Transforming Growth Factor Beta 1 Induced Transcript 1 (TGFb1I1)

ARA55; HIC-5; HIC5; TSC-5; Androgen receptor coactivator 55 kDa protein; Androgen receptor-associated protein of 55 kDa; Hydrogen peroxide-inducible clone 5 protein

SPN	P704
HGNC	11767
MGI	102784
PubMed	21984848
RGD	620173
UniProt	O43294
Wiki	TGFB1I1

Like the mouse Hic5 protein, the deduced human protein contains 444 amino acids with 4 LIM domains. They share 97% sequence identity in the double zinc finger LIM domains and 84.3% in the N-terminal domains. Both show sequence homology with the paxillin protein. Hic5 and Pparg colocalized to the villus epithelium of mouse small intestine, and their expression during embryonic gut development correlated with the transition from endoderm to specialized epithelium. Overexpression of HIC5 in colon cancer cells enhanced PPARG-mediated induction of several gut epithelial differentiation and maturation markers. Overexpression of HIC5 during mouse preadipocyte differentiation inhibited adipogenesis while inducing inappropriate expression of several mRNAs characteristic of gut epithelium.

Reference

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"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
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"ERK8 down-regulates transactivation of the glucocorticoid receptor through Hic-5."
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"Serotonin-, protein kinase C-, and Hic-5-associated redistribution of the platelet serotonin transporter."
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"Hic-5/ARA55 a prostate stroma-specific AR coactivator."
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"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
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