subunit, Non ATPase 2 (PSMD2)	WB; IHC; ICC; IP.
Antibodies	PAQ535Hu01	Polyclonal Antibody to Proteasome 26S Subunit, Non ATPase 2 (PSMD2)	WB; IHC; ICC; IF.
Assay Kits	CLQ535Hu01	CLIA Kit for Proteasome 26S Subunit, Non ATPase 2 (PSMD2)	CLIA assay for Antigen Detection
Assay Kits	ELQ535Hu01	ELISA Kit for Proteasome 26S Subunit, Non ATPase 2 (PSMD2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ535Mu01	Recombinant Proteasome 26S Subunit, Non ATPase 2 (PSMD2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ535Mu01	Monoclonal Antibody to Proteasome 26S Subunit, Non ATPase 2 (PSMD2)	WB; IHC; ICC; IP.
Antibodies	PAQ535Mu01	Polyclonal Antibody to Proteasome 26S Subunit, Non ATPase 2 (PSMD2)	WB; IHC; ICC; IF.
Assay Kits	CLQ535Mu01	CLIA Kit for Proteasome 26S Subunit, Non ATPase 2 (PSMD2)	CLIA assay for Antigen Detection
Assay Kits	ELQ535Mu01	ELISA Kit for Proteasome 26S Subunit, Non ATPase 2 (PSMD2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ535Ra01	Recombinant Proteasome 26S Subunit, Non ATPase 2 (PSMD2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ535Ra01	Monoclonal Antibody to Proteasome 26S Subunit, Non ATPase 2 (PSMD2)	WB; IHC; ICC; IP.
Antibodies	PAQ535Ra01	Polyclonal Antibody to Proteasome 26S Subunit, Non ATPase 2 (PSMD2)	WB; IHC; ICC; IF.
Assay Kits	CLQ535Ra01	CLIA Kit for Proteasome 26S Subunit, Non ATPase 2 (PSMD2)	CLIA assay for Antigen Detection
Assay Kits	ELQ535Ra01	ELISA Kit for Proteasome 26S Subunit, Non ATPase 2 (PSMD2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ535Ca01	Recombinant Proteasome 26S Subunit, Non ATPase 2 (PSMD2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ535Ca01	Monoclonal Antibody to Proteasome 26S Subunit, Non ATPase 2 (PSMD2)	WB; IHC; ICC; IP.
Antibodies	PAQ535Ca01	Polyclonal Antibody to Proteasome 26S Subunit, Non ATPase 2 (PSMD2)	WB; IHC; ICC; IF.
Assay Kits	CLQ535Ca01	CLIA Kit for Proteasome 26S Subunit, Non ATPase 2 (PSMD2)	CLIA assay for Antigen Detection
Assay Kits	ELQ535Ca01	ELISA Kit for Proteasome 26S Subunit, Non ATPase 2 (PSMD2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ535Po01	Recombinant Proteasome 26S Subunit, Non ATPase 2 (PSMD2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ535Po01	Monoclonal Antibody to Proteasome 26S Subunit, Non ATPase 2 (PSMD2)	WB; IHC; ICC; IP.
Antibodies	PAQ535Po01	Polyclonal Antibody to Proteasome 26S Subunit, Non ATPase 2 (PSMD2)	WB; IHC; ICC; IF.
Assay Kits	CLQ535Po01	CLIA Kit for Proteasome 26S Subunit, Non ATPase 2 (PSMD2)	CLIA assay for Antigen Detection
Assay Kits	ELQ535Po01	ELISA Kit for Proteasome 26S Subunit, Non ATPase 2 (PSMD2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ535Bo01	Recombinant Proteasome 26S Subunit, Non ATPase 2 (PSMD2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ535Bo01	Monoclonal Antibody to Proteasome 26S Subunit, Non ATPase 2 (PSMD2)	WB; IHC; ICC; IP.
Antibodies	PAQ535Bo01	Polyclonal Antibody to Proteasome 26S Subunit, Non ATPase 2 (PSMD2)	WB; IHC; ICC; IF.
Assay Kits	CLQ535Bo01	CLIA Kit for Proteasome 26S Subunit, Non ATPase 2 (PSMD2)	CLIA assay for Antigen Detection
Assay Kits	ELQ535Bo01	ELISA Kit for Proteasome 26S Subunit, Non ATPase 2 (PSMD2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ535Rb01	Recombinant Proteasome 26S Subunit, Non ATPase 2 (PSMD2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ535Rb01	Monoclonal Antibody to Proteasome 26S Subunit, Non ATPase 2 (PSMD2)	WB; IHC; ICC; IP.
Antibodies	PAQ535Rb01	Polyclonal Antibody to Proteasome 26S Subunit, Non ATPase 2 (PSMD2)	WB; IHC; ICC; IF.
Assay Kits	CLQ535Rb01	CLIA Kit for Proteasome 26S Subunit, Non ATPase 2 (PSMD2)	CLIA assay for Antigen Detection
Assay Kits	ELQ535Rb01	ELISA Kit for Proteasome 26S Subunit, Non ATPase 2 (PSMD2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ535Mo01	Recombinant Proteasome 26S Subunit, Non ATPase 2 (PSMD2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ535Mo01	Monoclonal Antibody to Proteasome 26S Subunit, Non ATPase 2 (PSMD2)	WB; IHC; ICC; IP.
Antibodies	PAQ535Mo01	Polyclonal Antibody to Proteasome 26S Subunit, Non ATPase 2 (PSMD2)	WB; IHC; ICC; IF.
Assay Kits	CLQ535Mo01	CLIA Kit for Proteasome 26S Subunit, Non ATPase 2 (PSMD2)	CLIA assay for Antigen Detection
Assay Kits	ELQ535Mo01	ELISA Kit for Proteasome 26S Subunit, Non ATPase 2 (PSMD2)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"cDNA cloning and functional analysis of the p97 subunit of the 26S proteasome, a polypeptide identical to the type-1 tumor-necrosis-factor-receptor-associated protein-2/55.11."
Eur. J. Biochem. 239:912-921(1996) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence, annotation and analysis of human chromosome 3."
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Two-hybrid cloning of a gene encoding TNF receptor-associated protein 2, a protein that interacts with the intracellular domain of the type 1 TNF receptor: identity with subunit 2 of the 26S protease."
J. Immunol. 158:4252-4259(1997) [PubMed] [Europe PMC] [Abstract]

"A protein related to a proteasomal subunit binds to the intracellular domain of the p55 TNF receptor upstream to its 'death domain'."
FEBS Lett. 367:39-44(1995) [PubMed] [Europe PMC] [Abstract]

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

"Mass spectrometric characterization of the affinity-purified human 26S proteasome complex."
Biochemistry 46:3553-3565(2007) [PubMed] [Europe PMC] [Abstract]

"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."
J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]