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Proteasome 26S Subunit, Non ATPase 4 (PSMD4)

ASF; AF-1; AF; MCB1; Rpn10; S5A; pUB-R5; Antisecretory factor 1; Multiubiquitin chain-binding protein; 26S proteasome regulatory subunit RPN10

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. PSMD4 encodes one of the non-ATPase subunits of the 19S regulator lid. Pseudogenes have been identified on chromosomes 10 and 21.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ534Hu01 Recombinant Proteasome 26S Subunit, Non ATPase 4 (PSMD4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ534Hu01 Monoclonal Antibody to Proteasome 26S Subunit, Non ATPase 4 (PSMD4) WB; IHC; ICC; IP.
PAQ534Hu01 Polyclonal Antibody to Proteasome 26S Subunit, Non ATPase 4 (PSMD4) WB; IHC; ICC; IF.
Assay Kits CLQ534Hu01 CLIA Kit for Proteasome 26S Subunit, Non ATPase 4 (PSMD4) CLIA assay for Antigen Detection
ELQ534Hu01 ELISA Kit for Proteasome 26S Subunit, Non ATPase 4 (PSMD4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ534Mu01 Recombinant Proteasome 26S Subunit, Non ATPase 4 (PSMD4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ534Mu01 Monoclonal Antibody to Proteasome 26S Subunit, Non ATPase 4 (PSMD4) WB; IHC; ICC; IP.
PAQ534Mu01 Polyclonal Antibody to Proteasome 26S Subunit, Non ATPase 4 (PSMD4) WB; IHC; ICC; IF.
Assay Kits CLQ534Mu01 CLIA Kit for Proteasome 26S Subunit, Non ATPase 4 (PSMD4) CLIA assay for Antigen Detection
ELQ534Mu01 ELISA Kit for Proteasome 26S Subunit, Non ATPase 4 (PSMD4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ534Ra01 Recombinant Proteasome 26S Subunit, Non ATPase 4 (PSMD4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ534Ra01 Monoclonal Antibody to Proteasome 26S Subunit, Non ATPase 4 (PSMD4) WB; IHC; ICC; IP.
PAQ534Ra01 Polyclonal Antibody to Proteasome 26S Subunit, Non ATPase 4 (PSMD4) WB; IHC; ICC; IF.
Assay Kits CLQ534Ra01 CLIA Kit for Proteasome 26S Subunit, Non ATPase 4 (PSMD4) CLIA assay for Antigen Detection
ELQ534Ra01 ELISA Kit for Proteasome 26S Subunit, Non ATPase 4 (PSMD4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ534Ca01 Recombinant Proteasome 26S Subunit, Non ATPase 4 (PSMD4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ534Ca01 Monoclonal Antibody to Proteasome 26S Subunit, Non ATPase 4 (PSMD4) WB; IHC; ICC; IP.
PAQ534Ca01 Polyclonal Antibody to Proteasome 26S Subunit, Non ATPase 4 (PSMD4) WB; IHC; ICC; IF.
Assay Kits CLQ534Ca01 CLIA Kit for Proteasome 26S Subunit, Non ATPase 4 (PSMD4) CLIA assay for Antigen Detection
ELQ534Ca01 ELISA Kit for Proteasome 26S Subunit, Non ATPase 4 (PSMD4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ534Po01 Recombinant Proteasome 26S Subunit, Non ATPase 4 (PSMD4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ534Po01 Monoclonal Antibody to Proteasome 26S Subunit, Non ATPase 4 (PSMD4) WB; IHC; ICC; IP.
PAQ534Po01 Polyclonal Antibody to Proteasome 26S Subunit, Non ATPase 4 (PSMD4) WB; IHC; ICC; IF.
Assay Kits CLQ534Po01 CLIA Kit for Proteasome 26S Subunit, Non ATPase 4 (PSMD4) CLIA assay for Antigen Detection
ELQ534Po01 ELISA Kit for Proteasome 26S Subunit, Non ATPase 4 (PSMD4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ534Bo01 Recombinant Proteasome 26S Subunit, Non ATPase 4 (PSMD4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ534Bo01 Monoclonal Antibody to Proteasome 26S Subunit, Non ATPase 4 (PSMD4) WB; IHC; ICC; IP.
PAQ534Bo01 Polyclonal Antibody to Proteasome 26S Subunit, Non ATPase 4 (PSMD4) WB; IHC; ICC; IF.
Assay Kits CLQ534Bo01 CLIA Kit for Proteasome 26S Subunit, Non ATPase 4 (PSMD4) CLIA assay for Antigen Detection
ELQ534Bo01 ELISA Kit for Proteasome 26S Subunit, Non ATPase 4 (PSMD4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ534Rb01 Recombinant Proteasome 26S Subunit, Non ATPase 4 (PSMD4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ534Rb01 Monoclonal Antibody to Proteasome 26S Subunit, Non ATPase 4 (PSMD4) WB; IHC; ICC; IP.
PAQ534Rb01 Polyclonal Antibody to Proteasome 26S Subunit, Non ATPase 4 (PSMD4) WB; IHC; ICC; IF.
Assay Kits CLQ534Rb01 CLIA Kit for Proteasome 26S Subunit, Non ATPase 4 (PSMD4) CLIA assay for Antigen Detection
ELQ534Rb01 ELISA Kit for Proteasome 26S Subunit, Non ATPase 4 (PSMD4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ534Mo01 Recombinant Proteasome 26S Subunit, Non ATPase 4 (PSMD4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ534Mo01 Monoclonal Antibody to Proteasome 26S Subunit, Non ATPase 4 (PSMD4) WB; IHC; ICC; IP.
PAQ534Mo01 Polyclonal Antibody to Proteasome 26S Subunit, Non ATPase 4 (PSMD4) WB; IHC; ICC; IF.
Assay Kits CLQ534Mo01 CLIA Kit for Proteasome 26S Subunit, Non ATPase 4 (PSMD4) CLIA assay for Antigen Detection
ELQ534Mo01 ELISA Kit for Proteasome 26S Subunit, Non ATPase 4 (PSMD4) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Molecular cloning and expression of a pituitary gland protein modulating intestinal fluid secretion."
J. Biol. Chem. 270:20615-20620(1995) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning and expression of a multiubiquitin chain binding subunit of the human 26S protease."
FEBS Lett. 381:143-148(1996) [PubMed] [Europe PMC] [Abstract]

"Developmentally regulated, alternative splicing of the Rpn10 gene generates multiple forms of 26S proteasomes."
EMBO J. 19:4144-4153(2000) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Purification and characterization of the antisecretory factor: a protein in the central nervous system and in the gut which inhibits intestinal hypersecretion induced by cholera toxin."
Biochim. Biophys. Acta 883:138-144(1986) [PubMed] [Europe PMC] [Abstract]

"Characterization of two polyubiquitin binding sites in the 26 S protease subunit 5a."
J. Biol. Chem. 273:5461-5467(1998) [PubMed] [Europe PMC] [Abstract]

"Targeting of NEDD8 and its conjugates for proteasomal degradation by NUB1."
J. Biol. Chem. 276:46655-46660(2001) [PubMed] [Europe PMC] [Abstract]

"An unappreciated role for RNA surveillance."
Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]

"The effects of the polyglutamine repeat protein ataxin-1 on the UbL-UBA protein A1Up."
J. Biol. Chem. 279:42290-42301(2004) [PubMed] [Europe PMC] [Abstract]

"Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation."
Mol. Cell. Biol. 24:8055-8068(2004) [PubMed] [Europe PMC] [Abstract]

"Mass spectrometric characterization of the affinity-purified human 26S proteasome complex."
Biochemistry 46:3553-3565(2007) [PubMed] [Europe PMC] [Abstract]

"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"Identification and proteomic analysis of distinct UBE3A/E6AP protein complexes."
Mol. Cell. Biol. 32:3095-3106(2012) [PubMed] [Europe PMC] [Abstract]

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Structural determinants for the binding of ubiquitin-like domains to the proteasome."
EMBO J. 22:4634-4645(2003) [PubMed] [Europe PMC] [Abstract]

"Structure of the ubiquitin-interacting motif of S5a bound to the ubiquitin-like domain of HR23B."
J. Biol. Chem. 279:4760-4767(2004) [PubMed] [Europe PMC] [Abstract]