Non Metastatic Cells 2, Protein NM23B Expressed In (NME2)

NDPKB; NM23-H2; NM23B; Puf; Nucleoside diphosphate kinase B; C-myc purine-binding transcription factor PUF; Histidine protein kinase NDKB

SPN	N949
HGNC	7850
MGI	97356
PubMed	22251158
RGD	619877
UniProt	P22392
Wiki	NME2

The nm23-H1 gene also shares a significant homology with nucleoside diphosphate kinases and the Drosophila developmental gene awd. Northern blot hybridization indicated that the expression of the nm23-H1 gene is reduced to a lesser extent in tumor cells of high metastatic potential than is nm23-H1. Both proteins are independently active nucleoside diphosphate kinases and readily form intra- and intermolecular disulfide bonds.

NME2 is identical to the beta subunit of human erythrocyte NDP kinase. NDP kinases are involved in the synthesis of nucleoside triphosphates, and the NM23 protein may act in the regulation of signal transduction by complexing with G proteins, causing activation/inactivation of developmental pathways.

Reference

"Identification of a second human nm23 gene, nm23-H2."
Cancer Res. 51:445-449(1991) [PubMed] [Europe PMC] [Abstract]

"Nucleoside diphosphate kinase from human erythrocytes. Structural characterization of the two polypeptide chains responsible for heterogeneity of the hexameric enzyme."
J. Biol. Chem. 266:8784-8789(1991) [PubMed] [Europe PMC] [Abstract]

"Human c-myc transcription factor PuF identified as nm23-H2 nucleoside diphosphate kinase, a candidate suppressor of tumor metastasis."
Science 261:478-480(1993) [PubMed] [Europe PMC] [Abstract]

"Read-through transcript from NM23-H1 into the neighboring NM23-H2 gene encodes a novel protein, NM23-LV."
Genomics 87:483-489(2006) [PubMed] [Europe PMC] [Abstract]

"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Characterization of the human nm23-H2 promoter region and localization of the microsatellite D17S396."
Biochem. Biophys. Res. Commun. 215:910-914(1995) [PubMed] [Europe PMC] [Abstract]

"Integrin cytoplasmic domain-associated protein 1alpha (ICAP-1alpha) interacts directly with the metastasis suppressor nm23-H2, and both proteins are targeted to newly formed cell adhesion sites upon integrin engagement."
J. Biol. Chem. 277:20895-20902(2002) [PubMed] [Europe PMC] [Abstract]

"Lbc proto-oncogene product binds to and could be negatively regulated by metastasis suppressor nm23-H2."
Biochem. Biophys. Res. Commun. 320:1063-1068(2004) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

"Reversible histidine phosphorylation in mammalian cells: a teeter-totter formed by nucleoside diphosphate kinase and protein histidine phosphatase 1."
Methods Enzymol. 471:379-402(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Resveratrol-induced changes of the human adipocyte secretion profile."
J. Proteome Res. 11:4733-4743(2012) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"The crystal structure of a human nucleoside diphosphate kinase, NM23-H2."
J. Mol. Biol. 251:574-587(1995) [PubMed] [Europe PMC] [Abstract]

"X-ray structure of human nucleoside diphosphate kinase B complexed with GDP at 2-A resolution."
Structure 3:1307-1314(1995) [PubMed] [Europe PMC] [Abstract]