Numb Homolog (NUMB)

Protein S171

SPN	N828
HGNC	8060
MGI	107423
PubMed	20940030
RGD	620107
UniProt	P49757
Wiki	NUMB

contains a predicted phosphotyrosine-binding domain and shares 63% identity with Drosophila Numb. The C-terminal half shows little similarity with Drosophila Numb and includes a proline-rich segment with potential SH3-binding sites. Immunofluorescence experiments revealed that mouse Numb is asymmetrically localized to the apical membrane of dividing ventricular neural progenitors during mouse cortical neurogenesis. However, unlike Drosophila Numb, there was no correlation between cleavage planes and mouse Numb localization at the apical cell membrane in anaphase ventricular cells.NUMB contains an N-terminal phosphotyrosine-binding (PTB) domain, SH3-binding sites, and a C-terminal asn-pro-phe (NPF) motif. NUMB shares 57% amino acid identity with NUMBL.

Reference

"Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module."
Genes Dev. 11:2239-2249(1997) [PubMed] [Europe PMC] [Abstract]

"Distinct human NUMB isoforms regulate differentiation vs. proliferation in the neuronal lineage."
Proc. Natl. Acad. Sci. U.S.A. 96:10472-10476(1999) [PubMed] [Europe PMC] [Abstract]

"Characterization and role of NUMB in the human extravillous trophopblast."
Placenta 32:441-449(2011) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and analysis of human chromosome 14."
Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease."
Nature 375:754-760(1995) [PubMed] [Europe PMC] [Abstract]

"Siah-1 binds and regulates the function of Numb."
Proc. Natl. Acad. Sci. U.S.A. 98:15067-15072(2001) [PubMed] [Europe PMC] [Abstract]

"RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis."
J. Biol. Chem. 278:30597-30604(2003) [PubMed] [Europe PMC] [Abstract]

"A novel transmembrane protein recruits numb to the plasma membrane during asymmetric cell division."
J. Biol. Chem. 279:11304-11312(2004) [PubMed] [Europe PMC] [Abstract]

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]