Phosphoinositide-3-Kinase Class-2-Beta Polypeptide (PIK3C2b)
C2-PI3K; PI3K-C2beta; Phosphoinositide 3-kinase-C2-beta
PIK3C2b belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN939Hu01 | Recombinant Phosphoinositide-3-Kinase Class-2-Beta Polypeptide (PIK3C2b) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN939Hu01 | Monoclonal Antibody to Phosphoinositide-3-Kinase Class-2-Beta Polypeptide (PIK3C2b) | WB; IHC; ICC; IP. |
| PAN939Hu01 | Polyclonal Antibody to Phosphoinositide-3-Kinase Class-2-Beta Polypeptide (PIK3C2b) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN939Hu01 | CLIA Kit for Phosphoinositide-3-Kinase Class-2-Beta Polypeptide (PIK3C2b) | CLIA assay for Antigen Detection |
| ELN939Hu01 | ELISA Kit for Phosphoinositide-3-Kinase Class-2-Beta Polypeptide (PIK3C2b) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN939Mu01 | Recombinant Phosphoinositide-3-Kinase Class-2-Beta Polypeptide (PIK3C2b) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN939Mu01 | Monoclonal Antibody to Phosphoinositide-3-Kinase Class-2-Beta Polypeptide (PIK3C2b) | WB; IHC; ICC; IP. |
| PAN939Mu01 | Polyclonal Antibody to Phosphoinositide-3-Kinase Class-2-Beta Polypeptide (PIK3C2b) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN939Mu01 | CLIA Kit for Phosphoinositide-3-Kinase Class-2-Beta Polypeptide (PIK3C2b) | CLIA assay for Antigen Detection |
| ELN939Mu01 | ELISA Kit for Phosphoinositide-3-Kinase Class-2-Beta Polypeptide (PIK3C2b) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN939Ra01 | Recombinant Phosphoinositide-3-Kinase Class-2-Beta Polypeptide (PIK3C2b) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN939Ra01 | Monoclonal Antibody to Phosphoinositide-3-Kinase Class-2-Beta Polypeptide (PIK3C2b) | WB; IHC; ICC; IP. |
| PAN939Ra01 | Polyclonal Antibody to Phosphoinositide-3-Kinase Class-2-Beta Polypeptide (PIK3C2b) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN939Ra01 | CLIA Kit for Phosphoinositide-3-Kinase Class-2-Beta Polypeptide (PIK3C2b) | CLIA assay for Antigen Detection |
| ELN939Ra01 | ELISA Kit for Phosphoinositide-3-Kinase Class-2-Beta Polypeptide (PIK3C2b) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN939Ca01 | Recombinant Phosphoinositide-3-Kinase Class-2-Beta Polypeptide (PIK3C2b) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN939Ca01 | Monoclonal Antibody to Phosphoinositide-3-Kinase Class-2-Beta Polypeptide (PIK3C2b) | WB; IHC; ICC; IP. |
| PAN939Ca01 | Polyclonal Antibody to Phosphoinositide-3-Kinase Class-2-Beta Polypeptide (PIK3C2b) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN939Ca01 | CLIA Kit for Phosphoinositide-3-Kinase Class-2-Beta Polypeptide (PIK3C2b) | CLIA assay for Antigen Detection |
| ELN939Ca01 | ELISA Kit for Phosphoinositide-3-Kinase Class-2-Beta Polypeptide (PIK3C2b) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN939Po01 | Recombinant Phosphoinositide-3-Kinase Class-2-Beta Polypeptide (PIK3C2b) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN939Po01 | Monoclonal Antibody to Phosphoinositide-3-Kinase Class-2-Beta Polypeptide (PIK3C2b) | WB; IHC; ICC; IP. |
| PAN939Po01 | Polyclonal Antibody to Phosphoinositide-3-Kinase Class-2-Beta Polypeptide (PIK3C2b) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN939Po01 | CLIA Kit for Phosphoinositide-3-Kinase Class-2-Beta Polypeptide (PIK3C2b) | CLIA assay for Antigen Detection |
| ELN939Po01 | ELISA Kit for Phosphoinositide-3-Kinase Class-2-Beta Polypeptide (PIK3C2b) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN939Bo01 | Recombinant Phosphoinositide-3-Kinase Class-2-Beta Polypeptide (PIK3C2b) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN939Bo01 | Monoclonal Antibody to Phosphoinositide-3-Kinase Class-2-Beta Polypeptide (PIK3C2b) | WB; IHC; ICC; IP. |
| PAN939Bo01 | Polyclonal Antibody to Phosphoinositide-3-Kinase Class-2-Beta Polypeptide (PIK3C2b) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN939Bo01 | CLIA Kit for Phosphoinositide-3-Kinase Class-2-Beta Polypeptide (PIK3C2b) | CLIA assay for Antigen Detection |
| ELN939Bo01 | ELISA Kit for Phosphoinositide-3-Kinase Class-2-Beta Polypeptide (PIK3C2b) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN939Rb01 | Recombinant Phosphoinositide-3-Kinase Class-2-Beta Polypeptide (PIK3C2b) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN939Rb01 | Monoclonal Antibody to Phosphoinositide-3-Kinase Class-2-Beta Polypeptide (PIK3C2b) | WB; IHC; ICC; IP. |
| PAN939Rb01 | Polyclonal Antibody to Phosphoinositide-3-Kinase Class-2-Beta Polypeptide (PIK3C2b) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN939Rb01 | CLIA Kit for Phosphoinositide-3-Kinase Class-2-Beta Polypeptide (PIK3C2b) | CLIA assay for Antigen Detection |
| ELN939Rb01 | ELISA Kit for Phosphoinositide-3-Kinase Class-2-Beta Polypeptide (PIK3C2b) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN939Mo01 | Recombinant Phosphoinositide-3-Kinase Class-2-Beta Polypeptide (PIK3C2b) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN939Mo01 | Monoclonal Antibody to Phosphoinositide-3-Kinase Class-2-Beta Polypeptide (PIK3C2b) | WB; IHC; ICC; IP. |
| PAN939Mo01 | Polyclonal Antibody to Phosphoinositide-3-Kinase Class-2-Beta Polypeptide (PIK3C2b) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN939Mo01 | CLIA Kit for Phosphoinositide-3-Kinase Class-2-Beta Polypeptide (PIK3C2b) | CLIA assay for Antigen Detection |
| ELN939Mo01 | ELISA Kit for Phosphoinositide-3-Kinase Class-2-Beta Polypeptide (PIK3C2b) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Identification and cDNA cloning of a novel mammalian C2 domain-containing phosphoinositide 3-kinase, HsC2-PI3K."
Biochem. Biophys. Res. Commun. 233:537-544(1997) [PubMed] [Europe PMC] [Abstract]
"Human phosphoinositide 3-kinase C2beta, the role of calcium and the C2 domain in enzyme activity."
J. Biol. Chem. 273:33082-33090(1998) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
"Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors."
Mol. Cell. Biol. 20:3817-3830(2000) [PubMed] [Europe PMC] [Abstract]
"Recruitment of the class II phosphoinositide 3-kinase C2beta to the epidermal growth factor receptor: role of Grb2."
Mol. Cell. Biol. 21:6660-6667(2001) [PubMed] [Europe PMC] [Abstract]
"Topographical expression of class IA and class II phosphoinositide 3-kinase enzymes in normal human tissues is consistent with a role in differentiation."
BMC Clin. Pathol. 3:4-4(2003) [PubMed] [Europe PMC] [Abstract]
"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]