ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2)

ATP2B; DAR; SERCA2; Calcium pump 2; Endoplasmic reticulum class 1/2 Ca(2+) ATPase; Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle

SPN	Q437
HGNC	812
MGI	88110
PubMed	11244492
RGD	2174
UniProt	P16615
Wiki	ATP2A2

ATP2A2 is one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms. Isoform SERCA2A is highly expressed in heart and slow twitch skeletal muscle. Isoform SERCA2B is widely expressed, in smooth muscle and nonmuscle tissues such as in adult skin epidermis.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ437Hu01	Recombinant ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ437Hu01	Monoclonal Antibody to ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2)	WB; IHC; ICC; IP.
Antibodies	PAQ437Hu01	Polyclonal Antibody to ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2)	WB; IHC; ICC; IF.
Assay Kits	CLQ437Hu01	CLIA Kit for ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2)	CLIA assay for Antigen Detection
Assay Kits	ELQ437Hu01	ELISA Kit for ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ437Mu01	Recombinant ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ437Mu01	Monoclonal Antibody to ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2)	WB; IHC; ICC; IP.
Antibodies	PAQ437Mu01	Polyclonal Antibody to ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2)	WB; IHC; ICC; IF.
Assay Kits	CLQ437Mu01	CLIA Kit for ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2)	CLIA assay for Antigen Detection
Assay Kits	ELQ437Mu01	ELISA Kit for ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ437Ra01	Recombinant ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ437Ra01	Monoclonal Antibody to ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2)	WB; IHC; ICC; IP.
Antibodies	PAQ437Ra01	Polyclonal Antibody to ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2)	WB; IHC; ICC; IF.
Assay Kits	CLQ437Ra01	CLIA Kit for ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2)	CLIA assay for Antigen Detection
Assay Kits	ELQ437Ra01	ELISA Kit for ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ437Ca01	Recombinant ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ437Ca01	Monoclonal Antibody to ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2)	WB; IHC; ICC; IP.
Antibodies	PAQ437Ca01	Polyclonal Antibody to ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2)	WB; IHC; ICC; IF.
Assay Kits	CLQ437Ca01	CLIA Kit for ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2)	CLIA assay for Antigen Detection
Assay Kits	ELQ437Ca01	ELISA Kit for ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ437Po01	Recombinant ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ437Po01	Monoclonal Antibody to ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2)	WB; IHC; ICC; IP.
Antibodies	PAQ437Po01	Polyclonal Antibody to ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2)	WB; IHC; ICC; IF.
Assay Kits	CLQ437Po01	CLIA Kit for ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2)	CLIA assay for Antigen Detection
Assay Kits	ELQ437Po01	ELISA Kit for ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ437Bo01	Recombinant ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ437Bo01	Monoclonal Antibody to ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2)	WB; IHC; ICC; IP.
Antibodies	PAQ437Bo01	Polyclonal Antibody to ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2)	WB; IHC; ICC; IF.
Assay Kits	CLQ437Bo01	CLIA Kit for ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2)	CLIA assay for Antigen Detection
Assay Kits	ELQ437Bo01	ELISA Kit for ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ437Rb01	Recombinant ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ437Rb01	Monoclonal Antibody to ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2)	WB; IHC; ICC; IP.
Antibodies	PAQ437Rb01	Polyclonal Antibody to ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2)	WB; IHC; ICC; IF.
Assay Kits	CLQ437Rb01	CLIA Kit for ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2)	CLIA assay for Antigen Detection
Assay Kits	ELQ437Rb01	ELISA Kit for ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ437Mo01	Recombinant ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ437Mo01	Monoclonal Antibody to ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2)	WB; IHC; ICC; IP.
Antibodies	PAQ437Mo01	Polyclonal Antibody to ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2)	WB; IHC; ICC; IF.
Assay Kits	CLQ437Mo01	CLIA Kit for ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2)	CLIA assay for Antigen Detection
Assay Kits	ELQ437Mo01	ELISA Kit for ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Molecular cloning of cDNAs from human kidney coding for two alternatively spliced products of the cardiac Ca2+-ATPase gene."
J. Biol. Chem. 263:15024-15031(1988) [PubMed] [Europe PMC] [Abstract]

"The finished DNA sequence of human chromosome 12."
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Identification of a new SERCA2 splice variant regulated during monocytic differentiation."
Biochem. Biophys. Res. Commun. 303:676-684(2003) [PubMed] [Europe PMC] [Abstract]

"TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis."
Mol. Cell. Biol. 24:1758-1768(2004) [PubMed] [Europe PMC] [Abstract]

"Detection of sequence-specific tyrosine nitration of manganese SOD and SERCA in cardiovascular disease and aging."
Am. J. Physiol. 290:H2220-H2227(2006) [PubMed] [Europe PMC] [Abstract]

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"The anti-apoptotic protein HAX-1 interacts with SERCA2 and regulates its protein levels to promote cell survival."
Mol. Biol. Cell 20:306-318(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"POST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transporters."
Proc. Natl. Acad. Sci. U.S.A. 108:19234-19239(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Spectrum of novel ATP2A2 mutations in patients with Darier's disease."
Hum. Mol. Genet. 8:1611-1619(1999) [PubMed] [Europe PMC] [Abstract]

"ATP2A2 mutations in Darier's disease: variant cutaneous phenotypes are associated with missense mutations, but neuropsychiatric features are independent of mutation class."
Hum. Mol. Genet. 8:1621-1630(1999) [PubMed] [Europe PMC] [Abstract]

"ATP2A2 mutations in Darier's disease and their relationship to neuropsychiatric phenotypes."
Hum. Mol. Genet. 8:1631-1636(1999) [PubMed] [Europe PMC] [Abstract]

"Mutations in ATP2A2, encoding a Ca2+ pump, cause Darier disease."
Nat. Genet. 21:271-277(1999) [PubMed] [Europe PMC] [Abstract]

"Acrokeratosis verruciformis of Hopf is caused by mutation in ATP2A2: evidence that it is allelic to Darier's disease."
J. Invest. Dermatol. 120:229-232(2003) [PubMed] [Europe PMC] [Abstract]

"Ca2+-ATPases in non-failing and failing heart: evidence for a novel cardiac sarco/endoplasmic reticulum Ca2+-ATPase 2 isoform (SERCA2c)."
Biochem. J. 395:249-258(2006) [PubMed] [Europe PMC] [Abstract]

"Three-base deletion mutation c.120_122delGTT in ATP2A2 leads to the unique phenotype of comedonal Darier disease."
Br. J. Dermatol. 162:687-689(2010) [PubMed] [Europe PMC] [Abstract]