TNF Receptor Associated Factor 5 (TRAF5)

RNF84; RING finger protein 84

SPN	P994
HGNC	12035
MGI	107548
PubMed	20651286
UniProt	O00463
Wiki	TRAF5

Tumor necrosis factor (TNF) receptor-associated factors (TRAFs), such as TRAF5, are signal transducers for members of the TNF receptor superfamily . TRAF proteins are composed of an N-terminal cysteine/histidine-rich region containing zinc RING and/or zinc finger motifs, a coiled-coil (leucine zipper) motif, and a homologous region in the C terminus that defines the TRAF family, the TRAF domain. The TRAF domain is involved in self-association and receptor binding.human cDNA has a 557-amino acid open reading frame that exhibits 80% identity to mouse TRAF5 at the amino acid level. Northern blot analysis revealed that human TRAF5 mRNA is expressed in all visceral organs. Western blotting revealed that the human protein is abundantly expressed in a human follicular dendritic cell line, and to a lesser degree in several tumor cell lines.

Reference

"Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5)."
Gene 207:135-140(1998) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Human TNF receptor-associated factor 5 (TRAF5): cDNA cloning, expression and assignment of the TRAF5 gene to chromosome 1q32."
Genomics 42:26-32(1997) [PubMed] [Europe PMC] [Abstract]

"The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators."
Cell. Signal. 13:389-400(2001) [PubMed] [Europe PMC] [Abstract]

"Tumor necrosis factor receptor-associated factors (TRAFs)."
Oncogene 20:6482-6491(2001) [PubMed] [Europe PMC] [Abstract]

"Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1."
J. Biol. Chem. 272:14029-14032(1997) [PubMed] [Europe PMC] [Abstract]

"ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5."
J. Biol. Chem. 272:13471-13474(1997) [PubMed] [Europe PMC] [Abstract]

"Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2."
Proc. Natl. Acad. Sci. U.S.A. 94:9792-9796(1997) [PubMed] [Europe PMC] [Abstract]

"Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation."
J. Biol. Chem. 272:2042-2045(1997) [PubMed] [Europe PMC] [Abstract]

"ASK1 is essential for JNK/SAPK activation by TRAF2."
Mol. Cell 2:389-395(1998) [PubMed] [Europe PMC] [Abstract]

"CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization."
Biochemistry 37:11836-11845(1998) [PubMed] [Europe PMC] [Abstract]

"Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation."
J. Biol. Chem. 273:5808-5814(1998) [PubMed] [Europe PMC] [Abstract]

"RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase."
J. Biol. Chem. 273:16968-16975(1998) [PubMed] [Europe PMC] [Abstract]

"TAJ, a novel member of the tumor necrosis factor receptor family, activates the c-Jun N-terminal kinase pathway and mediates caspase-independent cell death."
J. Biol. Chem. 275:15336-15342(2000) [PubMed] [Europe PMC] [Abstract]

"The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor."
J. Biol. Chem. 273:28355-28359(1998) [PubMed] [Europe PMC] [Abstract]

"TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation."
J. Biol. Chem. 275:18586-18593(2000) [PubMed] [Europe PMC] [Abstract]

"TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis factor family member involved in B cell regulation."
J. Exp. Med. 192:137-143(2000) [PubMed] [Europe PMC] [Abstract]

"B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1."
Proc. Natl. Acad. Sci. U.S.A. 97:9156-9161(2000) [PubMed] [Europe PMC] [Abstract]

"TRAF family proteins link PKR with NF-kappa B activation."
Mol. Cell. Biol. 24:4502-4512(2004) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]