A Disintegrin And Metalloprotease 15 (ADAM15)

MDC15; Metargidin; Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15; Metalloprotease RGD disintegrin protein

SPN	N965
HGNC	193
MGI	1333882
PubMed	11741929
RGD	620402
UniProt	Q13444
Wiki	ADAM15

The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. ADAM15 contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as an EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed.

Reference

"Metargidin, a membrane-anchored metalloprotease-disintegrin protein with an RGD integrin binding sequence."
J. Biol. Chem. 271:4593-4596(1996) [PubMed] [Europe PMC] [Abstract]

"Expression of a disintegrin-like protein in cultured human vascular cells and in vivo."
FASEB J. 11:173-180(1997) [PubMed] [Europe PMC] [Abstract]

"ADAM-15 inhibits wound healing in human intestinal epithelial cell monolayers."
Am. J. Physiol. 288:G346-G353(2005) [PubMed] [Europe PMC] [Abstract]

"ADAM15 gene structure and differential alternative exon use in human tissues."
BMC Mol. Biol. 8:90-90(2007) [PubMed] [Europe PMC] [Abstract]

"Distinct functions of natural ADAM-15 cytoplasmic domain variants in human mammary carcinoma."
Mol. Cancer Res. 6:383-394(2008) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Expression of members of a novel membrane linked metalloproteinase family (ADAM) in human articular chondrocytes."
Biochem. Biophys. Res. Commun. 230:335-339(1997) [PubMed] [Europe PMC] [Abstract]

"Specific interaction of the recombinant disintegrin-like domain of MDC-15 (metargidin, ADAM-15) with integrin alphavbeta3."
J. Biol. Chem. 273:7345-7350(1998) [PubMed] [Europe PMC] [Abstract]

"Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1."
J. Biol. Chem. 274:31693-31699(1999) [PubMed] [Europe PMC] [Abstract]

"Interaction of metargidin (ADAM-15) with alphavbeta3 and alpha5beta1 integrins on different haemopoietic cells."
J. Cell Sci. 112:579-587(1999) [PubMed] [Europe PMC] [Abstract]

"ADAM15 is an adherens junction molecule whose surface expression can be driven by VE-cadherin."
Exp. Cell Res. 279:239-247(2002) [PubMed] [Europe PMC] [Abstract]

"Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases."
J. Biol. Chem. 277:4999-5007(2002) [PubMed] [Europe PMC] [Abstract]

"The role of ADAM 15 in glomerular mesangial cell migration."
J. Biol. Chem. 277:33683-33689(2002) [PubMed] [Europe PMC] [Abstract]

"The adaptor protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells."
J. Biol. Chem. 278:16844-16851(2003) [PubMed] [Europe PMC] [Abstract]

"Homeostatic effects of the metalloproteinase disintegrin ADAM15 in degenerative cartilage remodeling."
Arthritis Rheum. 52:1100-1109(2005) [PubMed] [Europe PMC] [Abstract]

"Inhibition of airway smooth muscle adhesion and migration by the disintegrin domain of ADAM-15."
Am. J. Respir. Cell Mol. Biol. 37:494-500(2007) [PubMed] [Europe PMC] [Abstract]

"ADAM-15/metargidin mediates homotypic aggregation of human T lymphocytes and heterotypic interactions of T lymphocytes with intestinal epithelial cells."
J. Biol. Chem. 282:16948-16958(2007) [PubMed] [Europe PMC] [Abstract]

"ADAM15 suppresses cell motility by driving integrin alpha5beta1 cell surface expression via Erk inactivation."
Int. J. Biochem. Cell Biol. 40:2164-2173(2008) [PubMed] [Europe PMC] [Abstract]

"The ectodomain shedding of E-cadherin by ADAM15 supports ErbB receptor activation."
J. Biol. Chem. 283:18393-18401(2008) [PubMed] [Europe PMC] [Abstract]

"Characterization of the catalytic activity of the membrane-anchored metalloproteinase ADAM15 in cell-based assays."
Biochem. J. 420:105-113(2009) [PubMed] [Europe PMC] [Abstract]

"Alternative splicing of ADAM15 regulates its interactions with cellular SH3 proteins."
J. Cell. Biochem. 108:877-885(2009) [PubMed] [Europe PMC] [Abstract]