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Fc Fragment Of IgG Receptor Transporter Alpha (FcgRT)

FCRN; Neonatal Fc receptor; IgG receptor FcRn large subunit p51

The intestinal epithelium of neonatal mice and rats expresses an Fc receptor (FcRn) that mediates the selective uptake of immunoglobulin G (IgG) in mothers' milk, thereby helping newborn animals to acquire passive immunity. FcRn is structurally similar to the major histocompatibility complex class I molecule, which presents antigenic peptides to T cells. Like the MHC class I molecule, FcRn is made up of a heavy chain (approximately 48 kD) and beta-2-microglobulin. Its heavy chain shows approximately 35% amino acid sequence identity to that of a typical MHC class I molecule. Furthermore, the genomic organizations of the MHC class I and mouse FcRn heavy chain genes are similar in that the signal peptide, the 3 extracellular domains, the transmembrane region, and the cytoplasmic region are all encoded by separate exons.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPO639Hu01 Recombinant Fc Fragment Of IgG Receptor Transporter Alpha (FcgRT) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAO639Hu01 Monoclonal Antibody to Fc Fragment Of IgG Receptor Transporter Alpha (FcgRT) WB; IHC; ICC; IP.
PAO639Hu01 Polyclonal Antibody to Fc Fragment Of IgG Receptor Transporter Alpha (FcgRT) WB; IHC; ICC; IF.
Assay Kits CLO639Hu01 CLIA Kit for Fc Fragment Of IgG Receptor Transporter Alpha (FcgRT) CLIA assay for Antigen Detection
ELO639Hu01 ELISA Kit for Fc Fragment Of IgG Receptor Transporter Alpha (FcgRT) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPO639Mu01 Recombinant Fc Fragment Of IgG Receptor Transporter Alpha (FcgRT) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAO639Mu01 Monoclonal Antibody to Fc Fragment Of IgG Receptor Transporter Alpha (FcgRT) WB; IHC; ICC; IP.
PAO639Mu01 Polyclonal Antibody to Fc Fragment Of IgG Receptor Transporter Alpha (FcgRT) WB; IHC; ICC; IF.
Assay Kits CLO639Mu01 CLIA Kit for Fc Fragment Of IgG Receptor Transporter Alpha (FcgRT) CLIA assay for Antigen Detection
ELO639Mu01 ELISA Kit for Fc Fragment Of IgG Receptor Transporter Alpha (FcgRT) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPO639Ra01 Recombinant Fc Fragment Of IgG Receptor Transporter Alpha (FcgRT) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAO639Ra01 Monoclonal Antibody to Fc Fragment Of IgG Receptor Transporter Alpha (FcgRT) WB; IHC; ICC; IP.
PAO639Ra01 Polyclonal Antibody to Fc Fragment Of IgG Receptor Transporter Alpha (FcgRT) WB; IHC; ICC; IF.
Assay Kits CLO639Ra01 CLIA Kit for Fc Fragment Of IgG Receptor Transporter Alpha (FcgRT) CLIA assay for Antigen Detection
ELO639Ra01 ELISA Kit for Fc Fragment Of IgG Receptor Transporter Alpha (FcgRT) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPO639Ca01 Recombinant Fc Fragment Of IgG Receptor Transporter Alpha (FcgRT) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAO639Ca01 Monoclonal Antibody to Fc Fragment Of IgG Receptor Transporter Alpha (FcgRT) WB; IHC; ICC; IP.
PAO639Ca01 Polyclonal Antibody to Fc Fragment Of IgG Receptor Transporter Alpha (FcgRT) WB; IHC; ICC; IF.
Assay Kits CLO639Ca01 CLIA Kit for Fc Fragment Of IgG Receptor Transporter Alpha (FcgRT) CLIA assay for Antigen Detection
ELO639Ca01 ELISA Kit for Fc Fragment Of IgG Receptor Transporter Alpha (FcgRT) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPO639Po01 Recombinant Fc Fragment Of IgG Receptor Transporter Alpha (FcgRT) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAO639Po01 Monoclonal Antibody to Fc Fragment Of IgG Receptor Transporter Alpha (FcgRT) WB; IHC; ICC; IP.
PAO639Po01 Polyclonal Antibody to Fc Fragment Of IgG Receptor Transporter Alpha (FcgRT) WB; IHC; ICC; IF.
Assay Kits CLO639Po01 CLIA Kit for Fc Fragment Of IgG Receptor Transporter Alpha (FcgRT) CLIA assay for Antigen Detection
ELO639Po01 ELISA Kit for Fc Fragment Of IgG Receptor Transporter Alpha (FcgRT) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPO639Bo01 Recombinant Fc Fragment Of IgG Receptor Transporter Alpha (FcgRT) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAO639Bo01 Monoclonal Antibody to Fc Fragment Of IgG Receptor Transporter Alpha (FcgRT) WB; IHC; ICC; IP.
PAO639Bo01 Polyclonal Antibody to Fc Fragment Of IgG Receptor Transporter Alpha (FcgRT) WB; IHC; ICC; IF.
Assay Kits CLO639Bo01 CLIA Kit for Fc Fragment Of IgG Receptor Transporter Alpha (FcgRT) CLIA assay for Antigen Detection
ELO639Bo01 ELISA Kit for Fc Fragment Of IgG Receptor Transporter Alpha (FcgRT) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPO639Rb01 Recombinant Fc Fragment Of IgG Receptor Transporter Alpha (FcgRT) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAO639Rb01 Monoclonal Antibody to Fc Fragment Of IgG Receptor Transporter Alpha (FcgRT) WB; IHC; ICC; IP.
PAO639Rb01 Polyclonal Antibody to Fc Fragment Of IgG Receptor Transporter Alpha (FcgRT) WB; IHC; ICC; IF.
Assay Kits CLO639Rb01 CLIA Kit for Fc Fragment Of IgG Receptor Transporter Alpha (FcgRT) CLIA assay for Antigen Detection
ELO639Rb01 ELISA Kit for Fc Fragment Of IgG Receptor Transporter Alpha (FcgRT) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPO639Mo01 Recombinant Fc Fragment Of IgG Receptor Transporter Alpha (FcgRT) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAO639Mo01 Monoclonal Antibody to Fc Fragment Of IgG Receptor Transporter Alpha (FcgRT) WB; IHC; ICC; IP.
PAO639Mo01 Polyclonal Antibody to Fc Fragment Of IgG Receptor Transporter Alpha (FcgRT) WB; IHC; ICC; IF.
Assay Kits CLO639Mo01 CLIA Kit for Fc Fragment Of IgG Receptor Transporter Alpha (FcgRT) CLIA assay for Antigen Detection
ELO639Mo01 ELISA Kit for Fc Fragment Of IgG Receptor Transporter Alpha (FcgRT) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

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J. Exp. Med. 180:2377-2381(1994) [PubMed] [Europe PMC] [Abstract]

"Cloning and analysis of the gene encoding the human neonatal Fc receptor."
Eur. J. Immunogenet. 27:231-240(2000) [PubMed] [Europe PMC] [Abstract]

"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Crystal structure and immunoglobulin G binding properties of the human major histocompatibility complex-related Fc receptor."
Biochemistry 39:9698-9708(2000) [PubMed] [Europe PMC] [Abstract]