Plastin 3 (PLS3)

T-PLASTIN

SPN	P370
HGNC	9091
MGI	104807
PubMed	24088043
RGD	621409
UniProt	P13797
Wiki	PLS3

Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). The C-terminal 570 amino acids of the T-plastin and L-plastin proteins are 83% identical. It contains a potential calcium-binding site near the N terminus.Alternate splicing results in multiple transcript variants.

Reference

"Molecular cloning and characterization of plastin, a human leukocyte protein expressed in transformed human fibroblasts."
Mol. Cell. Biol. 8:4659-4668(1988) [PubMed] [Europe PMC] [Abstract]

"Correction of the N-terminal sequences of the human plastin isoforms by using anchored polymerase chain reaction: identification of a potential calcium-binding domain."
Mol. Cell. Biol. 10:1818-1821(1990) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of the human X chromosome."
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Human plastin genes. Comparative gene structure, chromosome location, and differential expression in normal and neoplastic cells."
J. Biol. Chem. 268:2781-2792(1993) [PubMed] [Europe PMC] [Abstract]

"Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry."
Proteomics 7:868-874(2007) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"PLS3 mutations in X-linked osteoporosis with fractures."
N. Engl. J. Med. 369:1529-1536(2013) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"The structure of an actin-crosslinking domain from human fimbrin."
Nat. Struct. Biol. 4:708-712(1997) [PubMed] [Europe PMC] [Abstract]

"Solution structure of the fourth CH domain from human plastin 3 T-isoform."
Submitted (NOV-2004) to the PDB data bank

"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]