Galactose-3-O-Sulfotransferase 1 (GAL3ST1)

CST; Cerebroside Sulfotransferase; Galactosylceramide sulfotransferase; 3'-phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase

SPN	O677
HGNC	24240
MGI	1858277
PubMed	20231363
UniProt	Q99999
Wiki	GAL3ST1

Sulfonation, an important step in the metabolism of many drugs, xenobiotics, hormones, and neurotransmitters, is catalyzed by sulfotransferases. GAL3ST1 is galactosylceramide sulfotransferase which catalyzes the conversion between 3'-phosphoadenylylsulfate + a galactosylceramide to adenosine 3',5'-bisphosphate + galactosylceramide sulfate. Activity of this sulfotransferase is enhanced in renal cell carcinoma.

The GalCer sulfotransferase cDNA encodes a 423-amino acid protein with a predicted type II transmembrane topology and 2 potential N-linked glycosylation sites. GalCer sulfotransferase is not homologous to either the cytosolic sulfotransferases or the Golgi sulfotransferases.

Reference

"Molecular cloning and expression of cDNA encoding human 3'-phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase."
J. Biol. Chem. 272:4864-4868(1997) [PubMed] [Europe PMC] [Abstract]

"Cancer-associated alternative usage of multiple promoters of human GalCer sulfotransferase gene."
Eur. J. Biochem. 267:2672-2679(2000) [PubMed] [Europe PMC] [Abstract]

"A genome annotation-driven approach to cloning the human ORFeome."
Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Purification and characterization of 3'-phosphoadenosine-5'-phosphosulfate:GalCer sulfotransferase from human renal cancer cells."
J. Biochem. 119:421-427(1996) [PubMed] [Europe PMC] [Abstract]