Coxsackie Virus And Adenovirus Receptor (CXADR)

CAR; HCAR; HCVADR; CVB3-binding protein; Coxsackievirus B-adenovirus receptor

SPN	O441
HGNC	2559
MGI	1201679
PubMed	22914544
RGD	619794
UniProt	P78310
Wiki	CXADR

CXADR is a type I membrane receptor for group B coxsackieviruses and subgroup C adenoviruses. Pseudogenes of this gene are found on chromosomes 15, 18, and 21. The deduced 365-amino acid human peptide has a calculated molecular mass of 39 kD and shares 83% sequence identity with the mouse homolog. Both peptides contain a potential leader sequence, transmembrane domains, 2 N-linked glycosylation sites, and 2 extracellular disulfide-bonded loops resembling the characteristic V and C2 domains of the immunoglobulins.transfection of CXADR or Cxadr into NIH 3T3 cells conferred susceptibility to infection by CVB3 and CVB4, resulting in 100- to 1000-fold higher virus titers following exposure than that found in nontransfected control cultures.

Reference

"HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses."
Proc. Natl. Acad. Sci. U.S.A. 94:3352-3356(1997) [PubMed] [Europe PMC] [Abstract]

"Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5."
Science 275:1320-1323(1997) [PubMed] [Europe PMC] [Abstract]

"Genomic organization and chromosomal localization of the human Coxsackievirus B-adenovirus receptor gene."
Hum. Genet. 105:354-359(1999) [PubMed] [Europe PMC] [Abstract]

"Interaction of coxsackievirus B3 with the full length coxsackievirus-adenovirus receptor."
Nat. Struct. Biol. 8:874-878(2001) [PubMed] [Europe PMC] [Abstract]

"Alternatively spliced soluble coxsackie-adenovirus receptors inhibit coxsackievirus infection."
J. Biol. Chem. 279:18497-18503(2004) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of human chromosome 21."
Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Expression of Coxsackie-adenovirus-receptor and alpha v-integrin does not correlate with adenovector targeting in vivo indicating anatomical vector barriers."
Gene Ther. 6:1520-1535(1999) [PubMed] [Europe PMC] [Abstract]

"The coxsackievirus-adenovirus receptor protein can function as a cellular attachment protein for adenovirus serotypes from subgroups A, C, D, E, and F."
J. Virol. 72:7909-7915(1998) [PubMed] [Europe PMC] [Abstract]

"Expression of the adenovirus receptor and its interaction with the fiber knob."
Exp. Cell Res. 255:47-55(2000) [PubMed] [Europe PMC] [Abstract]

"The coxsackie-adenovirus receptor (CAR) is used by reference strains and clinical isolates representing all six serotypes of coxsackievirus group B and by swine vesicular disease virus."
Virology 271:99-108(2000) [PubMed] [Europe PMC] [Abstract]

"Identification of alternative splice products encoded by the human coxsackie-adenovirus receptor gene."
Biochem. Biophys. Res. Commun. 287:216-222(2001) [PubMed] [Europe PMC] [Abstract]

"Human coxsackie-adenovirus receptor is colocalized with integrins alpha(v)beta(3) and alpha(v)beta(5) on the cardiomyocyte sarcolemma and upregulated in dilated cardiomyopathy: implications for cardiotropic viral infections."
Circulation 104:275-280(2001) [PubMed] [Europe PMC] [Abstract]

"Multiple regions within the coxsackievirus and adenovirus receptor cytoplasmic domain are required for basolateral sorting."
J. Biol. Chem. 276:25392-25398(2001) [PubMed] [Europe PMC] [Abstract]

"The coxsackievirus and adenovirus receptor is a transmembrane component of the tight junction."
Proc. Natl. Acad. Sci. U.S.A. 98:15191-15196(2001) [PubMed] [Europe PMC] [Abstract]

"Adenovirus fiber disrupts CAR-mediated intercellular adhesion allowing virus escape."
Cell 110:789-799(2002) [PubMed] [Europe PMC] [Abstract]

"Fatty acid modification of the coxsackievirus and adenovirus receptor."
J. Virol. 76:6382-6386(2002) [PubMed] [Europe PMC] [Abstract]

"The Coxsackievirus and adenovirus receptor (CAR) forms a complex with the PDZ domain-containing protein ligand-of-numb protein-X (LNX)."
J. Biol. Chem. 278:7439-7444(2003) [PubMed] [Europe PMC] [Abstract]

"Isoform-specific expression of the Coxsackie and adenovirus receptor (CAR) in neuromuscular junction and cardiac intercalated discs."
BMC Cell Biol. 5:42-42(2004) [PubMed] [Europe PMC] [Abstract]

"The coxsackievirus and adenovirus receptor interacts with the multi-PDZ domain protein-1 (MUPP-1) within the tight junction."
J. Biol. Chem. 279:48079-48084(2004) [PubMed] [Europe PMC] [Abstract]

"A role for the PDZ-binding domain of the coxsackie B virus and adenovirus receptor (CAR) in cell adhesion and growth."
J. Cell Sci. 117:4401-4409(2004) [PubMed] [Europe PMC] [Abstract]

"Neutrophil migration across tight junctions is mediated by adhesive interactions between epithelial CAR and a JAM-like protein on neutrophils."
Mol. Biol. Cell 16:2694-2703(2005) [PubMed] [Europe PMC] [Abstract]

"JAM-L-mediated leukocyte adhesion to endothelial cells is regulated in cis by alpha4beta1 integrin activation."
J. Cell Biol. 183:1159-1173(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Structural analysis of the mechanism of adenovirus binding to its human cellular receptor, CAR."
Science 286:1579-1583(1999) [PubMed] [Europe PMC] [Abstract]

"Dimeric structure of the coxsackievirus and adenovirus receptor D1 domain at 1.7 A resolution."
Structure 8:1147-1155(2000) [PubMed] [Europe PMC] [Abstract]

"Solution structure of the coxsackievirus and adenovirus receptor domain 1."
Biochemistry 43:1847-1853(2004) [PubMed] [Europe PMC] [Abstract]