Dishevelled, Dsh Homolog 1 (DVL1)
DSH homolog 1; Segment polarity protein dishevelled homolog DVL-1
DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification.
DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development. Three transcript variants encoding three different isoforms have been found for this gene.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN684Hu01 | Recombinant Dishevelled, Dsh Homolog 1 (DVL1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN684Hu01 | Monoclonal Antibody to Dishevelled, Dsh Homolog 1 (DVL1) | WB; IHC; ICC; IP. |
| PAN684Hu01 | Polyclonal Antibody to Dishevelled, Dsh Homolog 1 (DVL1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN684Hu01 | CLIA Kit for Dishevelled, Dsh Homolog 1 (DVL1) | CLIA assay for Antigen Detection |
| ELN684Hu01 | ELISA Kit for Dishevelled, Dsh Homolog 1 (DVL1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN684Mu01 | Recombinant Dishevelled, Dsh Homolog 1 (DVL1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN684Mu01 | Monoclonal Antibody to Dishevelled, Dsh Homolog 1 (DVL1) | WB; IHC; ICC; IP. |
| PAN684Mu01 | Polyclonal Antibody to Dishevelled, Dsh Homolog 1 (DVL1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN684Mu01 | CLIA Kit for Dishevelled, Dsh Homolog 1 (DVL1) | CLIA assay for Antigen Detection |
| ELN684Mu01 | ELISA Kit for Dishevelled, Dsh Homolog 1 (DVL1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN684Ra01 | Recombinant Dishevelled, Dsh Homolog 1 (DVL1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN684Ra01 | Monoclonal Antibody to Dishevelled, Dsh Homolog 1 (DVL1) | WB; IHC; ICC; IP. |
| PAN684Ra01 | Polyclonal Antibody to Dishevelled, Dsh Homolog 1 (DVL1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN684Ra01 | CLIA Kit for Dishevelled, Dsh Homolog 1 (DVL1) | CLIA assay for Antigen Detection |
| ELN684Ra01 | ELISA Kit for Dishevelled, Dsh Homolog 1 (DVL1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN684Ca01 | Recombinant Dishevelled, Dsh Homolog 1 (DVL1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN684Ca01 | Monoclonal Antibody to Dishevelled, Dsh Homolog 1 (DVL1) | WB; IHC; ICC; IP. |
| PAN684Ca01 | Polyclonal Antibody to Dishevelled, Dsh Homolog 1 (DVL1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN684Ca01 | CLIA Kit for Dishevelled, Dsh Homolog 1 (DVL1) | CLIA assay for Antigen Detection |
| ELN684Ca01 | ELISA Kit for Dishevelled, Dsh Homolog 1 (DVL1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN684Po01 | Recombinant Dishevelled, Dsh Homolog 1 (DVL1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN684Po01 | Monoclonal Antibody to Dishevelled, Dsh Homolog 1 (DVL1) | WB; IHC; ICC; IP. |
| PAN684Po01 | Polyclonal Antibody to Dishevelled, Dsh Homolog 1 (DVL1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN684Po01 | CLIA Kit for Dishevelled, Dsh Homolog 1 (DVL1) | CLIA assay for Antigen Detection |
| ELN684Po01 | ELISA Kit for Dishevelled, Dsh Homolog 1 (DVL1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN684Bo01 | Recombinant Dishevelled, Dsh Homolog 1 (DVL1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN684Bo01 | Monoclonal Antibody to Dishevelled, Dsh Homolog 1 (DVL1) | WB; IHC; ICC; IP. |
| PAN684Bo01 | Polyclonal Antibody to Dishevelled, Dsh Homolog 1 (DVL1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN684Bo01 | CLIA Kit for Dishevelled, Dsh Homolog 1 (DVL1) | CLIA assay for Antigen Detection |
| ELN684Bo01 | ELISA Kit for Dishevelled, Dsh Homolog 1 (DVL1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN684Rb01 | Recombinant Dishevelled, Dsh Homolog 1 (DVL1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN684Rb01 | Monoclonal Antibody to Dishevelled, Dsh Homolog 1 (DVL1) | WB; IHC; ICC; IP. |
| PAN684Rb01 | Polyclonal Antibody to Dishevelled, Dsh Homolog 1 (DVL1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN684Rb01 | CLIA Kit for Dishevelled, Dsh Homolog 1 (DVL1) | CLIA assay for Antigen Detection |
| ELN684Rb01 | ELISA Kit for Dishevelled, Dsh Homolog 1 (DVL1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN684Mo01 | Recombinant Dishevelled, Dsh Homolog 1 (DVL1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN684Mo01 | Monoclonal Antibody to Dishevelled, Dsh Homolog 1 (DVL1) | WB; IHC; ICC; IP. |
| PAN684Mo01 | Polyclonal Antibody to Dishevelled, Dsh Homolog 1 (DVL1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN684Mo01 | CLIA Kit for Dishevelled, Dsh Homolog 1 (DVL1) | CLIA assay for Antigen Detection |
| ELN684Mo01 | ELISA Kit for Dishevelled, Dsh Homolog 1 (DVL1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Human dishevelled genes constitute a DHR-containing multigene family."
Genomics 42:302-310(1997) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
"beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins."
Proc. Natl. Acad. Sci. U.S.A. 98:14889-14894(2001) [PubMed] [Europe PMC] [Abstract]
"Identification and characterization of a novel Dvl-binding protein that suppresses Wnt signalling pathway."
Genes Cells 8:1005-1017(2003) [PubMed] [Europe PMC] [Abstract]
"Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth."
Cell 119:97-108(2004) [PubMed] [Europe PMC] [Abstract]
"Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways."
Nat. Genet. 37:537-543(2005) [PubMed] [Europe PMC] [Abstract]
"Identification of transmembrane protein 88 (TMEM88) as a dishevelled-binding protein."
J. Biol. Chem. 285:41549-41556(2010) [PubMed] [Europe PMC] [Abstract]
"DCDC2 mutations cause a renal-hepatic ciliopathy by disrupting Wnt signaling."
Am. J. Hum. Genet. 96:81-92(2015) [PubMed] [Europe PMC] [Abstract]